Results 221 to 230 of about 77,925 (341)

Finite element simulations of the effect of friction coefficient in fretting wear [PDF]

, 2016
Abdel Wahab, Magd, Yue, Tongyan
core  

Therapeutic potential of small molecules that block receptor‐induced Kv7/M‐current suppression in neuroprotection, seizures, and pain

British Journal of Pharmacology, EarlyView.
Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim, Pavan Kumar Behara, Lamees Alhassen, Cindy Wong, Olivier Civelli, Naoto Hoshi   +5 more
wiley   +1 more source

Tribological Characterization of Carbon Fibre Reinforced Polymer (CFRP) Sliding Against Ti and Al Alloy Counterbodies for Aerospace Applications. [PDF]

Materials (Basel)
Vilhena L, Khan SA, Garcia A, Ramalho A.
europepmc   +1 more source

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

Microstructure Evolution and Fretting Wear Mechanisms of Steels Undergoing Oscillatory Sliding Contact in Dry Atmosphere. [PDF]

Materials (Basel)
Maich AA, Gronsky R, Komvopoulos K.
europepmc   +1 more source

A Computational Study on the Neck-Stem Rectangular Tapered Connection: Effects of Angular Mismatch, Assembly, and Cyclic Loading. [PDF]

Int J Numer Method Biomed Eng
Cromi R, Ciriello L, Berti F, La Barbera L, Villa T, Pennati G.   +5 more
europepmc   +1 more source

Molecular dynamics simulations and fluorescence spectroscopy suggest reduced tryptophan‐to‐heme energy transfer facilitates lignin degradation in ClassII peroxidases

The FEBS Journal, EarlyView.
In lignin peroxidase and versatile peroxidase, low FRET from buried Trp to heme promotes long‐range electron transfer (LRET) from substrate to heme. This efficient electron flow is facilitated by reduced FRET competition. This mechanism likely evolved to enable the effective degradation of bulky, high‐redox‐potential lignin that cannot reach the enzyme'
Yi Ren, Dale Ang, Haluk Ertan, Anne Poljak, Janice R. Aldrich‐Wright, Wallace J. Bridge, Khawar Sohail Siddiqui   +6 more
wiley   +1 more source

Bolt loosening evaluation method based on normalized screw root equivalent stress and loosening life curve. [PDF]

Sci Rep
Yang G, Zhao H, Yang L, Shao W, Xiao S, Zhu T, Yuan Y.   +6 more
europepmc   +1 more source

Multiaxial Fatigue Behavior of AA6016 and AA6016 to DX54D SPR Joints: Fracture Mechanisms and Data‐Driven Rupp's Model

Fatigue &Fracture of Engineering Materials &Structures, EarlyView.
ABSTRACT The fatigue and fracture behavior of self‐piercing rivet (SPR) joints between AA6016 aluminum sheets (1–2 mm) and DX54D steel (0.95 mm) was studied under 90°, 45°, and 0° multiaxial loading. Pure shear (90°) loading produced the highest fatigue strength, whereas multiaxial (45°) loading resulted in reduced performance, with pure tension (0 ...
Alan Woo, Amelie Malpot, Behzad Behravesh, Saeid Rezaee, Amirsalar Anousheh, Hamid Jahed   +5 more
wiley   +1 more source