Results 41 to 50 of about 329,751 (255)

Apraxia profiles—A single cognitive marker to discriminate all variants of frontotemporal lobar degeneration and Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction Apraxia is common in neurodegenerative dementias but underrepresented in clinical workup for differential diagnoses. Methods Praxis‐profiles were assessed with the Dementia Apraxia Test in 93 patients with early stages of biologically ...
Andreas Johnen, Sophia Reul, Heinz Wiendl, Sven G. Meuth, Thomas Duning   +4 more
doaj   +1 more source

A case of familial frontotemporal dementia caused by a progranulin gene mutation

Clinical Parkinsonism & Related Disorders, 2023
After Alzheimer’s disease, Frontotemporal dementia (FTD) is the most common cause of early-onset dementia. Several genetic mutations have been identified in familial FTD, with mutations in progranulin (GRN) accounting for approximately 20–25% of familial
Lauryn Currens, Nigel Harrison, Maria Schmidt, Halima Amjad, Weiyi Mu, Sonja W. Scholz, Jee Bang, Alexander Pantelyat   +7 more
doaj   +1 more source

Total and phosphorylated tau proteins: Evaluation as core biomarker candidates in frontotemporal dementia [PDF]

, 2004
An ever increasing number of patients with neurodegenerative disorders calls for the evaluation of potential diagnostic markers that allow an early diagnosis and an early initiation of specific therapy. Clinical diagnosis of Alzheimer's disease (AD), the
Teipel, S. J., Hampel, H., Harald Hampel, Stefan J. Teipel   +3 more
core   +1 more source

Inheritance of Frontotemporal Dementia [PDF]

Archives of Neurology, 1999
Previous studies of families with fronto-temporal dementia (FTD) support an autosomal dominant inheritance pattern, but most studies have described genetic transmission in individual families specifically selected for the presence of multiple affected individuals.To investigate the familial presentation and inheritance of FTD and related disorders ...
T W, Chow, B L, Miller, V N, Hayashi, D H, Geschwind   +3 more
openaire   +2 more sources

White matter tract damage in the behavioral variant of frontotemporal and corticobasal dementia syndromes.

PLoS ONE, 2014
The phenotypes of the behavioral variant of frontotemporal dementia and the corticobasal syndrome present considerable clinical and anatomical overlap.
Fernanda Tovar-Moll, Ricardo de Oliveira-Souza, Ivanei Edson Bramati, Roland Zahn, Alyson Cavanagh, Michael Tierney, Jorge Moll, Jordan Grafman   +7 more
doaj   +1 more source

Phenocopy syndrome of frontotemporal dementia

European Psychiatry, 2021
Introduction Frontotemporal dementia (FTD) is a group of neurodegenerative disorders characterized by behavioral or language changes with progressive executive dysfunction. It´s subdivided into two variants, the behavioral and language variants.
D. Martins, R. Faria, M. Pinho, S. Rodrigues   +3 more
doaj   +1 more source

The Calcium-Binding Protein EFhd2 Modulates Synapse Formation In Vitro and Is Linked to Human Dementia [PDF]

, 2014
EFhd2 is a calcium-binding adaptor protein that has been found to be associated with pathologically aggregated tau in the brain in Alzheimer disease and in a mouse model of frontotemporal dementia.
Gunn-Moore, Frank J, Mann, David, Spires-Jones, Tara, Borger, Eva, Herrmann, Abigail, Gunn-Moore, Frank, Spires-Jones , Tara, Mann, David A, Gunn-Moore, Frank J; id_orcid, Borger, Eva; id_orcid   +9 more
core   +1 more source

Frontotemporal Dementias [PDF]

Continuum, 2016
This article reviews the common behavioral and cognitive features of frontotemporal dementia (FTD) and related disorders as well as the distinguishing clinical, genetic, and pathologic features of the most common subtypes.Advances in clinical phenotyping, genetics, and biomarkers have enabled improved predictions of the specific underlying molecular ...
openaire   +2 more sources

Mixed Brain Pathologies in Dementia: The BrainNet Europe Consortium Experience [PDF]

, 2008
Background: Dementia results from heterogeneous diseases of the brain. Mixed disease forms are increasingly recognized. Methods: We performed a survey within brain banks of BrainNet Europe to estimate the proportion of mixed disease forms underlying ...
Gelpi, Ellen, Kretzschmar H, Alafuzoff, Irina, Alafuzoff I, Budka H., Nagy, Zoltan, Seilhean, Danielle, Ferrer I, Arzberger, Thomas, Al-Sarraj, Safa, Gelpi E, Kovacs, Gabor G., Kretzschmar, Hans, Soininen, Hilkka, Troakes, Claire, Nagy Z, Capellari, Sabina, Seilhean D, Kövari V, Budka, Herbert, Al Sarraj S, Troakes C, Alafuzoff, Irina,, Arzberger T, Ferrer, Isidro, Bogdanovic, Nenad, Bogdanovic N, Kovari, Viktor, Soininen H, Parchi, Piero, Kovacs GG, Ferrer, I, Alafuzoff, I, Capellari, S, Kovacs, GG, Gelpi, E, Al-Sarraj, S, Bogdanovic, N,, Kovari, V, Arzberger, T, Kretzschmar, H   +40 more
core   +1 more source

Mislocalization of FTD3-associated mutant CHMP2B to the nucleus of human neurons due to loss of a nuclear export signal

Acta Neuropathologica Communications
Frontotemporal dementia linked to chromosome 3 (FTD3) is caused by a splice site point mutation in CHMP2B, resulting in the production of mutant proteins CHMP2BIn5 and CHMP2BΔ10.
Yong-Woo Jun, Evan P. Hass, Soojin Lee, Thomas G. Fazzio, Fen-Biao Gao   +4 more
doaj   +1 more source