Mechanistic models are critical for our understanding of both within-host dynamics (i.e., pathogen replication and immune system processes) and among-host dynamics (i.e., transmission). Within-host models, however, are not often fit to experimental data,
Joseph R. Mihaljevic +2 more
doaj +1 more source
The evolution, distribution and diversity of endogenous circoviral elements in vertebrate genomes [PDF]
Circoviruses (family Circoviridae) are small, non-enveloped viruses that have short, single-stranded DNA genomes. Circovirus sequences are frequently recovered in metagenomic investigations, indicating that these viruses are widespread, yet they remain ...
Dennis, Tristan P.W. +5 more
core +1 more source
Mitochondrial DNA from hamster tumors induced by adenovirus type 12 [PDF]
1. Mitochondria isolated from hamster tumors induced by adenovirus type 12 possessed circular DNA fibers. 2. The mean value of the length of the highest frequency group of the circular DNA molecules was 4.92 ±0.38 μ. 3. Catenated dimer DNA molecules
Nishida, Shigeru, Oda, Takuzo
core +1 more source
In vivo therapeutic efficacy of frog skin-derived peptides against Pseudomonas aeruginosa-induced pulmonary infection [PDF]
Pseudomonas aeruginosa is an opportunistic and frequently drug-resistant pulmonary pathogen especially in cystic fibrosis sufferers. Recently, the frog skin-derived antimicrobial peptide (AMP) Esc(1-21) and its diastereomer Esc(1-21)-1c were found to ...
Chen, Chen +2 more
core +1 more source
Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells
ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch +7 more
wiley +1 more source
Ranaviruses in captive and wild Australian lizards
Ranaviral infections have been associated with mass mortality events in captive and wild amphibian, fish, and reptile populations globally. In Australia, two distinct types of ranaviruses have been isolated: epizootic haematopoietic necrosis virus in ...
Alicia Maclaine +4 more
doaj +1 more source
The Immunoglobulins of Cold-Blooded Vertebrates [PDF]
Peer reviewedPublisher ...
Chen +22 more
core +2 more sources
The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke +2 more
wiley +1 more source
Immune Evasion Strategies of Ranaviruses and Innate Immune Responses to These Emerging Pathogens
Ranaviruses (RV, <em>Iridoviridae</em>) are large double-stranded DNA viruses that infect fish, amphibians and reptiles. For ecological and commercial reasons, considerable attention has been drawn to the increasing prevalence of ranaviral ...
Leon Grayfer +4 more
doaj +1 more source
Discovery of granulocyte-lineage cells in the skin of the amphibian Xenopus laevis
The ranavirus Frog Virus 3 (FV3) and the chytrid fungus Batrachochytrium dendrobatidis (Bd) are significant contributors to the global amphibian declines and both pathogens target the amphibian skin.
Kelsey Hauser +8 more
doaj +1 more source

