Results 61 to 70 of about 23,647 (218)

Structural connectivity in a single case of progressive prosopagnosia: The role of the right inferior longitudinal fasciculus [PDF]

, 2014
Progressive prosopagnosia (PP) is a clinical syndrome characterized by a progressive and selective inability to recognize and identify faces of familiar people. Here we report a patient (G.S.) with PP, mainly related to a prominent deficit in recognition
Alberici, Allison, Allison, Allison, Andrea Soricelli, Angelini, Anna Prinster, Appollonio, Barbarotto, Bartolomeo, Barton, Barton, Behrmann, Benson, Benton, Bodamer, Borroni, Bruce, Caffarra, Caltagirone, Catani, Catani, Catani, Chan, Crawford, Crawford, Damasio, Dario Grossi, De Renzi, De Renzi, Duchaine, Duchaine, Duchaine, Duning, Elena Salvatore, Evans, Farah, Farah, Formisano, Fox, Gainotti, Gainotti, Garrido, Gentileschi, Gentileschi, Grill-Spector, Grossi, Grossi, Grossi, Habib, Haxby, Howard, Huang, Josephs, Joubert, Joubert, Kanwisher, Kawahata, Luigi Trojano, Mario Quarantelli, Marta Ponari, Meadows, Measso, Mesulam, Migliaccio, Migliaccio, Miller, Mori, Neary, Novelli, Omar, Orsini, Paivio, Pitcher, Rajimehr, Riddoch, Rizzo, Rossion, Schmalzl, Sergent, Spinnler, Takahashi, Taylor, Thomas, Trojano, Trojano, Tsao, Tyrrell, van den Brink, Wada, Wetzels, Yamasaki, Yovel   +92 more
core   +1 more source

Biochemical and Immunohistochemical Associations of TDP‐43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer's Disease

Annals of Neurology, EarlyView.
Objective Immunohistochemically (IHC) measured transactive response DNA‐binding protein 43 (TDP‐43) inclusions are observed in Alzheimer's disease (AD) and are associated with medial temporal lobe atrophy. Accumulation of cryptic exons occurs in AD in response to TDP‐43 pathology.
Hossam Youssef, Rodolfo G. Gatto, Nikhil B. Ghayal, Virginia Estades Ayuso, Karen R. Jansen‐West, Judith A. Dunmore, Yuping Song, Mei Yue, Casey N. Cook, Michael DeTure, Bailey D. Rawlinson, Monica Castanedes‐Casey, Clifford R. Jack Jr, Ronald C. Petersen, Dennis W. Dickson, Leonard Petrucelli, Jennifer L. Whitwell, Mercedes Prudencio, Keith A. Josephs   +18 more
wiley   +1 more source

Frontotemporal Lobar Degeneration [PDF]

CNS Drugs, 2010
Frontotemporal lobar degeneration (FTLD) is a clinically and pathologically heterogeneous syndrome, characterized by progressive decline in behaviour or language associated with degeneration of the frontal and anterior temporal lobes. While the seminal cases were described at the turn of the 20th century, FTLD has only recently been appreciated as a ...
Gil D, Rabinovici, Bruce L, Miller
openaire   +2 more sources

The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion‐Tensor‐Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurological disorders affecting older adults, with approximately 7.2 million cases only in the United States. This number is projected to increase to 13.8 million in the United States by 2060, leading to increased expenditures for healthcare, long‐term care and hospice services. Consequently,
Valentina Zecca, Gianmauro Palombelli, Nicola Vanacore, Rossella Canese   +3 more
wiley   +1 more source

Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity

Nature Communications, 2018
TDP-43 is associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTD-TDP). Here, the authors identify the transcriptional elongation factor Ell as a strong modifier of TDP-43-mediated ...
Chia-Yu Chung, Amit Berson, Jason R. Kennerdell, Ashley Sartoris, Travis Unger, Sílvia Porta, Hyung-Jun Kim, Edwin R. Smith, Ali Shilatifard, Vivianna Van Deerlin, Virginia M.-Y. Lee, Alice Chen-Plotkin, Nancy M. Bonini   +12 more
doaj   +1 more source

Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration

Acta Neuropathologica Communications, 2017
An intronic GGGGCC expansion in C9orf72 is the most common known cause of both frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The repeat expansion leads to the generation of sense and antisense repeat RNA aggregates and
Sarah Mizielinska, Charlotte E. Ridler, Rubika Balendra, Annora Thoeng, Nathan S. Woodling, Friedrich A. Grässer, Vincent Plagnol, Tammaryn Lashley, Linda Partridge, Adrian M. Isaacs   +9 more
doaj   +1 more source

Association of cortical and subcortical microstructure with disease severity: impact on cognitive decline and language impairments in frontotemporal lobar degeneration

Alzheimer’s Research & Therapy, 2023
Background Cortical and subcortical microstructural modifications are critical to understanding the pathogenic changes in frontotemporal lobar degeneration (FTLD) subtypes. In this study, we investigated cortical and subcortical microstructure underlying
Wencai Ding, Peng Ren, Liye Yi, Yao Si, Fan Yang, Zhipeng Li, Hongbo Bao, Shi Yan, Xinyu Zhang, Siyang Li, Xia Liang, Lifen Yao, for the Frontotemporal Lobar Degeneration Neuroimaging Initiative   +12 more
doaj   +1 more source

Divergent longitudinal propagation of white matter degradation in logopenic and semantic variants of primary progressive aphasia [PDF]

, 2015
Background: Clinico-pathological distinction of primary progressive aphasia (PPA) can be challenging at clinic presentation. In particular, cross-sectional neuroimaging signatures across the logopenic (lvPPA) and semantic (svPPA) variants are difficult ...
Agosta, Bach, Brambati, Chare, Deramecourt, Fletcher, Galantucci, Gorno-Tempini, Gorno-Tempini, Heim, Hickok, Keihaninejad, Lam, Mackenzie, Mahoney, Mesulam, Mesulam, Mioshi, Mioshi, Nichols, Powers, Rohrer, Rohrer, Saur, Savage, Smith, Smith, Smith, Varentsova, Wicklund, Zhang   +30 more
core   +1 more source

Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers. [PDF]

, 2019
Background and purposeThe objective of this study was to longitudinally investigate the trajectory of change in 1 H MRS measurements in asymptomatic MAPT mutation carriers who became symptomatic during follow-up, and to determine the time at which the ...
Boeve, Bradley F, Boxer, Adam L, Brushaber, Danielle, Chen, Qin, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Graff-Radford, Jonathan, Graff-Radford, Neill, Gunter, Jeffrey L, Haley, Dana, Jones, David, Kantarci, Kejal, Knopman, David, Kraft, Ruth, Lapid, Maria, Lesnick, Timothy, Rademakers, Rosa, Rosen, Howie, Tosakulwong, Nirubol, Wszolek, Zbigniew K   +22 more
core   +3 more sources

Longitudinal Videofluorographic Dysphagia Measures in Progressive Supranuclear Palsy

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Dysphagia can lead to fatal aspiration pneumonia in progressive supranuclear palsy (PSP). Little is known about the longitudinal progression of dysphagia or whether it differs across PSP clinical variants. Objectives To characterize longitudinal changes in dysphagia across PSP variants and determine relationships with disease ...
Anna Chiara Cattani, Jerusha G. Bhaskaran, Farwa Ali, Julie Stierwalt, Federica Agosta, Massimo Filippi, Keith A. Josephs, Heather M. Clark, Jennifer L. Whitwell   +8 more
wiley   +1 more source