Results 101 to 110 of about 2,213,154 (301)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Review of primary frequency control requirements on the GB power system against a background of increasing renewable generation

, 2006
This thesis was submitted for the degree of Doctor of Engineering and awarded by Brunel University.The system frequency of a synchronous power system varies with the imbalance of energy supplied and the electrical energy consumed.
Pearmine, Ross
core  

Subcortical neural synchrony and absolute thresholds predict frequency discrimination independently [PDF]

, 2013
The neural mechanisms of pitch coding have been debated for more than a century. The two main mechanisms are coding based on the profiles of neural firing rates across auditory nerve fibers with different characteristic frequencies (place-rate coding ...
Marmel, F., Gockel, H. E., Plack, C. J., R. P. Carlyon, C. J. Plack, Hopkins, K., Plack, C. J.; id_orcid, F. Marmel, H. E. Gockel, Marmel, Frederic, Gockel, Hedwig, D. Linley, K. Hopkins, Linley, D., Carlyon, R. P.   +14 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Stabilization of grid frequency through dynamic demand control

, 2007
Frequency stability in electricity networks is essential to the maintenance of supply quality and security. This paper investigates whether a degree of built-in frequency stability could be provided by incorporating dynamic demand control into certain ...
Freris, Leon L., Infield, David G., Short, J.A., Freris, L.L., Infield, D.G., Short, Joe A.   +5 more
core   +1 more source

Frequency Response Analysis of the Unsteady-State CO/CO2 Methanation Reaction: An Experimental Study

, 2022
The utilization of renewable electricity for power-to-gas (PtG) applications induces fluctuations in the H2 availability from water electrolysis. For subsequent methanation of CO or CO2 the unsteady-state operation of the respective reactor allows to ...
Dominik, Meyer, Jannik, Schumacher, Robert, Güttel, Jens, Friedland   +3 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Repetition enhancement for frequency-modulated but not unmodulated sounds: a human MEG study

, 2010
Background: Decoding of frequency-modulated (FM) sounds is essential for phoneme identification. This study investigates selectivity to FM direction in the human auditory system.
Christian F. Altmann, Benjamin Rahm, Rahm Benjamin, Jochen Kaiser, Heinemann, Linda Verena, Bernhard H. Gaese, Christian F Altmann, Kaiser, Jochen, Gaese, Bernhard, Altmann Christian F., Linda V. Heinemann, Bernhard H Gaese, Kaiser Jochen, Rahm, Benjamin, Altmann, Christian F., Heinemann Linda V., Gaese Bernhard H., Linda V Heinemann   +17 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source