Results 1 to 10 of about 5,593 (126)

Regulation of extracellular progranulin in medial prefrontal cortex

Neurobiology of Disease, 2023
Progranulin is a secreted pro-protein that has anti-inflammatory and neurotrophic effects and is necessary for maintaining lysosomal function. Mutations in progranulin (GRN) are a major cause of frontotemporal dementia.
Andrew E Arrant
exaly   +3 more sources

Serum levels of PTEN and progranulin as potential diagnostic and prognostic biomarkers for severe pneumonia in the elderly [PDF]

PeerJ
Background Severe pneumonia presents a critical challenge clinically, especially for elderly patients. This study investigates the diagnostic and prognostic potential of serum Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN) and ...
Yi Ge, Wei Lu, Jinlong Liu, Huan Liang, Linlin Xu   +4 more
doaj   +3 more sources

Genetic frontotemporal degeneration across the lifespan? A critical appraisal of the neurodevelopmental hypothesis. [PDF]

Alzheimers Dement
Abstract Potential neurodevelopmental effects of genetic frontotemporal degeneration (FTD)‐related variants have been postulated by observational studies over the past 25 years. Recent data from large FTD cohort studies have delineated biological and phenotypic characteristics of presymptomatic stages of disease, with some genetic variants showing ...
So I, Birkle TJY, Duff KE, Restrepo-Martinez M, Ducharme S, Finger EC.   +5 more
europepmc   +2 more sources

Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice [PDF]

Neurobiology of Disease
Loss-of-function progranulin (GRN) mutations cause frontotemporal dementia with TDP-43 pathology (FTD-TDP). Nearly all pathogenic GRN mutations cause progranulin haploinsufficiency, but it is unclear how progranulin insufficiency causes FTD-TDP.
Anna K. Cook, Benjamin Lin, Yumo Song, Kelsey M. Greathouse, Azariah K. Kaplelach, Mackenzie L. Love, Skylar E. Davis, Anna C. Stoll, Justin A. Hall, Ahmad R. Hakim, Jakub F. Hel, Giacynta A. Vollmer, Alexandria C. Howard, Noelle H. Cooper, Phaedra N. Manuel, Juliana M. Eberhardt, C. Ryan Miller, Ashley S. Harms, Jeremy H. Herskowitz, Lindsay F. Rizzardi, Andrew E. Arrant   +20 more
doaj   +2 more sources

Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice

Neurobiology of Disease, 2019
Loss-of-function mutations in progranulin (GRN), most of which cause progranulin haploinsufficiency, are a major autosomal dominant cause of frontotemporal dementia (FTD).
Erik D. Roberson, Shreya Kashyap, Andrew E Arrant   +2 more
exaly   +3 more sources

Analysing the effect of full-length and C-terminally truncated progranulin on proliferation, colony formation, and migration in HepG2 and U87 cells [PDF]

Scientific Reports
Progranulin, the precursor protein to seven and a half distinct granulin motifs (GRNs), has been implicated in a broad range of diseases. Progranulin depletion is one of the most frequent causes for hereditary Frontotemporal Dementia (FTD).
Alexander M. Hofer, Luisa Tobler, Marc-David Ruepp, Oliver Mühlemann   +3 more
doaj   +3 more sources

Functional characterization of FAM120A as a novel effector in the progranulin/EphA2 oncogenic axis in bladder cancer [PDF]

Journal of Experimental & Clinical Cancer Research
Background Bladder cancer (BC) is one of the most deadly diseases in the USA, with 84,530 new cases and 17,870 estimated deaths in 2026. The growth factor progranulin is involved in several human pathologies, including frontotemporal dementia (FTD ...
Vrunda Satasiya, Canio Martinelli, Gabriel Pascal, Giacomo Ducci, Elisa Ventura, Stephen J. Williams, Sharon Raffaella Burk, Manuela Nana Tchamou, Shendi Shani, Michele Klain, Elena Sacco, Marco Vanoni, Antonino Belfiore, Renato V. Iozzo, Antonio Giordano, Andrea Morrione   +15 more
doaj   +2 more sources

Synaptic dysfunction in progranulin-deficient mice

Neurobiology of Disease, 2012
Progranulin haploinsufficiency is a common cause of familial frontotemporal dementia (FTD), but the role of progranulin in the brain is poorly understood.
Scott J. Neal, Blair R Leavitt, Lynn A Raymond   +2 more
exaly   +3 more sources

Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia [PDF]

Neurobiology of Disease
Loss-of-function mutations affecting the lysosomal protein progranulin are a leading cause of frontotemporal dementia. Progranulin mutations cause abnormalities in lysosomal lipid processing, particularly of sphingolipids, major components of neural cell
Nicholas R. Boyle, Stephanie N. Fox, Aniketh S. Tadepalli, Nicholas T. Seyfried, Thomas Kukar, Eliana M. Ramos, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant, Erik D. Roberson   +12 more
doaj   +2 more sources

Intrathalamic delivery of adeno-associated viral vector expressing progranulin as gene therapy for GRN-related frontotemporal dementia [PDF]

Molecular Therapy: Methods & Clinical Development
GRN mutations leading to progranulin haploinsufficiency can cause frontotemporal dementia. AVB-101, an investigational gene therapy comprising an adeno-associated virus construct expressing codon-optimized human GRN under a neuronal promoter, was ...
Youn Bok Lee, Do Young Lee, Zoe Walker, Joseph Allison, Aleksandra Kaliszewska, Alinda Fernandes, Katharine Y. Zhang, Yalem Bekele, Paniz Hosseini, Romain Joubert, Joana Furtado, McQuinn Gumus, Olivier Brock, Ali Bienemann, Steven Gill, Samantha Murray, Nadia Mitchell, Page Bouchard, Alex Bloom, John Isaac, Carlos J. Miranda, Christopher E. Shaw   +21 more
doaj   +2 more sources