Results 101 to 110 of about 797,994 (268)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Predictive Frequency Regulation Control Strategy Based on Photovoltaic and Energy Storage in Islanded Microgrids

IET Renewable Power Generation
Aiming at the problems of frequency fluctuation caused by load changes and low utilisation rate of renewable energy during the operation of isolated microgrids, a flexible power allocation strategy based on model predictive control (MPC) in which ...
Chunhui Liang, Chenglong Huang, Renjie Liu, Xiaoyang Zuo, Jinfa Li   +4 more
doaj   +1 more source

Robust Frequency Regulation Management System in a Renewable Hybrid Energy Network with Integrated Storage Solutions

Electricity
The rapid proliferation of renewable energy sources (RESs) has significantly reduced system inertia, thereby intensifying stability challenges in modern power grids.
Subhranshu Sekhar Pati, Umamani Subudhi, Sivkumar Mishra   +2 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Optimized Non-Integer with Disturbance Observer Frequency Control for Resilient Modern Airport Microgrid Systems

Fractal and Fractional
Various sectors focus on transitioning to clean and renewable energy sources, particularly airport microgrids (AMGs), which offer the potential for highly reliable and resilient operations.
Amr A. Raslan, Mokhtar Aly, Emad A. Mohamed, Waleed Alhosaini, Emad M. Ahmed, Loai S. Nasrat, Sayed M. Said   +6 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Adaptive Frequency Control to Overcome Packet Dropouts and Uncertainties in Hybrid Power Systems

IEEE Access
The increasing integration of renewable energy into hybrid power systems (HPS) introduces significant uncertainties, posing challenges to frequency control.
Renuka Loka, Alivelu M. Parimi, Srinivasa Rao Gampa, Nallapaneni Manoj Kumar   +3 more
doaj   +1 more source