Results 21 to 30 of about 23,647 (218)

Rates of lobar atrophy in asymptomatic MAPT mutation carriers. [PDF]

open access: yes, 2019
IntroductionThe aim of this study was to investigate the rates of lobar atrophy in the asymptomatic microtubule-associated protein tau (MAPT) mutation carriers.MethodsMAPT mutation carriers (n = 14; 10 asymptomatic, 4 converters from ...
Boeve, Bradley F   +24 more
core   +2 more sources

New Perspective on Parkinsonism in Frontotemporal Lobar Degeneration [PDF]

open access: yesJournal of Movement Disorders, 2013
Frontotemporal dementia (FTD) is the second most common type of presenile dementia. Three clinical prototypes have been defined; behavioral variant FTD, semantic dementia, and progressive nonfluent aphasia.
Hee Kyung Park, Sun J. Chung
doaj   +1 more source

Pharmacological treatment of frontotemporal lobar degeneration: systematic review Tratamento farmacológico da degeneração lobar frontotemporal: revisão sistemática

open access: yesBrazilian Journal of Psychiatry, 2011
OBJECTIVE: To identify the therapeutic options available for treatment of cognitive and behavioral symptoms in frontotemporal lobar degeneration. METHOD: Systematic review using the descriptors "frontotemporal lobar degeneration" OR "frontotemporal ...
Maria da Glória Portugal   +2 more
doaj   +1 more source

Frontotemporal Lobar Degeneration [PDF]

open access: yesNeurologic Clinics, 2007
Frontotemporal lobar degeneration (FTLD) is a syndromic diagnosis that encompasses at least three different variants. Imaging modalities are clinically useful in FTLD, although pathology remains the gold standard for definitive diagnosis. To date, four different genes have been identified that account for FTLD.
openaire   +2 more sources

Criteria for the diagnosis of corticobasal degeneration [PDF]

open access: yes, 2013
Current criteria for the clinical diagnosis of pathologically confirmed corticobasal degeneration (CBD) no longer reflect the expanding understanding of this disease and its clinicopathologic correlations.
Armstrong, Melissa J   +19 more
core   +1 more source

Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene. [PDF]

open access: yes, 2017
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two apparently distinct neurodegenerative diseases, the former characterized by selective loss of motor neurons in the brain and spinal cord and the latter characterized by ...
Pasinelli, Piera   +3 more
core   +2 more sources

Apraxia profiles—A single cognitive marker to discriminate all variants of frontotemporal lobar degeneration and Alzheimer's disease

open access: yesAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction Apraxia is common in neurodegenerative dementias but underrepresented in clinical workup for differential diagnoses. Methods Praxis‐profiles were assessed with the Dementia Apraxia Test in 93 patients with early stages of biologically ...
Andreas Johnen   +4 more
doaj   +1 more source

Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic Caenorhabditis elegans

open access: yesG3: Genes, Genomes, Genetics, 2021
Amyotrophic lateral sclerosis (ALS) is a debilitating, fatal neurodegenerative disease that causes rapid muscle wasting. It shares a spectrum of symptoms and pathology with frontotemporal lobar degeneration (FTLD).
Aleen D Saxton, Brian C Kraemer
doaj   +1 more source

Dissociation of structural and functional integrities of the motor system in amyotrophic lateral sclerosis and behavioral-variant frontotemporal dementia [PDF]

open access: yes, 2016
Background and Purpose: This study investigated the structural and functional changes in the motor system in amyotrophic lateral sclerosis (ALS; n=25) and behavioral-variant fronto-temporal dementia (bvFTD; n=17) relative to healthy controls (n=37 ...
Bae, Jong Seok   +9 more
core   +2 more sources

Frontotemporal lobar degeneration [PDF]

open access: yesArchives of Neurology, 2005
Until recently, frontotemporal lobar degeneration (FTLD) was considered a rare neurodegenerative disorder that was difficult to diagnose. The publication of consensus criteria for FTLD, however, prompted systematic studies. The criteria categorize FTLD into 3 subgroups: frontotemporal dementia, semantic dementia, and progressive nonfluent aphasia.To ...
Adam L. Boxer   +3 more
openaire   +3 more sources

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