Results 31 to 40 of about 7,917 (184)

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Leveraging Big Multitemporal Multisource Satellite Data and Artificial Intelligence for the Detection of Complex and Invisible Features: The Case of Extensive Irrigation Mapping

Archaeological Prospection, EarlyView.
ABSTRACT The detection of buried or obscured archaeological features remains a central challenge in landscape archaeology, particularly in the irrigated floodplains of Mesopotamia where levees and canals formed the basis of complex agrarian systems. This study presents a deep learning–based approach for the large‐scale, automated detection of ancient ...
Nazarij Buławka, Hector A. Orengo, Felipe Lumbreras Ruiz, Iban Berganzo‐Besga, Ekta Gupta   +4 more
wiley   +1 more source

Climate‐Resilient Agri‐Food Systems (CRAFS): A Review of Approaches and Outcomes of Agri‐Food Systems

Sustainable Development, EarlyView.
ABSTRACT Climate change is increasingly destabilizing agri‐food systems globally, with complex disruptions extending across production, distribution, and consumption. In response, climate‐resilient agri‐food system (CRAFS) approaches have gained prominence as a means to sustain food security under escalating climatic stressors.
M Manjurul Islam, Evan D. G. Fraser
wiley   +1 more source

A Platform for the Actuation of Magnetically Labeled Skeletal Muscle Cells Using Dynamic Magnetic Stimulation

Small, EarlyView.
A magnetic stimulation platform for the remote stimulation of cells is presented, consisting of a magnetic stimulator and magnetic microspheres. Skeletal muscle cells are labeled with magnetic microspheres, which act as local magnetic actuators on the cells upon application of the magnetic field.
Tayná C. Rodrigues, Anna‐Lena Bauknecht, Anna Gioran, Sabine Rosenfeldt, Daniel Dickes, Johann Schorzmann, Frank Döpper, Elisabetta A. Cavalcanti‐Adam, Michael Maier, Reinhard Richter, Marissa K. Caldow, Gordon S. Lynch, Daniel E. Heath, Andrea J. O'Connor, Sahar Salehi   +14 more
wiley   +1 more source

Greek ΜΝΗΣΘΗ and Aramaic DKYR in the Near East: A Comparative Epigraphic Study

Arabian Archaeology and Epigraphy, EarlyView.
ABSTRACT Past studies of graffiti containing the word ΜΝΗΣΘΗ have never fully established its intrinsic meaning. However, due to the existence of the Aramaic term DKYR, which carries a seemingly identical meaning to ΜΝΗΣΘΗ, in similar contexts in the Roman Near East, a comparison between both words is possible. Four distinct sites where the coexistence
Sebastien Mazurek
wiley   +1 more source

Do schema modes predict outcome of cognitive behavioural therapy in patients with obsessive–compulsive disorder and anxiety disorders?

British Journal of Clinical Psychology, EarlyView.
Abstract Objectives Cognitive behavioural therapy (CBT) is the psychological treatment of choice for patients with obsessive–compulsive disorder (OCD) or an anxiety disorder. However, a substantial group (30–40%) does not profit sufficiently. Predictors of outcome inform us about how to adapt interventions for this group.
Manon Peeters, Boris van Passel, Nancy Peeters, Julie Krans   +3 more
wiley   +1 more source

Shame as a mediator of the association of childhood emotional abuse with aversive cognitive perseveration in adults

British Journal of Psychology, EarlyView.
Abstract Childhood emotional abuse (CEA) has been linked to response‐focused emotion regulation in adulthood. However, the underlying mechanisms remain unexplored. This pre‐registered study examined whether shame mediates the association between CEA history and aversive cognitive perseveration (ACP), including brooding rumination, experiential ...
Mohammadali Amini‐Tehrani, Michael Weinborn, Kenneth Sim, Jeneva L. Ohan, Kristin Naragon‐Gainey   +4 more
wiley   +1 more source

Crisis epilépticas en niños con síndrome de Dravet en condiciones de calor extremo: estudio cualitativo de la perspectiva de los progenitores

Developmental Medicine &Child Neurology, EarlyView.
Resumen Objetivo Describir la experiencia de progenitores de niños y adolescentes con síndrome de Dravet en relación con el impacto de las olas de calor o las altas temperaturas ambientales en las crisis epilépticas de sus hijos, así como las estrategias de afrontamiento empleadas.
Angel Aledo‐Serrano, José Ángel Aibar, Domingo Palacios‐Ceña, Maria Salcedo‐Perez‐Juana, Maria Palacios‐Ceña, Simona Giorgi, Manuel Lorenzo‐Dieguez, Sanjay M Sisodiya, Cristina García‐Bravo   +8 more
wiley   +1 more source

Increasing Evidence for the Use of Sodium Oxybate in Multi-Drug-Resistant Lance–Adams Syndrome

Tremor and Other Hyperkinetic Movements, 2019
Background: Treatment of posthypoxic myoclonus (PHM) can be a challenge in patients not responsive to first-line medications. PMH is a rare condition that has a dramatic impact on patients’ quality of life. Refractory cases are not uncommon. Case report:
Giulietta M. Riboldi, Steven J. Frucht
doaj   +1 more source

The Place for Form in Wollheim's Lectures on Formalism and Pictorial Organization

European Journal of Philosophy, EarlyView.
Abstract At the time of his death, Richard Wollheim was writing a short book on Formalism and Pictorial Organization. Much of it, but by no means all of it, had been published before (it has come out posthumously in its entirety in late 2025). Here I do two things. First, I have provided a rather detailed exegesis concentrating on the parts of the book
Gary Kemp
wiley   +1 more source