Results 101 to 110 of about 489,621 (291)
A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43
Advanced Science, EarlyView.Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg +16 more
wiley +1 more source
Pathological regional blood flow in opiate-dependent patients during withdrawal: A HMPAO-SPECT study [PDF]
, 1998 The aims of the present study were to investigate regional cerebral blood flow (rCBF) in heroin-dependent patients during withdrawal and to assess the relation between these changes and duration of heroin consumption and withdrawal data.
Krappel, C. +9 more
core +1 more source
Advanced Science, EarlyView.This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang +22 more
wiley +1 more source
Age-related Differences in Implicit Sequence Learning and Consolidation across the Human Life Span: Implications for the Functioning of the Fronto-Striatal Circuitry [PDF]
, 2012 Implicit sequence learning occurs when information is acquired from an environment of complex stimuli without conscious access either to what was learned or to the fact that learning occurred.
Janacsek Karolina
core
Executive dysfunction in autism [PDF]
, 2004 ‘Executive function’ is an umbrella term for functions such as planning, working memory, impulse control, inhibition and mental flexibility, as well as for the initiation and monitoring of action. The primacy of executive dysfunction in autism is a topic
Hill, Elisabeth L.
core +1 more source
Advanced Science, EarlyView.Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li +10 more
wiley +1 more source
Advanced Science, EarlyView.How can humanity achieve lunar self‐sufficiency? We utilize Au topology networks to modify the abundant lunar ilmenite. This catalyst, under sunlight, can convert waste carbon dioxide into space fuel. This design leverages the moon's natural vacuum for green manufacturing, avoiding the waste of gold and serving as “artificial chloroplasts” to sustain ...
Yahang Wang +9 more
wiley +1 more source
Parallel encoding of speech in human frontal and temporal lobes
Nature CommunicationsModels of speech perception are centered around a hierarchy in which auditory representations in the thalamus propagate to primary auditory cortex, then to the lateral temporal cortex, and finally through lateral cortical areas to reach the frontal lobe.
Patrick W. Hullett +4 more
doaj +1 more source