Results 41 to 50 of about 23,652 (302)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
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Frequent pattern mining with uncertain data [PDF]
Proceedings of the 15th ACM SIGKDD international conference on Knowledge discovery and data mining, 2009 This paper studies the problem of frequent pattern mining with uncertain data. We will show how broad classes of algorithms can be extended to the uncertain data setting. In particular, we will study candidate generate-and-test algorithms, hyper-structure algorithms and pattern growth based algorithms.
Charu C. Aggarwal +3 more
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
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Grasping frequent subgraph mining for bioinformatics applications
BioData Mining, 2018 Searching for interesting common subgraphs in graph data is a well-studied problem in data mining. Subgraph mining techniques focus on the discovery of patterns in graphs that exhibit a specific network structure that is deemed interesting within these ...
Aida Mrzic +6 more
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An Efficient Approach to Mining Maximal Contiguous Frequent Patterns from Large DNA Sequence Databases [PDF]
Genomics & Informatics, 2012 Mining interesting patterns from DNA sequences is one of the most challenging tasks in bioinformatics and computational biology. Maximal contiguous frequent patterns are preferable for expressing the function and structure of DNA sequences and hence can ...
Md. Rezaul Karim +3 more
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IEEE Access, 2021 One of the most challenging tasks in association rule mining is that when a new incremental database is added to an original database, some existing frequent itemsets may become infrequent itemsets and vice versa.
Wannasiri Thurachon, Worapoj Kreesuradej
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Fault Tolerant Frequent Pattern Mining [PDF]
2016 IEEE 23rd International Conference on High Performance Computing (HiPC), 2016 FP-Growth algorithm is a Frequent Pattern Min- ing (FPM) algorithm that has been extensively used to study correlations and patterns in large scale datasets. While several researchers have designed distributed memory FP-Growth algorithms, it is pivotal to consider fault tolerant FP-Growth, which can address the increasing fault rates in large scale ...
Sameh Shohdy +2 more
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IEEE AccessTopic detection in social networks is extracting and summarizing frequent posts about an event or subject. Topic detection is a complex process and depends on language because it somehow needs to analyze text.
Elnaz Zafarani-Moattar +2 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source