Results 31 to 40 of about 11,442 (213)

Progranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several protein disulfide isomerase family proteins. [PDF]

PLoS ONE, 2011
The reduced production or activity of the cysteine-rich glycoprotein progranulin is responsible for about 20% of cases of familial frontotemporal dementia.
Sandra Almeida, Lijuan Zhou, Fen-Biao Gao   +2 more
doaj   +1 more source

Complexity of progranulin mechanisms of action in mesothelioma

Journal of Experimental & Clinical Cancer Research, 2022
Background Mesothelioma is an aggressive disease with limited therapeutic options. The growth factor progranulin plays a critical role in several cancer models, where it regulates tumor initiation and progression.
Elisa Ventura, Christopher Xie, Simone Buraschi, Antonino Belfiore, Renato V. Iozzo, Antonio Giordano, Andrea Morrione   +6 more
doaj   +1 more source

Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals. [PDF]

, 2015
BackgroundClinically significant dysregulation of the insulin-like growth factor (IGF) family proteins occurs in HIV-infected individuals, but the details including whether the deficiencies in IGFs contribute to CNS dysfunction are unknown.MethodsWe ...
Choi, Namjong, Lee, Sunhee C, Letendre, Scott, Lo, Yungtai, Suh, Hyeon-Sook   +4 more
core   +2 more sources

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions [PDF]

, 2014
Hexanucleotide repeat expansions in chromosome 9 open reading frame 72 (C9orf72) have recently been linked to frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis, and may be the most common genetic cause of both neurodegenerative ...
AD Kern, AE Renton, AL Boxer, Albert Llado, Alice S. Chen-Plotkin, Allan Levey, AM Nicholson, Andrew Lieberman, Ann McKee, Anna Antonell, AS Chen-Plotkin, AS Chen-Plotkin, AS Chen-Plotkin, AS Kondrashov, Bernardino Ghetti, BR Brooks, C Cruchaga, Carl Cotman, Carol A. Miller, Carol Dobson-Stone, Catriona McLean, Charles DeCarli, Charles L. White III, Christine Hulette, Christine Van Broeckhoven, Christopher J. McDermott, CM Lang, Danielle Seilhean, David G. Munoz, DM Weinreich, Douglas Galasko, Eliezer Masliah, Ellen Gelpi, EM Wijsman, Eunran Suh, G Skibinski, GD Watts, Glenda Halliday, GM McKhann, H Seelaar, H Stewart, Henry Paulson, I Gijselinck, I Litvan, Ilse Gijselinck, IR Mackenzie, Irina Alafuzoff, J Gass, J Zee van der, J. Robin Highley, Janine Kirby, Jason Warren, JB Toledo, Jean-Jacques Martin, Jill Murrell, Jillian Kril, John B. J. Kwok, John C. Van Swieten, John Hodges, John Q. Trojanowski, Johnathan Cooper-Knock, Jonathan D. Rohrer, Jordan Grafman, Josh Miller, JS Snowden, Julia Kofler, Julie Schneider, Julie van der Zee, K Mori, K Rascovsky, Kimmo J. Hatanpaa, Lauren Elman, Lee-Way Jin, Leo McCluskey, Lisa C. Silbert, M Cruts, M DeJesus-Hernandez, M Hutton, Manuela Neumann, Marc Cruts, Marla Gearing, Martin Rossor, Mary Sano, Matthew P. Frosch, MF Schenk, Michael D. Gallagher, MJ Strong, ML Gorno-Tempini, Murray Grossman, N Finch, Nenad Bogdanovic, Nick Fox, Nigel J. Cairns, OA Brady, Olivier Piguet, P Fratta, Pamela J. Shaw, Patrick Cras, Paul G. Ince, PE Ash, Peter P. De Deyn, Päivi Hartikainen, R Vass, Randall L. Woltjer, Raquel Sanchez-Valle, RF Silva, S Ciura, Safa Al-Sarraj, Salvatore Spina, Sebastiaan Engelborghs, Simon Mead, SS Shankaran, Stephen B. Wharton, SX Xie, Tim Van Langenhove, TP Levine, Virginia M. Y. Lee, Vivianna Van Deerlin, VM Deerlin Van, W Zhang, William Brooks   +120 more
core   +13 more sources

Progranulin is expressed within motor neurons and promotes neuronal cell survival

BMC Neuroscience, 2009
Background Progranulin is a secreted high molecular weight growth factor bearing seven and one half copies of the cysteine-rich granulin-epithelin motif.
Kay Denis G, Minotti Sandra, Durham Heather D, Cao Mingju, Li Zhi, Malik Suneil, Chitramuthu Babykumari P, Baranowski David C, Ryan Cara L, Shaw Christopher A, Bennett Hugh PJ, Bateman Andrew   +11 more
doaj   +1 more source

Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice [PDF]

, 2012
Progranulin haploinsufficiency is associated with frontotemporal dementia in humans. Deficiency of progranulin led to exaggerated inflammation and premature aging in mice.
Albuquerque, Boris, Ding, Aihao, Häussler, Annett, Lim, Hee-Young, Myrczek, Thekla, Tegeder, Irmgard   +5 more
core   +1 more source

EphA2 is a functional receptor for the growth factor progranulin. [PDF]

, 2016
Although the growth factor progranulin was discovered more than two decades ago, the functional receptor remains elusive. Here, we discovered that EphA2, a member of the large family of Ephrin receptor tyrosine kinases, is a functional signaling receptor
Ahmed, Al-Ayadhi, Andrea Morrione, Atul Goyal, Baker, Bateman, Bhandari, Bhandari, Bogan, Brantley, Brantley-Sieders, Brantley-Sieders, Brantley-Sieders, Brantley-Sieders, Buraschi, Carrasquillo, Catherine Sharpe, Cenik, Chan, Chen, Cheng, Cruts, Cruts, Culouscou, Dave, Dunn, Duxbury, Elizabeth Natkanski, Farach-Carson, Ferluga, Gass, Ghidoni, Gijselinck, Giorgio, Goldoni, Gonzalez, Grindel, He, He, Hess, Hu, Huang, Iozzo, Iozzo, Jun, Kessenbrock, Kohlschütter, Kullander, Lema Tomé, Lemmon, Liliana Schaefer, Lord, Lord, Lovat, Margaryan, Matsubara, Merline, Miao, Minami, Misaki, Monami, Monami, Noberini, Nykjaer, Ogawa, Park, Parri, Petty, Prudencio, Renato V. Iozzo, Romanello, Serrero, Simone Buraschi, Sleegers, Smith, Song, Taddei, Tang, Tangkeangsirisin, Tanimoto, Tanimoto, Thomas Neill, Toh, Toh, Tolkatchev, Van Damme, Van Kampen, Wang, Wesa, Whitelock, Wienken, Wilusz, Wykosky, Wykosky, Xia, Xu, Xu, Yamaguchi, Yang, Zanocco-Marani, Zinchuk, Zoeller   +101 more
core   +2 more sources

Modulation of extracellular matrix by nutritional hepatotrophic factors in thioacetamide-induced liver cirrhosis in the rat [PDF]

, 2009
Nutritional substances associated to some hormones enhance liver regeneration when injected intraperitoneally, being denominated hepatotrophic factors (HF).
ALOIA, T.P.A., AVANZO, J.L., BATEMAN, A., DAGLI, M.L.Z., GUERRA, R.R., HERNANDEZ-BLAZQUEZ, F.J., PARRA, O.M., TROTTA, M.R.   +7 more
core   +3 more sources

MicroRNAs in age-related diseases [PDF]

, 2013
Aging is a complex process that is linked to an increased incidence of major diseases such as cardiovascular and neurodegenerative disease, but also cancer and immune disorders.
Jazbutyte V, Olivieri F, Pierluigi Nicotera, Stefanie Dimmeler, Yang J   +4 more
core   +1 more source

Tumor co-expression of progranulin and sortilin as a prognostic biomarker in breast cancer

BMC Cancer, 2021
Background The growth factor progranulin has been implicated in numerous biological processes such as wound healing, inflammation and progressive tumorigenesis.
Karoline Berger, Sara Rhost, Svanheiður Rafnsdóttir, Éamon Hughes, Ylva Magnusson, Maria Ekholm, Olle Stål, Lisa Rydén, Göran Landberg   +8 more
doaj   +1 more source