Results 1 to 10 of about 23,647 (218)

HnRNP Pathologies in Frontotemporal Lobar Degeneration

Cells, 2023
Frontotemporal dementia (FTD) is the second most common form of young-onset (
Xinwa Jiang, Ariana Gatt, Tammaryn Lashley   +2 more
doaj   +4 more sources

Individualized Atrophy-Based Prediction of Dementia Progression in Familial Frontotemporal Lobar Degeneration With Bayesian Linear Mixed-Effects Modeling. [PDF]

Ann Neurol
Objective Age of symptom onset is highly variable in familial frontotemporal lobar degeneration (f‐FTLD). Accurate prediction of onset would inform clinical management and trial enrollment. Prior studies indicate that individualized maps of brain atrophy can predict conversion to dementia in f‐FTLD.
Dutt S, Leichter D, Cobigo Y, Wolf A, Kornak J, Clark A, Russell LL, Bouzigues A, Cash DM, Bocchetta M, Olzinski M, Appleby B, Bayram E, Borroni B, Bozoki A, Butler CR, Clark D, Convery RS, Darby RR, de Mendonça A, Dickerson B, Domoto-Reilly K, Ducharme S, Ferry-Bolder E, Finger E, Foster PH, Galasko DR, Galimberti D, Gerhard A, Ghoshal N, Graff C, Graff-Radford N, Grant IM, Hales CM, Honig LS, Hsiung GY, Huey ED, Irwin D, Jiskoot LC, Kremers W, Kwan JY, Laforce R, Le Ber I, Léger GC, Levin J, Litvan I, Mackenzie IR, Masellis M, Mendez MF, Moreno F, Onyike C, Otto M, Pascual B, Pressman P, Rademakers R, Ramos EM, Ritter A, Roberson ED, Rowe JB, Sanchez-Valle R, Santana I, Seelaar H, Snyder A, Sorbi S, Synofzik M, Tartaglia MC, Tiraboschi P, van Swieten JC, Vandebergh M, Vandenberghe R, Heuer HW, Miller BL, Seeley WW, Gorno-Tempini ML, Kramer JH, Forsberg L, Kantarci K, Boeve BF, Boxer AL, Rohrer JD, Rosen HJ, Staffaroni AM, FTD Prevention Initiative (FPI) investigators.   +82 more
europepmc   +2 more sources

Clinical and Imaging Features of Sporadic and Genetic Frontotemporal Lobar Degeneration TDP‐43 A and B [PDF]

Annals of Clinical and Translational Neurology
Objective Certain frontotemporal lobar degeneration subtypes, including TDP‐A and B, can either occur sporadically or in association with specific genetic mutations.
Sean Coulborn, Rhiana Schafer, Ashlin R. K. Roy, Andrzej Sokolowski, Noah G. Cryns, Dana Leichter, Argentina Lario Lago, Eliana Marisa Ramos, Yann Cobigo, Salvatore Spina, Lea T. Grinberg, Daniel H. Geschwind, Maria L. Gorno‐Tempini, Joel H. Kramer, Howard J. Rosen, Bruce L. Miller, William W. Seeley, David C. Perry   +17 more
doaj   +2 more sources

Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease [PDF]

, 2014
Behavioural variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) dementia are characterised by progressive brain atrophy. Longitudinal MRI volumetry may help to characterise ongoing structural degeneration and support the differential ...
AF Fotenos, AT Du, B Dubois, BC Dickerson, Belinda Yew, Bonnie Y. K. Lam, C Bocti, C Davatzikos, C O'Callaghan, CE Krueger, CM Pleizier, D Chan, D Neary, DS Knopman, DS Yi, E Mioshi, E Mioshi, E Ratnavalli, Emma Flanagan, F Agosta, Francisco J. Esteban, G McKhann, H Hampel, Hans-Jürgen Huppertz, HJ Huppertz, HJ Rosen, J Ashburner, JC Looi, JL Whitwell, John R. Hodges, K Rascovsky, K Rascovsky, L Frings, Lars Frings, M Boccardi, M Broe, M Hornberger, M Hornberger, M Hornberger, MA Dalton, Michael Hornberger, Michael Hüll, O Piguet, P Lillo, PJ Nestor, RJ Perry, RR Davies, SM Resnick, TW Chow, WW Seeley, Y Benjamini   +50 more
core   +20 more sources

Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau

Acta Neuropathologica Communications, 2021
Alzheimer’s disease (AD) is associated with inner retina (nerve fiber and ganglion cell layers) thinning. In contrast, we have seen outer retina thinning driven by photoreceptor outer nuclear layer (ONL) thinning with antemortem optical coherence ...
Benjamin J. Kim, Vivian Lee, Edward B. Lee, Adrienne Saludades, John Q. Trojanowski, Joshua L. Dunaief, Murray Grossman, David J. Irwin   +7 more
doaj   +1 more source

MicroRNA biomarkers in frontotemporal dementia and to distinguish from Alzheimer’s disease and amyotrophic lateral sclerosis

Neural Regeneration Research, 2022
Frontotemporal lobar degeneration describes a group of progressive brain disorders that primarily are associated with atrophy of the prefrontal and anterior temporal lobes.
Bridget Martinez, Philip V Peplow
doaj   +1 more source

Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration

Nature Communications, 2023
There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human in vivo and post mortem studies. Understanding the consequences of synaptic loss for network function is important to support translational models ...
David J. Whiteside, Negin Holland, Kamen A. Tsvetanov, Elijah Mak, Maura Malpetti, George Savulich, P. Simon Jones, Michelle Naessens, Matthew A. Rouse, Tim D. Fryer, Young T. Hong, Franklin I. Aigbirhio, Eoin Mulroy, Kailash P. Bhatia, Timothy Rittman, John T. O’Brien, James B. Rowe   +16 more
doaj   +1 more source

The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration

Translational Psychiatry, 2022
There is a pressing need to accelerate therapeutic strategies against the syndromes caused by frontotemporal lobar degeneration, including symptomatic treatments.
Alistair Perry, Laura E. Hughes, Natalie Adams, Michelle Naessens, Alexander G. Murley, Matthew A. Rouse, Duncan Street, P. Simon Jones, Thomas E. Cope, Ece Kocagoncu, James B. Rowe   +10 more
doaj   +1 more source

The role of sequestosome 1/p62 protein in amyotrophic lateral sclerosis and frontotemporal dementia pathogenesis

Neural Regeneration Research, 2020
Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are multifaceted diseases with genotypic, pathological and clinical overlap. One such overlap is the presence of SQSTM1/p62 mutations.
Adriana Delice Foster, Sarah Lyn Rea
doaj   +1 more source

Syndromes associated with frontotemporal lobar degeneration change response patterns on visual analogue scales

Scientific Reports, 2023
Self-report scales are widely used in cognitive neuroscience and psychology. However, they rest on the central assumption that respondents engage meaningfully.
Rebecca S. Williams, Natalie E. Adams, Laura E. Hughes, Matthew A. Rouse, Alexander G. Murley, Michelle Naessens, Duncan Street, Negin Holland, James B. Rowe   +8 more
doaj   +1 more source