Results 91 to 100 of about 14,742 (206)

Differential aspects of familiar people recognition disorders in right and left variants of semantic dementia: A critical review

Journal of Neuropsychology, EarlyView.
Abstract The aim of the present review will consist of discussing the different forms of familiar people recognition disorders observed in the right and left variants of semantic dementia. The review will start with a summary of the main cognitive models of familiar people recognition and of the neuroanatomical correlates of the processing stages ...
Guido Gainotti
wiley   +1 more source

Behavioral variant frontotemporal dementia in patients with previous severe mental illness: a systematic and critical review

Arquivos de Neuro-Psiquiatria
Objectives: To explore the relationship between severe/serious mental illness (SMI) and the behavioral variant of frontotemporal dementia (bvFTD), as the patterns of symptoms and cognitive performance that characterize both disorders share similarities.
Leandro Boson Gambogi, Henrique Cerqueira Guimarães, Leonardo Cruz De Souza, Paulo Caramelli   +3 more
doaj   +1 more source

Unravelling the Significance of Cystatin C and Bunina Bodies in Amyotrophic Lateral Sclerosis Pathogenesis

Neuropathology and Applied Neurobiology, Volume 52, Issue 4, August 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a fatal neurodegenerative disease primarily affecting motor neurons. Two key protein inclusions found in lower motor neurons serve as neuropathological hallmarks of the disease in human tissue: the TDP43‐positive inclusion and the cystatin C‐positive Bunina body.
Sarah M. Granger, Rosemary A. Staniforth, Asbjorg Osk Snorradottir, Johnathan Cooper‐Knock, Kurt J. De Vos, J. Robin Highley   +5 more
wiley   +1 more source

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) can be caused by autosomal‐dominant familial Alzheimer's disease (FAD) mutations in amyloid precursor protein (APP) or presenilin‐1 and 2, which form an enzyme substrate complex. KAT5 binds to the APP intracellular domain.
Greg A Cary, Jessica E. Young, Shannon E. Rose, Harald Frankowski, Heather Wilkins, Sai Sruthi Amirtha Ganesh, Julia Draper, Martin Darvas, Mark Bothwell, Suman Jayadev, Aquene N. Reid, Anna Greenwood, Allan I. Levey, Karina Leal, Gregory W. Carter, Jesse C. Wiley   +15 more
wiley   +1 more source

Establishing robust cognitive dimensions for characterization and differentiation of patients with Alzheimer's disease, mild cognitive impairment, frontotemporal dementia and depression [PDF]

, 2014
The diagnosis of mild cognitive impairment (MCI) and dementia requires detailed neuropsychological examinations. These examinations typically yield a large number of outcome variables, which may complicate the interpretation and communication of results.
Beck, Irene R., Andreas U. Monsch, Schmid, Nicole S., Irene R. Beck, Nicole S. Schmid, Manfred Berres, Berres, Manfred, Monsch, Andreas U.   +7 more
core   +1 more source

Biochemical and Immunohistochemical Associations of TDP‐43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer's Disease

Annals of Neurology, Volume 100, Issue 1, Page 193-205, July 2026.
Objective Immunohistochemically (IHC) measured transactive response DNA‐binding protein 43 (TDP‐43) inclusions are observed in Alzheimer's disease (AD) and are associated with medial temporal lobe atrophy. Accumulation of cryptic exons occurs in AD in response to TDP‐43 pathology.
Hossam Youssef, Rodolfo G. Gatto, Nikhil B. Ghayal, Virginia Estades Ayuso, Karen R. Jansen‐West, Judith A. Dunmore, Yuping Song, Mei Yue, Casey N. Cook, Michael DeTure, Bailey D. Rawlinson, Monica Castanedes‐Casey, Clifford R. Jack Jr, Ronald C. Petersen, Dennis W. Dickson, Leonard Petrucelli, Jennifer L. Whitwell, Mercedes Prudencio, Keith A. Josephs   +18 more
wiley   +1 more source

Alzheimer's Disease Co‐Pathology and Cognitive Impairment in Amyotrophic Lateral Sclerosis

Annals of Neurology, Volume 100, Issue 1, Page 123-138, July 2026.
Objectives Amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) share neuropathological features, including tau, amyloid, and TDP‐43 pathology. This study investigated whether AD‐related pathological changes are associated with cognitive impairment ALS. Methods Cerebrospinal fluid (CSF total‐tau, phosphorylated‐tau, beta‐amyloid) and plasma
Elisabeth Kasper, Annaliis Lehto, Alexandra Jürs, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Voigt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Annett Halle, Jochen Herms, Anja Schneider, Stefan Teipel, Johannes Prudlo, Manuela Neumann, Andreas Hermann   +29 more
wiley   +1 more source

Chromosome 9 ALS and FTD locus is probably derived from a single founder.

, 2012
We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations.
Shatunov, A., Rollinson, PS, DeJesus-Hernandez, M, Pentti J. Tienari, Boxer, A.L., Hardy, J, Laaksovirta, H., Morrison, Karen E., Hardy, J., Aleksey Shatunov, John C. van Swieten, Rademakers, R, Restagno, Gabriella, Boeve, B.F., Bryan J. Traynor, Rollinson, Pamela Sara, Karen E. Morrison, Al-Chalabi, A., Ian R. Mackenzie, Morris, Huw Rees, Traynor, BJ, Mariely DeJesus-Hernandez, Jesus-Hernandez, M., Mackenzie, I.R., Morrison, KE, Orrell, R.W., Pamela Sara Rollinson, Mackenzie, Ian R., Simón-Sánchez, J, Nalls, MA, van Swieten, J.C., Waite, Adrian, Javier Simón-Sánchez, Tienari, P.J., Boeve, Bradley F., Morrison, Karen, Nalls, Michael A., Restagno, G, Myllykangas, L, Boxer, Adam L., Waite, Adrian James, Ammar Al-Chalabi, Waite, A, Mora, G, Heutink, P, Boeve, BF, Traynor, Bryan J., Waite, A., Adam L. Boxer, Shatunov, Aleksey, Rosa Rademakers, DeJesus-Hernandez, Mariely, Mackenzie, IR, Nigel Williams, Pickering-Brown, S, Hannu Laaksovirta, Chiò, A, Schymick, J., Williams, N, Simón-Sánchez, Javier, Laaksovirta, Hannu, Mok, K, Laaksovirta, H, Adrian Waite, Shaw, Pamela J., Pickering-Brown, Stuart, Rademakers, Rosa, Heutink, Peter, Mok, K., van Swieten, JC, Tienari, PJ, Liisa Myllykangas, Peuralinna, T, Heutink, P., Rollinson, P.S., Morris, HR, Hardy, John, Schymick, J, Shatunov, A, John Hardy, Simon-Sanchez, J., Huw R. Morris, Gabriele Mora, Morris, H.R., Peuralinna, T., Rademakers, R., Morrison, K.E., Mora, G., Pickering-Brown, S., Peuralinna, Terhi, Chio', Adriano, Peter Heutink, Richard W. Orrell, Chio, A., Terhi Peuralinna, Morrison, Karen E.; id_orcid, Myllykangas, Liisa, Williams, Nigel, Bradley F. Boeve, Gabriella Restagno, Pamela J. Shaw, Orrell, RW, Traynor, B.J., Shatunov, Aleksey; id_orcid, Kin Mok, Nalls, M.A., Al-Chalabi, Ammar, Williams, N., Boxer, AL, Shaw, P.J., Myllykangas, L., Mok, Kin, Mora, Gabriele, Orrell, Richard W., Tienari, Pentti J., Adriano Chiò, Schymick, Jennifer, Morris, Huw R., Shaw, PJ, Williams, Nigel Melville, Al-Chalabi, A, Chiò, Adriano, Restagno, G., van Swieten, John C., Michael A. Nalls, Stuart Pickering-Brown, Jennifer Schymick   +126 more
core   +1 more source

Poly‐GP in cerebrospinal fluid links C9orf72‐associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD [PDF]

, 2017
The C9orf72 GGGGCC repeat expansion is a major cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). Non‐conventional repeat translation results in five dipeptide repeat proteins (DPRs), but their clinical utility, overall ...
Edbauer, D., Otto, M., Lehmer, C., Fassbender, K., Ludolph, A., Landwehrmeyer, B., Steinacker, P., Schroeter, M.L., Kremmer, E., Diehl-Schmid, J., Schludi, M.H., Ludolph, A.C., Flatley, A., Volk, A., Kornhuber, J., Schludi, M., Arzberger, T., Volk, A.E., Weydt, P., Levin, J., Lauer, M., Weishaupt, J., Weishaupt, J.H., Oeckl, P., Feederle, R., Schroeter, M. ; https://orcid.org/   +25 more
core   +1 more source

Description of a priest in a medieval Japanese essay, "Tsurezuregusa": is this the first report of frontotemporal dementia? [PDF]

Dementia & Neuropsychologia
. In Tsurezuregusa, a medieval Japanese essay written by Kenkō, a priest with the characteristics of behavioral variant frontotemporal dementia (bvFTD), has been described.
Yuichiro Inatomi, Minoru Matsuda
doaj   +2 more sources