Results 31 to 40 of about 5,248,948 (284)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Investigation of tribological, physicomechanical, and morphological properties of resin-based friction materials reinforced with Agave americana waste

Materials Research Express, 2021
In recent years, natural fibers and their composites have attracted the attention of researchers due to environmental awareness and sustainable development.
Siyang Wu, Jian Zhuang, Qian Wu, Hongyan Qi, Jiale Zhao, Mingzhuo Guo   +5 more
doaj   +1 more source

Damage mechanism of Fe-based powder metallurgy friction materials in high energy braking

Fenmo yejin jishu, 2023
Fe-based powder metallurgy friction materials were prepared by powder metallurgy pressure sintering technology, and the damage mechanism of the friction materials under the high energy braking conditions as the speed of 7500 r·min−1, the surface pressure
ZHANG Nan, XU Yan, HAN Ming, DU Jianhua, MA Ling, HAN Junjiao, JI Zhen   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Forming control and the relationship between microstructure and mechanical property in TIG-assisted friction stir welded joint of Ti-6Al-3Nb-2Zr-1Mo titanium alloy

Journal of Materials Research and Technology
In this paper, T-joints of Ti-6Al-3Nb-2Zr-1Mo titanium alloy were joined with friction stir welding, and microstructure evolution and forming mechanism were studied.
Xiawei Yang, Mingxuan Yao, Yu Su, Tingxi Meng, Shitong Ma, Zhenguo Guo, Wenwei Zhao, Tiejun Ma, Wenya Li   +8 more
doaj   +1 more source

Dual laser-beam synchronous self-fusion welding of Ti–6Al–4V titanium alloys T-joints based on prefabricated welding materials

Journal of Materials Research and Technology, 2022
Aiming at the difficulty of feeding filler wire in the dual laser-beam synchronous welding (DLSW) of Ti–6Al–4V titanium alloys T-joints, the self-fusion DLSW process based on prefabricated welding materials on the stringer was developed.
Yahui Wu, Yue Mao, Li Fu, Dingqiang Qin, Xuan Xiao   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The effect of inclusions and pores on creep crack propagation of linear friction welded joints of GH4169 superalloy

Journal of Materials Research and Technology
Superalloy has become the key material in components of blisks for aero-engines produced by linear friction welding. However, during the long-term service of the blisks, stress rupture occurs on the blisk under long-term creep.
Xiawei Yang, Tingxi Meng, Yu Su, Xinyuan He, Zhenguo Guo, Dong Wu, Tiejun Ma, Wenya Li   +7 more
doaj   +1 more source

Verification of tribo-reduction of copper oxide in phenolic composite material through visualization of friction surface

Nihon Kikai Gakkai ronbunshu, 2018
The surface of phenolic composite material was continuously observed through borosilicate glass (BK7) during friction to verify the tribo-reduction of copper oxide (CuO) taking place at the interface. Two types of pad samples were slid against a rotating
Katsuya OKAYAMA, Ken'ichi HIRATSUKA
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source