Results 51 to 60 of about 11,293,464 (295)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A comparison between single sided and double sided friction stir welded 8mm thick DH36 steel plate [PDF]

, 2012
As part of an ongoing process to fully evaluate the potential for friction stir welding (FSW) to be used in the shipbuilding industry, a comparison has been made between two variants of the process.
Osman, M.M., Cater, Stephen R., Galloway, Alexander, McPherson, Norman   +3 more
core   +2 more sources

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Frictional Behavior of Natural Granite Gouges at Hydrothermal Conditions With Varied Initial Grain Size

Geophysical Research Letters
Fine‐grained gouge found in fault cores controls earthquake generation through its frictional behavior and microstructural evolution. Here we present friction experiments on natural granitic gouges of various initial grain sizes at hydrothermal ...
Huiru Lei, Yongsheng Zhou, André R. Niemeijer, Jianye Chen, Christopher J. Spiers   +4 more
doaj   +1 more source

Holistic Measurement of the Friction Behavior of Wet Clutches

Lubricants
The safe and efficient torque transmission of wet disk clutch systems requires high coefficients of friction. To achieve good controllability and high comfort, a positive slope of the coefficient of friction over sliding velocity is ensured by a ...
Patrick Strobl, Georg Johann Meingassner, Hermann Pflaum, Katharina Voelkel, Thomas Schneider, Karsten Stahl   +5 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Running-In Behavior and Failure Mechanism Between AgCuNi Alloy and Au-Electroplated Layer

Sensors
To avoid wear and tear of the slip ring due to electrical corrosion, the slip ring needs to undergo the running-in process under atmospheric conditions without current after assembly.
Hongjian Wu, Ya’nan Zhang, Qingjian Jia, Hui Cao, Han Li, Ming Ma   +5 more
doaj   +1 more source

Friction and Temperature Behavior of Lubricated Thermoplastic Polymer Contacts

Lubricants, 2020
This work focuses on the friction and temperature behavior of thermo-elastohydrodynamically lubricated (TEHL) contacts under rolling-sliding conditions.
Stefan Reitschuster, Enzo Maier, Thomas Lohner, Karsten Stahl   +3 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source