Results 91 to 100 of about 23,647 (218)

Exploring Theory of Mind abilities in patients with probable idiopathic normal pressure hydrocephalus

Journal of Neuropsychology, EarlyView.
Abstract This study investigated Theory of Mind (ToM) deficits in patients with suspected idiopathic normal pressure hydrocephalus (iNPH), a condition affecting motor, cognitive and autonomic functions. Given the overlap between ToM‐related neural networks and those affected in iNPH, we examined whether ToM impairments are a feature of the disease ...
Akrivi Vatsi, George Stranjalis, Stylianos Gkatzonis, Christos Koutsarnakis, Eleftherios Neromyliotis, Aristotelis Kalyvas, Ion N. Beratis, Evangelos Drosos, Spyridon Komaitis, Evangelia Liouta   +9 more
wiley   +1 more source

Frontotemporal lobar degeneration: current perspectives

Neuropsychiatric Disease and Treatment, 2014
The term frontotemporal lobar degeneration (FTLD) refers to a group of progressive brain diseases, which preferentially involve the frontal and temporal lobes. Depending on the primary site of atrophy, the clinical manifestation is dominated by behavior alterations or impairment of language.
Kurz, Alexander, Riedl,Lina, Mackenzie,Ian, Förstl,Hans, Diehl-Schmid,Janine   +4 more
openaire   +4 more sources

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations [PDF]

, 2017
Accumulation of the DNA/RNA binding protein fused in sarcoma as cytoplasmic inclusions in neurons and glial cells is the pathological hallmark of all patients with amyotrophic lateral sclerosis with mutations in FUS as well as in several subtypes of ...
Ang, Lee-Cyn, Ansorge, Olaf, Bentmann, Eva, Bilbao, Juan, DeJesus-Hernandez, Mariely, Dormann, Dorothee, Haass, Christian, Jawaid, Ali, Kretzschmar, Hans A., Kusaka, Hirofumi, Mackenzie, Ian R. A., Munoz, David G., Neumann, Manuela, Rademakers, Rosa, Roeber, Sigrun, Yokota, Osamu   +15 more
core  

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions [PDF]

, 2014
Hexanucleotide repeat expansions in chromosome 9 open reading frame 72 (C9orf72) have recently been linked to frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis, and may be the most common genetic cause of both neurodegenerative ...
AD Kern, AE Renton, AL Boxer, Albert Llado, Alice S. Chen-Plotkin, Allan Levey, AM Nicholson, Andrew Lieberman, Ann McKee, Anna Antonell, AS Chen-Plotkin, AS Chen-Plotkin, AS Chen-Plotkin, AS Kondrashov, Bernardino Ghetti, BR Brooks, C Cruchaga, Carl Cotman, Carol A. Miller, Carol Dobson-Stone, Catriona McLean, Charles DeCarli, Charles L. White III, Christine Hulette, Christine Van Broeckhoven, Christopher J. McDermott, CM Lang, Danielle Seilhean, David G. Munoz, DM Weinreich, Douglas Galasko, Eliezer Masliah, Ellen Gelpi, EM Wijsman, Eunran Suh, G Skibinski, GD Watts, Glenda Halliday, GM McKhann, H Seelaar, H Stewart, Henry Paulson, I Gijselinck, I Litvan, Ilse Gijselinck, IR Mackenzie, Irina Alafuzoff, J Gass, J Zee van der, J. Robin Highley, Janine Kirby, Jason Warren, JB Toledo, Jean-Jacques Martin, Jill Murrell, Jillian Kril, John B. J. Kwok, John C. Van Swieten, John Hodges, John Q. Trojanowski, Johnathan Cooper-Knock, Jonathan D. Rohrer, Jordan Grafman, Josh Miller, JS Snowden, Julia Kofler, Julie Schneider, Julie van der Zee, K Mori, K Rascovsky, Kimmo J. Hatanpaa, Lauren Elman, Lee-Way Jin, Leo McCluskey, Lisa C. Silbert, M Cruts, M DeJesus-Hernandez, M Hutton, Manuela Neumann, Marc Cruts, Marla Gearing, Martin Rossor, Mary Sano, Matthew P. Frosch, MF Schenk, Michael D. Gallagher, MJ Strong, ML Gorno-Tempini, Murray Grossman, N Finch, Nenad Bogdanovic, Nick Fox, Nigel J. Cairns, OA Brady, Olivier Piguet, P Fratta, Pamela J. Shaw, Patrick Cras, Paul G. Ince, PE Ash, Peter P. De Deyn, Päivi Hartikainen, R Vass, Randall L. Woltjer, Raquel Sanchez-Valle, RF Silva, S Ciura, Safa Al-Sarraj, Salvatore Spina, Sebastiaan Engelborghs, Simon Mead, SS Shankaran, Stephen B. Wharton, SX Xie, Tim Van Langenhove, TP Levine, Virginia M. Y. Lee, Vivianna Van Deerlin, VM Deerlin Van, W Zhang, William Brooks   +120 more
core   +2 more sources

A Cross‐Disease Microglial Transcriptional Program Characterizes Neurodegeneration and Highlights SPP1 as a Biomarker

Glia, Volume 74, Issue 6, June 2026.
Distinct microglial subpopulations are depicted, highlighting variations in gene expression and functional roles in response to specific disease conditions and the complexity of microglial activation and differentiation in neurodegeneration. ABSTRACT Microglial cells are key players in maintaining brain homeostasis and responding to pathological ...
Alessandro Palma, Roberta Stefanelli, Francesco Trenta, Chiara Projetti, Greta Massa, Sonia Canterini, Maria Teresa Fiorenza   +6 more
wiley   +1 more source

A Case of Functional Movement Disorder Preceding Right Temporal Predominant Frontotemporal Degeneration

Movement Disorders Clinical Practice, EarlyView.
Isis So, Aditya Murgai, Elizabeth C. Finger, Miguel Restrepo‐Martinez   +3 more
wiley   +1 more source

Co‐pathologies and biological processes beyond amyloid‐beta and tau in people with Alzheimer's disease: Evidence from clinical cohort studies

Journal of Internal Medicine, Volume 299, Issue 6, Page 694-710, June 2026.
Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Daniel Ferreira, Tomasz Chmiela, Maria Eriksdotter, Clifford R. Jack Jr., Grégoria Kalpouzos, Anna Marseglia, Patrizia Mecocci, Agneta Nordberg, Dorota Religa, Eric Westman   +9 more
wiley   +1 more source

Phenotypic heterogeneity of monogenic frontotemporal dementia

Frontiers in Aging Neuroscience, 2015
Frontotemporal dementia (FTD) is a genetically and pathologically heterogeneous disorder characterized by personality changes, language impairment and deficits of executive functions associated with frontal and temporal lobe degeneration.
Alberto eBenussi, Alessandro ePadovani, Barbara eBorroni   +2 more
doaj   +1 more source

Recent biomarker approaches in the diagnosis of frontotemporal lobar degeneration/Neurochemische Ansätze in der Diagnose der Frontotemporalen Lobärdegeneration [PDF]

, 2017
Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of syndromes with different symptoms. Frontotemporal lobar degeneration is mostly used as a clinical umbrella term for different diseases. In some clinical subtypes of the FTLD spectrum, a
Feneberg, Emily, Lehnert, Stefan, Neumann, Manuela, Otto, Markus, Steinacker, Petra   +4 more
core  

Digital seed amplification assay for TDP‐43 aggregate quantification in CSF

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Dementia is commonly caused by underlying pathologies driven by misfolded protein aggregates. Although dementia subtypes have distinct mechanisms, overlapping symptoms make diagnosis without biomarkers difficult. Misdiagnosis has previously hindered drug development by enrolling patients non‐specifically in trials.
Ella Borberg, Zoe Swank, Tal Gilboa, Lily A. Wickland Shearer, Arek V. Melkonian, Justin C. Rolando, David R. Walt, Andrew M. Stern   +7 more
wiley   +1 more source