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Pharmacotherapy for Frontotemporal Dementia
CNS Drugs, 2021Frontotemporal dementia is a heterogeneous spectrum of neurodegenerative disorders. The neuropathological inclusions are tau proteins, TAR DNA binding protein 43 kDa-TDP-43, or fused in sarcoma-ubiquitinated inclusions. Genetically, several autosomal mutations account for the heritability of the disorder.
Rita Khoury +3 more
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Autoimmunity and Frontotemporal Dementia
Current Alzheimer Research, 2018Background: Frontotemporal Dementia (FTD) is a neurodegenerative disorder which asymmetrically affects the frontotemporal lobe, characterized by behavioural abnormalities, language impairment, and deficits of executive functions. Genetic studies identified mutations causing the disease, namely Microtubule Associated Protein Tau (MAPT), Granulin (GRN)
Alberici A. +5 more
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Neuroimaging in frontotemporal dementia
International Review of Psychiatry, 2013The term frontotemporal dementia (FTD) refers to a group of neurodegenerative disorders that are associated with atrophy of the frontal and temporal lobes, and present clinically with impairments of behaviour or language. Three main subtypes are described, behavioural variant FTD (bvFTD) and two subtypes of the language presentation (known as primary ...
Jonathan D. Rohrer, Howard J. Rosen
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Psychosis in Frontotemporal Dementia
Journal of Alzheimer's Disease, 2014Frontotemporal dementia (FTD) is a neurodegenerative disorder, associated with a progressive decline in behavior caused by focal degeneration of the frontal lobes. Psychosis was an underestimated symptom of FTD, however, recent genetic research has revealed a high prevalence of psychosis in certain genetic groups.
Ariel Graff-Guerrero +6 more
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Continuum
This article discusses frontotemporal dementia (FTD) syndromes using a simplified framework of three core syndromes, including details on their pathology and unique genetic variations.FTD includes at least seven major clinical syndromes. The three core syndromes are behavioral variant FTD and two forms of progressive aphasia, commonly referred to as ...
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This article discusses frontotemporal dementia (FTD) syndromes using a simplified framework of three core syndromes, including details on their pathology and unique genetic variations.FTD includes at least seven major clinical syndromes. The three core syndromes are behavioral variant FTD and two forms of progressive aphasia, commonly referred to as ...
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The genetics of frontotemporal dementia
2008Publisher Summary This chapter emphasizes that frontotemporal dementia (FTD) is the second most common form of primary degenerative dementia after Alzheimer's disease (AD). The onset of the disease is most commonly in middle age between 45 and 65 years.
Pickering-Brown, Stuart, Hutton, Michael
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Neuroinflammation in frontotemporal dementia
Nature Reviews Neurology, 2019Frontotemporal dementia (FTD) refers to a group of progressive neurodegenerative disorders with different pathological signatures, genetic variability and complex disease mechanisms, for which no effective treatments exist. Despite advances in understanding the underlying pathology of FTD, sensitive and specific fluid biomarkers for this disease are ...
Michael Kassiou +14 more
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Survival in frontotemporal dementia
Neurology, 2003To establish survival in patients with pathologically confirmed frontotemporal dementia (FTD) and to determine whether clinical or pathologic subtype affects prognosis.The authors reviewed the presenting clinical features of 61 patients with dementia and pathologically confirmed FTD studied in Sydney (n = 31) and Cambridge (n = 30) over a 10-year ...
R. Rhys Davies +4 more
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