Progranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several protein disulfide isomerase family proteins. [PDF]
PLoS ONE, 2011 The reduced production or activity of the cysteine-rich glycoprotein progranulin is responsible for about 20% of cases of familial frontotemporal dementia.
Sandra Almeida +2 more
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Progranulin is expressed within motor neurons and promotes neuronal cell survival
BMC Neuroscience, 2009 Background Progranulin is a secreted high molecular weight growth factor bearing seven and one half copies of the cysteine-rich granulin-epithelin motif.
Kay Denis G +11 more
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Adeno‐associated virus serotype 1‐based gene therapy for FTD caused by GRN mutations
Annals of Clinical and Translational Neurology, 2020 Objective Dominant loss‐of‐function mutations in the gene encoding the lysosomal protein, progranulin, cause 5‐10% of frontotemporal dementia cases. As progranulin undergoes secretion and endocytosis, a small number of progranulin‐expressing cells can ...
Christian Hinderer +6 more
doaj +1 more source
Neurobiology of Disease, 2017 Progranulin deficiency due to heterozygous null mutations in the GRN gene is a common cause of familial frontotemporal lobar degeneration (FTLD), while homozygous loss-of-function GRN mutations cause neuronal ceroid lipofuscinosis (NCL). Aged progranulin-
Terri L. Petkau +2 more
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Tumor co-expression of progranulin and sortilin as a prognostic biomarker in breast cancer
BMC Cancer, 2021 Background The growth factor progranulin has been implicated in numerous biological processes such as wound healing, inflammation and progressive tumorigenesis.
Karoline Berger +8 more
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Progranulin serum levels in human kidney transplant recipients: A longitudinal study. [PDF]
PLoS ONE, 2018 The adipokine progranulin has metabolic proprieties, playing a role in obesity and insulin resistance. Its levels seems to be dependent of renal function, since higher progranulin concentration is observed in patients with end-stage kidney disease ...
Bruna Bellincanta Nicoletto +8 more
doaj +1 more source
Patterns of Microglial Cell Activation in Frontotemporal Lobar Degeneration [PDF]
, 2013 AIMS: Pathological heterogeneity within patients with Frontotemporal lobar degeneration (FTLD) in general precludes the accurate assignment of diagnostic subtype in life.
Pickering-Brown, Stuart +10 more
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Progranulin concentration in relation to bone mineral density among obese individuals
Archives of Endocrinology and Metabolism, 2018 Objective Adipose tissue, particularly visceral adipose tissue, secretes a variety of cytokines, among which progranulin is a glycoprotein related to the immune system.
Alireza Milajerdi +4 more
doaj +1 more source
Vorkommen von Progranulin-Autoantikörpern bei Morbus Crohn und Colitis ulcerosa [PDF]
, 2017 Progranulin ist ein Precursor-Glykoprotein, das vornehmlich von epithelialem Gewebe sowie myeloischen und lymphatischen Zellreihen exprimiert wird. Progranulin bindet mit hoher Affinität an die TNF-Rezeptoren 1 und 2 (TNFR1 und 2) und Death receptor 3
Stöger, Elisabeth
core +1 more source
Serum and Urinary Progranulin in Diabetic Kidney Disease. [PDF]
PLoS ONE, 2016 Progranulin has been recognized as an adipokine related to obesity, insulin resistance and type 2 diabetes mellitus (T2DM). There are scarce data regarding progranulin and kidney disease, but there are some data linking diabetic kidney disease (DKD) and ...
Bruna Bellincanta Nicoletto +3 more
doaj +1 more source