Results 41 to 50 of about 14,742 (206)

Biomarkers in frontotemporal lobar degeneration [PDF]

Current Opinion in Neurology, 2010
Recent findings assessing the utility of neuroimaging and biofluid biomarkers are reviewed that help identify patients with frontotemporal lobar degeneration (FTLD) spectrum abnormality.Neuroimaging studies using T1 structural MRI and diffusion tensor imaging (DTI) distinguish between patients with FTLD and Alzheimer's disease, although the reliability
openaire   +2 more sources

Clinical, Genetic and Neuropathological Features of Frontotemporal Dementia: An Update and Guide

Acta Médica Portuguesa, 2013
Introduction: Frontotemporal Lobar Degeneration encompasses a group of heterogeneous disorders with shared behavioural and cognitive symptoms, as well as gross pathological features.
Jorge Pelicano Paulos, João Massano
doaj   +1 more source

Hexanucleotide Repeat Expansion in C9ORF72 Is Not Detected in the Treatment-Resistant Schizophrenia Patients of Chinese Han. [PDF]

PLoS ONE, 2015
Hexanucleotide (GGGGCC) repeat expansion in C9ORF72 (HRE) causes frontotemporal lobar degeneration, frontotemporal dementia-amyotrophic lateral sclerosis, and amyotrophic lateral sclerosis.
Xijia Xu, Shiping Xie, Xiaomeng Shi, Jie Lv, Xiaowei Tang, Xiaolan Wang, Shuiping Lu, Mingzhong Wang, Xiaobing Zhang, Jing Sun, Hui Yao   +10 more
doaj   +1 more source

FOXP2 expression in frontotemporal lobar degeneration-tau [PDF]

, 2020
FOXP2 is altered in a variety of language disorders. We found reduced mRNA and protein expression of FOXP2 in frontal cortex area 8 in Pick's disease, and frontotemporal lobar degeneration-tau linked to P301L mutation presenting with language impairment ...
López González, Irene, Aso Pérez, Ester, Fernandez, Liana, Ferrer, Isidro (Ferrer Abizanda), Carmona Murillo, Margarita, Palmeira, Andre   +5 more
core   +1 more source

Structural Control of Dual Emission in Coumarin Fluorophores for Visualizing Protein Droplet Maturation

Angewandte Chemie, EarlyView.
A coumarin‐based dual‐emission fluorophore was designed to visualize the maturation of protein liquid droplets. Upon covalent conjugation to droplet‐forming proteins, ratiometric fluorescence imaging allowed real time monitoring of droplet maturation. This probe is applicable to the analysis of droplet formation and maturation mechanisms, as well as to
Tomoya Yamamoto, Yusei Otsuka, Asuka Mori, Yuichiro Hori, Yuma Yamamoto, Motonari Uesugi, Kazuya Kikuchi   +6 more
wiley   +2 more sources

Frontotemporal lobar degeneration [PDF]

Archives of Neurology, 2005
Until recently, frontotemporal lobar degeneration (FTLD) was considered a rare neurodegenerative disorder that was difficult to diagnose. The publication of consensus criteria for FTLD, however, prompted systematic studies. The criteria categorize FTLD into 3 subgroups: frontotemporal dementia, semantic dementia, and progressive nonfluent aphasia.To ...
Adam L. Boxer, John Q. Trojanowski, Virginia M.-Y. Lee, Bruce L. Miller   +3 more
openaire   +3 more sources

Mixed neuropathology in frontotemporal lobar degeneration [PDF]

, 2020
Aim: Frontotemporal lobar degeneration (FTLD) is a significant cause of dementia in mid-life and older adults. The extent of interactions between FTLD and other neurodegenerative pathologies is unclear.
Pennington, Catherine; id_orcid, Coulthard, Elizabeth, Love, Seth, Marini, Luca, Pennington, Catherine   +4 more
core   +1 more source

Dissociating memory networks in early Alzheimer's disease and frontotemporal lobar degeneration - a combined study of hypometabolism and atrophy

, 2013
Introduction: We aimed at dissociating the neural correlates of memory disorders in Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD).
Barbara Vogt, Müller, Karsten, Becker, G., Dukart, J., Frisch, Stefan, Osama Sabri, Dukart, Jürgen, Horstmann, A., Schroeter, Matthias, Vogt, B., Sabri, O., Mueller, K. ; https://orcid.org/, Matthias L Schroeter, Barthel, H., Sabri, Osama, Juergen Dukart, Villringer, Arno, Karsten Müller, Villringer, A. ; https://orcid.org/, Henryk Barthel, Vogt, Barbara, Stefan Frisch, Becker, Georg, Frisch, S. ; https://orcid.org/, Annette Horstmann, Arno Villringer, Barthel, Henryk, Schroeter, M. ; https://orcid.org/, Horstmann, Annette, Georg Becker   +29 more
core   +1 more source

Characterization of Movement Disorder Phenomenology in Genetically Proven, Familial Frontotemporal Lobar Degeneration: A Systematic Review and Meta-Analysis.

PLoS ONE, 2016
BackgroundMutations in granulin (PGRN) and tau (MAPT), and hexanucleotide repeat expansions near the C9orf72 genes are the most prevalent genetic causes of frontotemporal lobar degeneration.
Carmen Gasca-Salas, Mario Masellis, Edwin Khoo, Binit B Shah, David Fisman, Anthony E Lang, Galit Kleiner-Fisman   +6 more
doaj   +1 more source

Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis

Communications Biology, 2021
Jin et al use dynamic molecular network analysis to characterise the phosphoproteome in mouse models of neurodegenerative disease. Analyzing four models of frontotemporal lobar degeneration and four models of Alzheimer’s disease, they observe conserved ...
Meihua Jin, Xiaocen Jin, Hidenori Homma, Kyota Fujita, Hikari Tanaka, Shigeo Murayama, Hiroyasu Akatsu, Kazuhiko Tagawa, Hitoshi Okazawa   +8 more
doaj   +1 more source