Results 31 to 40 of about 447,948 (298)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Addiction Science & Clinical PracticeBackground Individuals with substance use disorders (SUDs) frequently use acute hospital services. The Navigation Services to Avoid Rehospitalization (NavSTAR) trial found that a patient navigation intervention for hospitalized patients with comorbid ...
Courtney D. Nordeck +6 more
doaj +1 more source
How international students can well understand adapted online collaboration project? The case of BIPA learners [PDF]
Journal of Pedagogical ResearchExploring and adapting learning development has been fascinating in recent decades. One is project-based online intercultural collaborative learning for international BIPA students in Thailand.
Wahyudi Rahmat +3 more
doaj +1 more source
School refusal and school-related differences among students with and without diagnoses
Nordisk tidsskrift for pedagogikk og kritikk, 2022 School refusal is an increasing concern in the Nordic countries. In Norway, public recommendations to combat school refusal sometimes include making life at home less desirable, which reflects the notion that children choose to stay at home out of ...
Marie-Lisbet Amundsen +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Journal of Family Medicine and Primary Care, 2016 This commentary is the result of a long-distance creative writing project between young general practitioners (GPs) from around the world. They wrote this after participating in an exchange program in Turkey, where they had the opportunity to shadow a ...
Indra Van Hoorick +5 more
doaj +1 more source