Results 91 to 100 of about 201,352 (177)
Aging Cell, Volume 25, Issue 10, October 2026.This study found that aging‐related cognitive impairment is accompanied by hippocampal microglial senescence. Ghrelin suppresses microglial senescence by promoting autophagy through the SHBG/JNK1/Beclin1 axis, thereby alleviating aging‐related cognitive impairment. The graphical abstract was drawn using the Figdraw.
Lixing Zhou +9 more
wiley +1 more source
Phenotypic heterogeneity of monogenic frontotemporal dementia
Frontiers in Aging Neuroscience, 2015 Frontotemporal dementia (FTD) is a genetically and pathologically heterogeneous disorder characterized by personality changes, language impairment and deficits of executive functions associated with frontal and temporal lobe degeneration.
Alberto eBenussi +2 more
doaj +1 more source
Synaptic Proteostasis in Health and Disease
Journal of Neurochemistry, Volume 170, Issue 10, October 2026.The localised creation and degradation of proteins at the pre and postsynaptic terminal are processes that are crucial for neuronal homeostasis. Synaptic proteostasis pathways are frequently reported as dysregulated in neurodevelopmental and neurodegenerative disorders.
Paul G. Donlin‐Asp, Emma L. Clayton
wiley +1 more source
Structural connectivity in a single case of progressive prosopagnosia: The role of the right inferior longitudinal fasciculus [PDF]
, 2014 Progressive prosopagnosia (PP) is a clinical syndrome characterized by a progressive and selective inability to recognize and identify faces of familiar people. Here we report a patient (G.S.) with PP, mainly related to a prominent deficit in recognition
Quarantelli M +13 more
core +1 more source
Arquivos de Neuro-PsiquiatriaObjectives: To explore the relationship between severe/serious mental illness (SMI) and the behavioral variant of frontotemporal dementia (bvFTD), as the patterns of symptoms and cognitive performance that characterize both disorders share similarities.
Leandro Boson Gambogi +3 more
doaj +1 more source
Description of a priest in a medieval Japanese essay, "Tsurezuregusa": is this the first report of frontotemporal dementia? [PDF]
Dementia & Neuropsychologia. In Tsurezuregusa, a medieval Japanese essay written by Kenkō, a priest with the characteristics of behavioral variant frontotemporal dementia (bvFTD), has been described.
Yuichiro Inatomi, Minoru Matsuda
doaj +2 more sources
A Case of Frontotemporal Lobar Degeneration with Progressive Dysarthria
Behavioural Neurology, 2006 We investigated the evolution of the neurological and neuropsychological characteristics in a right-handed woman who was 53-years-old at the onset and who showed personality changes and behavioral disorders accompanied by progressive dysarthria.
Nami Ihori +3 more
doaj +1 more source
Molecular Pathways Bridging Frontotemporal Lobar Degeneration and Psychiatric Disorders
Frontiers in Aging Neuroscience, 2016 The overlap of symptoms between neurodegenerative and psychiatric diseases has been reported. Neuropsychiatric alterations are commonly observed in dementia, especially in the behavioral variant of frontotemporal dementia (bvFTD), which is the most ...
Roberta eZanardini +3 more
doaj +1 more source
Guilty by suspicion? Criminal behavior in frontotemporal lobar degeneration.
, 2013 Our aim was to compare the frequency of criminal conduct in patients with behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SD), and Alzheimer disease.A few small-scale studies of antisocial and criminal behavior in patients with ...
Diehl-Schmid, Janine;Perneczky, Robert;Koch, Julia;Nedopil, Norbert;Kurz, Alexander
core +1 more source
Neurobiology of DiseaseLoss-of-function mutations affecting the lysosomal protein progranulin are a leading cause of frontotemporal dementia. Progranulin mutations cause abnormalities in lysosomal lipid processing, particularly of sphingolipids, major components of neural cell
Nicholas R. Boyle +12 more
doaj +1 more source