Results 131 to 140 of about 23,652 (302)

Inductive queries for a drug designing robot scientist

, 2010
It is increasingly clear that machine learning algorithms need to be integrated in an iterative scientific discovery loop, in which data is queried repeatedly by means of inductive queries and where the computer provides guidance to the experiments that ...
Amanda Schierz, Andrew Sparkes, Amanda Clare, Jan Ramon, King, Ross D., Nijssen, Siegfried, Rowland, Jem J., Rowland, Jem, Jem Rowland, Sparkes, Andrew, Ross D. King, Siegfried Nijssen, Schierz, Amanda C., Clare, Amanda, Schierz, Amanda, Ramon, Jan   +15 more
core   +1 more source

Phase Fraction Modulation Enhances Li+/Na+ Diffusion Disparity in Spent LiFePO4 Cathodes for Efficient Lithium Extraction from Brine

Advanced Science, EarlyView.
A direct cascaded utilization strategy for spent LiFePO4 batteries efficiently extracts lithium from brine, embodying the “urban mining” concept. Phase fraction modulation revealed its significant impact on local bond lengths of crystal structure and the Li/Na diffusion energy barrier, identifying the best material (Li0.19FePO4) for lithium extraction.
Ruiqi Yin, Qihan Huang, Jiayu Hao, Guosheng Li, Guoxing Ren, Dongfu Liu, Zhongwei Zhao, Wenhua Xu   +7 more
wiley   +1 more source

Mining Frequent Item Sets Data Streams using "ÉclatAlgorithm"

, 2014
Frequent pattern mining is the process of mining data in a set of items or some patterns from a largedatabase. The resulted frequent set data supports the minimum support threshold.
Richhariya, Pankaj; Computer Science Department BITS, Bhopal, India, Khambra, Geetanjli; Computer Science Department BITS, Bhopal, India   +1 more
core   +1 more source

Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants

Advanced Science, EarlyView.
A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei, Kai Zhang, Shuke Deng, Jinjie Chen, Xiaomei Huang, Jingfei Guo, Yuqing Wu, Yingjie Guo, Zhen Liang   +8 more
wiley   +1 more source

Detecting Trending Topics Using Soft Frequent Pattern Mining (SFPM) on Indonesian Language Tweets Related to Earthquake News

Jurnal Nasional Pendidikan Teknik Informatika (JANAPATI)
Social media users frequently post updates regarding ongoing natural disasters, including specific details and locations. These posts are crucial for real-time insights into such events; however, their informal tone and use of slang can make them ...
Indra Indra, M Syawaladi Kukuh Prakoso, Mekar Bunga Allamanda Rosul, Mufti Mufti   +3 more
doaj   +1 more source

Towards pattern-based service identification [PDF]

, 2008
Service-Oriented Architecture is a promising architectural approach to solve the integration problem originated by business process integration and automation requirements.
Claus Pahl (12588787), Pahl, Claus, Veronica Gacitua-Decar (12588796), Gacitua-Decar, Veronica   +3 more
core  

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Frequent Pattern Mining over Streaming Data: From models to research challenges [PDF]

IJCI International Journal of Computers and Information, 2021
A. Saad, Hatem Abdel-Kader, Rashed Salem
doaj   +1 more source