Results 201 to 210 of about 1,105,287 (296)

Targeted‐Penetrating Biomimetic Hybrid Transfersomes for Enhanced Transdermal Gene Transfection in Hypertrophic Scar Therapy

Advanced Science, EarlyView.
Hypertrophic scar fibroblasts membrane‐hybridized cationic transfersomes enable efficient loading and transdermal delivery of TGF‐β1 siRNA through multiple skin penetration pathways. The biomimetic platform enhances homotypic targeting, transfection, and immune evasion, suppresses TGF‐β1‐driven fibrotic signaling, and reduces extracellular matrix ...
Hui Xing, Ziyi Zhao, Yuhui Yang, Yichen Lin, Yinglin Xuan, Ziyang Wang, Kai Lv, Xiaoxu Zhu, Zhi Zhang, Dong Ma   +9 more
wiley   +1 more source

Energy paradox in REM sleep: balancing supply and consumption in brain metabolism. [PDF]

Commun Biol
Takahashi Y, Ikoma Y, Matsui K.
europepmc   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

High-fidelity nanoflares: design strategies, response mechanisms, and biomedical applications. [PDF]

Chem Sci
Zhou Y, Xu A, Quan K, Lei Y, Zhang X, Liu J, Qing Z.   +6 more
europepmc   +1 more source

Robust, Breathable and Stretchable Liquid Metal Composite Nanofibre for Physiological Electrical Signal Monitoring

Advanced Science, EarlyView.
A conductive TPU/liquid‐metal nanofibrous film is fabricated via ultrasonic dispersion, electrospinning, and mold imprinting. The film is breathable, stretchable, deformation‐stable, and provides electromagnetic shielding. n‐Butanol encapsulation mitigates liquid‐metal surface tension and improves biocompatibility. Stable ECG, EOG, EEG, and EMG signals
Cong Huang, Zhenyu Chen, Zedong Jiang, Yuhao Jiang, Haohong Jiang, Zhenli Zhou, Yunlu Pan, Shu‐Jen Wang   +7 more
wiley   +1 more source

Distinct metabolic dependency on BCAA defines cancer stemness and malignancy in human triple-negative breast cancer. [PDF]

Cell Rep
Matsuura K, Shinonaga R, Yamamoto M, Yamamoto Y, Chen H, Maeno A, Okuda K, Inoue H, Imotani S, Glushka J, Miki K, Watanabe Y, Takada M, Kaji H, Inoue JI, Hattori A, Imamura H, Ito T.   +17 more
europepmc   +1 more source

Freestanding PZT Films for Integrated Wearable Sensing and Intelligent Acoustic Recognition

Advanced Science, EarlyView.
A freestanding epitaxial PZT/LaNiO3/Pt heterostructure is achieved via water‐assisted delamination from mica, effectively eliminating substrate‐induced clamping and releasing intrinsic ferroelectricity. The released film exhibits substantially enhanced remanent polarization and piezoelectric response, delivering excellent mechanical flexibility and ...
Hailong Pan, Zhichao Xu, Rongxiao Liu, Jianmei Pei, Changhong Yang, Shifeng Huang, Michael Wübbenhorst   +6 more
wiley   +1 more source

ERK builds a population of short-lived nascent adhesions that produce persistent edge protrusion and cell migration. [PDF]

Proc Natl Acad Sci U S A
Shepherd AP, Carney KR, Rostami M, Shawon J, Elliott A, Samson SC, Han SJ, Mendoza MC.   +7 more
europepmc   +1 more source

Porphyrin‐Based Porous Materials for Antibacterial Applications

Advanced Science, EarlyView.
Porphyrin‐based porous materials have excellent photophysical properties and tunable structures for high‐efficiency antibacterial therapy. This review comprehensively discusses the structural design strategies and synthetic pathways of the four main types of porphyrin‐based porous materials, summarizes their cross‐domain antimicrobial applications, and
Xiao‐Xue Liang, Xin Li, Ying Xiong, Xin Wang, Ying‐Wei Yang   +4 more
wiley   +1 more source

Human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosis. [PDF]

Sci Transl Med
Chueh HJ, Katsikoudi A, Aragón-González A, Lam CL, Tamon L, Jainarayanan A, Agarwal D, Cowley SA, Sims D, Tofaris GK.   +9 more
europepmc   +1 more source