Results 51 to 60 of about 3,525,094 (305)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Institutional and Students’ Factors Influencing Adoption of E-Learning in Higher Educational Institutions in Kenya: A Case of Public Universities

open access: yesIndonesian Journal of Educational Research and Review
E-learning as a crucial aspect of ICT is a new model of education dispensation in the Higher Educational Institutions (HEIs) across the world. However, this technologically enhanced educational model is still at the infancy stage in the developing ...
Amos Otieno Wanjara, Paul Okeyo Ogembo
doaj   +1 more source

Risk Cluster Associated with Social Drinking in Adolescence [PDF]

open access: yesJournal of Biomedical & Clinical Research, 2016
Recent scientific evidence has shown that risk behaviors tend to form a risk cluster, but less attention is paid to clustering ability of light forms of risky behavior like social drinking.
Galya Chamova, Georgi Sarov
doaj   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Peer-Led Care Practices and ‘Community’ Formation in British Retirement Migration

open access: yesNordic Journal of Migration Research, 2017
This article uses ethnography of British retirement migration in Spain to explore how care practices among migrant peers operationalize ‘community’ in place.
Caroline Oliver
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Impact of Situational Analysis on Implementation of Educational Innovations in Kenya: The Case of Competency Based Curriculum (CBC)

open access: yesIndonesian Journal of Educational Research and Review
Educational innovation is inevitable in every society. A shift from 8:4:4 to 2:6:3:3:3 (CBC) system of education is ongoing and the new curriculum is taking a centre stage.
Amos Otieno Wanjara, Paul Okeyo Ogembo
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

An algorithm for identifying the best current friend in a social network

open access: yesIngeniería e Investigación, 2015
A research field in the area of social networks (SNs) is the identification of some types of users and groups. To facilitate this process, a SN is usually represented by a graph.
Francisco Javier Moreno   +1 more
doaj   +1 more source

Why Most Facebook Users Get More Than They Give [PDF]

open access: yes, 2012
Analyzes data on Facebook user activity, including patterns in sending friend requests, adding content, and "liking" their friends' content; the interconnectedness of friends; and links between the number of friends, Facebook activity, and social ...
Cameron Marlow   +3 more
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