Results 111 to 120 of about 24,976 (233)

Peripheral Innate Immune Activation Correlates With Disease Severity in GRN Haploinsufficiency. [PDF]

, 2019
Objective: To investigate associations between peripheral innate immune activation and frontotemporal lobar degeneration (FTLD) in progranulin gene (GRN) haploinsufficiency. Methods: In this cross-sectional study, ELISA was used to measure six markers of
Allen, Isabel Elaine, Boxer, Adam L, Cobigo, Yann, Heuer, Hilary, Karydas, Anna, Kramer, Joel H, Ljubenkov, Peter A, McGrath, Michael S, Miller, Bruce, Miller, Zachary, Mitic, Laura, Mumford, Paige, Pearlman, Rodney, Rojas, Julio C, Rosen, Howard J, Staffaroni, Adam, Zhang, Jane   +16 more
core   +2 more sources

Exploring the role of brain DNA methylomic signatures on gene expression dynamics of frontotemporal lobar degeneration [PDF]

, 2023
Katerine Fodder, Megha Murthy, Patrizia Rizzu, Christina E. Toomey, Rahat Hasan, Jack Humphrey, Towfique Raj, Katie Lunnon, Jonathan Mill, Peter Heutink, Tammaryn Lashley, Conceição Bettencourt   +11 more
openalex   +1 more source

Expanding the Phenotype of Frontotemporal Lobar Degeneration With FUS-Positive Pathology (FTLD-FUS) [PDF]

, 2020
Karina Chornenka, Veronica Hirsch‐Reinshagen, Mari Perez‐Rosendahl, Howard Feldman, Freddi Segal‐Gidan, Harry V. Vinters, Ian R. Mackenzie   +6 more
openalex   +1 more source

A Case of Frontotemporal Lobar Degeneration with Progressive Dysarthria

Behavioural Neurology, 2006
We investigated the evolution of the neurological and neuropsychological characteristics in a right-handed woman who was 53-years-old at the onset and who showed personality changes and behavioral disorders accompanied by progressive dysarthria.
Nami Ihori, Shigeo Araki, Kenji Ishihara, Mitsuru Kawamura   +3 more
doaj   +1 more source

Neuroanatomical profiles of personality change in frontotemporal lobar degeneration [PDF]

, 2011
Colin Mahoney, Jonathan D. Rohrer, Rohani Omar, Martin N. Rossor, Jason D. Warren   +4 more
openalex   +1 more source

Molecular Pathways Bridging Frontotemporal Lobar Degeneration and Psychiatric Disorders

Frontiers in Aging Neuroscience, 2016
The overlap of symptoms between neurodegenerative and psychiatric diseases has been reported. Neuropsychiatric alterations are commonly observed in dementia, especially in the behavioral variant of frontotemporal dementia (bvFTD), which is the most ...
Roberta eZanardini, Miriam eCiani, Luisa eBenussi, Roberta eGhidoni   +3 more
doaj   +1 more source

Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia

Neurobiology of Disease
Loss-of-function mutations affecting the lysosomal protein progranulin are a leading cause of frontotemporal dementia. Progranulin mutations cause abnormalities in lysosomal lipid processing, particularly of sphingolipids, major components of neural cell
Nicholas R. Boyle, Stephanie N. Fox, Aniketh S. Tadepalli, Nicholas T. Seyfried, Thomas Kukar, Eliana M. Ramos, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant, Erik D. Roberson   +12 more
doaj   +1 more source

Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies [PDF]

, 2018
Accumulation of hyperphosphorylated, ubiquitinated and N-terminally truncated TAR DNA-binding protein (TDP-43) is the pathological hallmark lesion in most familial and sporadic forms of FTLD-U and ALS, which can be subsumed as TDP-43 proteinopathies.
Flatley, Andrew, Forman, Mark, Kremmer, Elisabeth, Kretzschmar, Hans, Kwong, Linda, Lee, Edward, Lee, Virginia, Neumann, Manuela, Trojanowski, John, Troost, Dirk, Xu, Yan   +10 more
core  

Survival in the pre-senile dementia frontotemporal lobar degeneration with TDP-43 proteinopathy: effects of genetic, demographic and neuropathological variables [PDF]

, 2016
Richard A. Armstrong
openalex   +1 more source

Frontotemporal Lobar Degeneration

, 2011
Frontotemporal lobar degeneration (FTLD) comprises diseases with a very diverging spectrum in regards to clinical presentation, genetics, and neuropathology. In 1892 Arnold Pick published the case of 71-year old male with progressive symptoms of aphasia, apathy, and dementia (Pick 1892).
openaire   +3 more sources