Results 71 to 80 of about 1,755,884 (316)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
IEEE AccessThis paper introduces an innovative $4 \times 4$ dual-band Butler matrix (BM) characterized by compactness and an enhanced frequency ratio (K). The design employs meandered lines and an interdigital capacitor (IDC) unit-cell-based composite right/left ...
Abdulkadir Bello Shallah +6 more
doaj +1 more source
The use of frequency-separation ratios for asteroseismology [PDF]
Monthly Notices of the Royal Astronomical Society, 2005 The systematic patterns of separations between frequencies of modes of different degree and order are a characteristic of p-mode oscillations of stars. The frequency separations depend on the internal structure of the star and so measuring them in the observed oscillation spectra of variable stars gives valuable diagnostics of the interior of a star ...
Otí Floranes, H. +2 more
openaire +2 more sources
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
, 2001 The effect of time-domain and frequency-domain synchronization errors is quantified in the context of various coherently and noncoherently detected 1, 2, and 4 bits/symbol OFDM constellations, in order to demonstrate the wide applicability of the ...
Piazzo, L. +7 more
core +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
, 2010 Low-frequency torsional resonance arising from large inertia load and elastic shaft causes vibration when industrial servo system is working, which degrades the system's performance of motion control.
Xu F(徐方) +2 more
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