The structural neuroanatomy of music emotion recognition: evidence from frontotemporal lobar degeneration. [PDF]
Despite growing clinical and neurobiological interest in the brain mechanisms that process emotion in music, these mechanisms remain incompletely understood.
Omar, Rohani +45 more
core +2 more sources
Brainstem : neglected locus in neurodegenerative diseases [PDF]
The most frequent neurodegenerative diseases (NDs) are Alzheimer’s disease (AD), Parkinson’s disease (PD), and frontotemporal lobar degeneration associated with protein TDP-43 (FTLD–TDP).
Lea Tenenholz Grinberg +8 more
core +1 more source
Dementias show differential physiological responses to salient sounds. [PDF]
Abnormal responsiveness to salient sensory signals is often a prominent feature of dementia diseases, particularly the frontotemporal lobar degenerations, but has been little studied. Here we assessed processing of one important class of salient signals,
Nicholas, Jennifer M +43 more
core +1 more source
Metabolomic changes associated with frontotemporal lobar degeneration syndromes. [PDF]
OBJECTIVE: Widespread metabolic changes are seen in neurodegenerative disease and could be used as biomarkers for diagnosis and disease monitoring. They may also reveal disease mechanisms that could be a target for therapy.
core +15 more sources
Neuroanatomical normative modelling in frontotemporal lobar degeneration: higher heterogeneity in the behavioural variant. [PDF]
Data availability: Data used in preparation of this article were obtained from the Frontotemporal Lobar Degeneration Neuroimaging Initiative (FTLDNI) and the 4-Repeat Tauopathy Neuroimaging Initiative (4RTNI) databases (https://4rtni-ftldni.ini.usc.edu/
Konwar S +5 more
europepmc +2 more sources
Combined evaluation of FDG-PET and MRI improves detection and differentiation of dementia. [PDF]
INTRODUCTION: Various biomarkers have been reported in recent literature regarding imaging abnormalities in different types of dementia. These biomarkers have helped to significantly improve early detection and also differentiation of various dementia ...
Möller, Harald E +25 more
core +2 more sources
The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]
Frontotemporal lobar degeneration (FTLD) is the one of the most frequent neurodegenerative disorders characterized by behavioral and executive impairment, language disorders and motor dysfunction.
Holton, Janice L. +27 more
core +1 more source
Introduction Apraxia is common in neurodegenerative dementias but underrepresented in clinical workup for differential diagnoses. Methods Praxis‐profiles were assessed with the Dementia Apraxia Test in 93 patients with early stages of biologically ...
Andreas Johnen +4 more
doaj +1 more source
Voice processing in dementia: a neuropsychological and neuroanatomical analysis. [PDF]
Voice processing in neurodegenerative disease is poorly understood. Here we undertook a systematic investigation of voice processing in a cohort of patients with clinical diagnoses representing two canonical dementia syndromes: temporal variant ...
Julia C. Hailstone +13 more
core +1 more source
A Genome-Wide Screening and SNPs-to-Genes Approach to Identify Novel Genetic Risk Factors Associated with Frontotemporal Dementia [PDF]
Frontotemporal dementia (FTD) is the second most prevalent form of early onset dementia after Alzheimer’s disease (AD). We performed a case-control association study in an Italian FTD cohort (n = 530) followed by the novel SNPs-to-genes approach and ...
Maletta, Raffaele G +121 more
core +1 more source

