Results 71 to 80 of about 201,352 (177)

α‐Synuclein strain homogeneity in multiple system atrophy subtypes

Brain Pathology, EarlyView.
Two different subtypes of multiple system atrophy are recognized: MSA‐C and MSA‐P. In this manuscript, Lau et al. investigate whether MSA‐C and MSA‐P are caused by different strains of α‐synuclein aggregates. By performing conformational fingerprinting experiments as well as in vitro and in vivo seeding assays, their findings suggest that both MSA‐C ...
Heather H. C. Lau, Nicholas R. G. Silver, Surabhi Mehra, Raphaella W. L. So, Le yao Li, Alison Mao, Erica Stuart, Cian Schmitt‐Ulms, Bradley T. Hyman, Martin Ingelsson, Joel C. Watts   +10 more
wiley   +1 more source

Mini social cognition and emotional assessment: Diagnostic performance and neural correlates in behavioural‐variant frontotemporal dementia

Journal of Neuropsychology, EarlyView.
Abstract We aimed at validating the Mini Social Cognition and Emotional Assessment (Mini‐SEA) in a German cohort of mildly impaired behavioural‐variant frontotemporal dementia (bvFTD) patients and healthy controls. The Mini‐SEA comprises the Facial Emotion Recognition Test (FERT) and the Faux Pas Test (FPT) measuring Theory of Mind (ToM) abilities in ...
Cem Doğdu, Neeraj Upadhyay, Ingo Frommann, Luca Kleineidam, Andreas Johnen, Melina Stark, Sandra Roeske, Annika Spottke, Anna Gamez, Gabor C. Petzold, Louise Droste zu Senden, Julian Hellmann‐Regen, Stefan Hetzer, Klaus Fliessbach, Carolin Miklitz, Emrah Düzel, Falk Lüsebrink, Wenzel Glanz, Stefan Teipel, Ingo Kilimann, Josef Priller, Eike Jakob Spruth, Johannes Prudlo, David Mengel, Klaus Scheffler, Matthis Synofzik, Anja Schneider, Michael Wagner   +27 more
wiley   +1 more source

Early onset frontotermporal dementia and alzheimers disease: diagnosis, treatment and care [PDF]

, 2007
This research investigated two groups of patients diagnosed with dementia before the age of sixty-five. The patients were diagnosed with Alzheimer's Disease (AD, n = 25) and Frontotemporal Dementia (FTD, n = 37).
Rudge, John
core  

Accuracy of dementia diagnosis - a direct comparison between radiologists and a computerized method [PDF]

, 2008
There has been recent interest in the application of machine learning techniques to neuroimaging-based diagnosis. These methods promise fully automated, standard PC-based clinical decisions, unbiased by variable radiological expertise.
Jack, Clifford R., Jack, C. R., Patel, A.C., Frackowiak, R.S.J., Fox, Nick C., Fox, N.C., Fox, N. C., Mitchell, L. A., Good, C.D., Chen, Frances S., Frackowiak, R. S. J., Mader, I., Chen, F, Mitchell, L.A., Stonnington, C.M., Stonnington, Cynthia M., Patel, A. C., Ashburner, J., Frackowiak, Richard S. J., Barnes, Josephine, Klöppel, Stefan, Chu, C., Roberts, C.C., Mader, Irina, Barnes, J., Good, C. D., Stonnington, C. M., Chu, Carlton, Klöppel, S., Chen, F., Ashburner, John, Roberts, C. C., Jack, C.R.J.   +32 more
core   +1 more source

Genetics of frontotemporal lobar degeneration

Annals of Indian Academy of Neurology, 2010
Frontotemporal lobar degeneration (FTLD) is a highly heterogenous group of progressive neurodegenerative disorders characterized by atrophy of prefrontal and anterior temporal cortices.
Aswathy P, Jairani P, Mathuranath P
doaj  

Exploring Theory of Mind abilities in patients with probable idiopathic normal pressure hydrocephalus

Journal of Neuropsychology, EarlyView.
Abstract This study investigated Theory of Mind (ToM) deficits in patients with suspected idiopathic normal pressure hydrocephalus (iNPH), a condition affecting motor, cognitive and autonomic functions. Given the overlap between ToM‐related neural networks and those affected in iNPH, we examined whether ToM impairments are a feature of the disease ...
Akrivi Vatsi, George Stranjalis, Stylianos Gkatzonis, Christos Koutsarnakis, Eleftherios Neromyliotis, Aristotelis Kalyvas, Ion N. Beratis, Evangelos Drosos, Spyridon Komaitis, Evangelia Liouta   +9 more
wiley   +1 more source

Data‐driven thresholds for standardized classification of severe Alzheimer's disease neuropathology using digital neuropathology

Brain Pathology, Volume 36, Issue 6, November 2026.
We generated digital pathologic algorithms (AI‐based modules that can be freely shared) to: optimize the sampling (ROI) for diagnosis of ADNC‐related tau pathology; compare/transition between Aperio and HALO platforms; and rationalize severe Braak NFT staging, so that all Braak‐VI cases had dementia, and all Braak‐V cases had MCI or dementia.
Ryan K. Shahidehpour, Allison M. Neltner, Mitchell A. Klusty, Cole Corbett, Angelique D. Gonzalez, David A. Gutman, David W. Fardo, Adam D. Bachstetter, Cody Bumgardner, Margaret E. Flanagan, Peter T. Nelson   +10 more
wiley   +1 more source

Is this a new type of primary prosopagnosia, both progressive and apperceptive?

Neuropsychiatric Disease and Treatment, 2012
Azusa Sugimoto1, Shinichi Koyama2, Akira Midorikawa3, Akinori Futamura1, Kiichi Ishiwata4, Kenji Ishii4, Michael W Miller5, Mitsuru Kawamura11Department of Neurology, Showa University School of Medicine, Tokyo, 2Design Psychology Unit, Department of ...
Sugimoto A, Koyama S, Midorikawa A, Futamura A, Ishiwata K, Ishii K, Miller MW, Kawamura M   +7 more
doaj  

Time to diagnosis in FTLD‐associated syndromes in Latin America

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Frontotemporal lobar degeneration (FTLD) often affects younger patients, making time to diagnosis especially consequential. Most evidence comes from high‐income countries, with limited data from Latin America.
Nahuel Magrath‐Guimet, Florentina Morello‐Garcia, Loana De Los Santos, Carolina Ardohain‐Cristalli, Eugenia Tabernero, Hernán Chaves, Pablo Bagnati, Ricardo Francisco Allegri, Joaquin Migeot, Juliana Acosta‐Uribe, Isabel Elaine Allen, David Aguillon, Jose Alberto Avila‐Funes, Maria Isabel Behrens, Martin Bruno, Luis Ignacio Brusco, Nilton Custodio, Elisa de Paula França Resende, Claudia Duran Aniotz, Marilu Gorno‐Tempini, Agustin Ibanez, Kenneth S. Kosik, Marcelo Adrian Maito, Diana Matallana, Bruce Miller, Mike Nalls, Stefanie D. Piña‐Escudero, Kate Possin, Guido Rocatti, Hernando Santamaria‐Garcia, Andrea Slachevsky, Ana Luisa Sosa, Leonel Takada, Jared W. Taylor, Lina M. Zapata‐Restrepo, Jennifer S. Yokoyama, Victor Valcour   +36 more
doaj   +1 more source

Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index, and perivascular space

Brain Pathology, Volume 36, Issue 6, November 2026.
In a mixed diagnostic cohort of pathologically diagnosed Alzheimer's disease, cerebrovascular disease, mixed pathology, and control tissue, we connected the histopathological wasteosome profile in periventricular (PV) brain sections to 7T FLAIR‐MRI confirmed PV white matter hyperintensities (WMHs), vascular stenosis and perivascular space size ...
Nikita Ollen‐Bittle, Isabella Boesgaard, Austyn Roseborough, Meaghan Frank, Qi Zhang, Stephen H. Pasternak, Robert Hammond, Shawn N. Whitehead   +7 more
wiley   +1 more source