Results 81 to 90 of about 1,755,884 (316)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Frequency-domain model of optical frequency-comb generation in optical resonators with second- and third-order nonlinearities

open access: yes, 2020
We developed a frequency-domain model describing optical frequency-comb generation in optical resonators with second- and third-order nonlinearities. Compared with time-domain models, our model in principle allows one to express the cavity dispersion ...
Enxu Zhu (14406096)   +2 more
core   +1 more source

Comparing a mercury optical lattice clock with microwave and optical frequency standards

open access: yesNew Journal of Physics, 2016
In this paper we report the evaluation of an optical lattice clock based on neutral mercury with a relative uncertainty of $1.7\times {10}^{-16}$ . Comparing this characterized frequency standard to a ^133 Cs atomic fountain we determine the absolute ...
R Tyumenev   +11 more
doaj   +1 more source

Landslide Susceptibility Mapping Using Integrated Methods: A Case Study in the Chittagong Hilly Areas, Bangladesh

open access: yesGeosciences, 2020
Landslide susceptibility mapping is of critical importance to identify landslide-prone areas to reduce future landslides, causalities, and infrastructural damages.
Yasin Wahid Rabby, Yingkui Li
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Low-Complexity Erasure Insertion in Frequency-Hopping Spread-Spectrum Communications Subjected to Fading and Partial-Band Interference

open access: yes, 2001
In this paper we propose two novel low-complexity, low-delay erasure insertion schemes, namely the Output Threshold Test (OTT) and joint Maximum Output and Ratio Threshold Test (MO-RTT).
Yang, L-L., Hanzo, L.
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Low complexity Erasure Insertion in RS-Coded SFH Spread-Spectrum Communications with Partial-Band Interference and Nakagami-$m$ Fading

open access: yes, 2002
—In this paper we propose two novel low-complexity, low-delay erasure insertion schemes, namely, the output threshold test (OTT) and joint maximum output and ratio threshold Test (MO-RTT). The employment of the OTT and MO-RTT is beneficial in the context
Yang, Lie-Liang, Hanzo, Lajos
core  

Erasure Insertion in Reed-Solomon Coded SFH M-ary FSK with Partial-Band Interference and Rayleigh Fading for Non-Coherent Cooperative Communications [PDF]

open access: yes, 2011
The rationale of our design is that although much of the literature of cooperative systems assumes perfect coherent detection, the assumption of having any channel estimates at the relays imposes an unreasonable burden on the relay station.
Yang, Lie-Liang   +7 more
core   +1 more source

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