Results 21 to 30 of about 7,247 (208)
Progranulin in neurodegenerative dementia [PDF]
Journal of Neurochemistry, 2021 AbstractLong‐term or severe lack of protective factors is important in the pathogenesis of neurodegenerative dementia. Progranulin (PGRN), a neurotrophic factor expressed mainly in neurons and microglia, has various neuroprotective effects such as anti‐inflammatory effects, promoting neuron survival and neurite growth, and participating in normal ...
Xiao‐Ming Wang +4 more
openaire +2 more sources
Neurology, 2018 Progranulin is a highly conserved secreted protein that is expressed in multiple cell types, both in the CNS and in peripheral tissues. Both directly and via its conversion to granulins, progranulin regulates cell growth, survival, repair, and inflammation. Progranulin has a major role in regulation of lysosomal function and microglial responses in the
Ryan A, Townley +2 more
openaire +3 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background The mechanisms determining vascular tone are still not completely understood, even though it is a significant factor in blood pressure management. Many circulating proteins have a significant impact on controlling vascular tone.
Ariane Bruder‐Nascimento +5 more
doaj +1 more source
Is Serum Progranulin Level a Biomarker in Autism and Cognitive Development Disorders? [PDF]
, 2022 Objective: Cognitive developmental delay is a picture of the group of early-onset chronic diseases that affect 1.5-10% of children. Autism spectrum disorders are neurodevelopmental diseases with a genetic basis and abnormal brain development ...
Atilla Cayir +17 more
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Can serum progranulin level be used as a prognostic biomarker in non-small cell lung cancer?
Monaldi Archives for Chest Disease, 2022 Progranulin has been considered to be a poor prognostic biomarker for some types of malignancies. However, the clinical significance of serum progranulin level and the prognostic value are still not explored in advanced stages of lung cancer.
Nevin Taci Hoca +4 more
doaj +1 more source
Current Research in Neurobiology, 2023 A growing body of evidence has implicated progranulin in neurodevelopment and indicated that aberrant progranulin expression may be involved in neurodevelopmental disease.
Benjamin Life +4 more
doaj +1 more source
The impact of the progranulin-sortilin axis on breast cancer stem cell activity and patient outcome [PDF]
, 2021 Breast cancer is the most common cancer in women worldwide. Still today, despite current breast cancer therapies, many patients experience treatment resistance and relapse, which are believed to be due to failure in targeting treatment-resistant cancer ...
Berger, Karoline
core +1 more source
Anti-mouse progranulin antibody detects both wild-type progranulin and R493X truncation mutant. [PDF]
, 2023 Immunoblot analysis of progranulin using conditioned medium from HeLa cells transfected with plasmids encoding GFP, wild-type (WT) progranulin, or R493X truncation mutant. mPGRN, mouse progranulin. (PDF)
Frank Rigo (700999) +7 more
core +1 more source
Lysosomal processing of progranulin [PDF]
Molecular Neurodegeneration, 2017 Mutations resulting in progranulin (PGRN) haploinsufficiency cause frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP), a devastating neurodegenerative disease. PGRN is localized to the lysosome and important for proper lysosome function. However, the metabolism of PGRN in the lysosome is still unclear.Here, we report that PGRN
Xiaolai Zhou +5 more
openaire +3 more sources
Heliyon, 2021 Progranulin is an autocrine growth factor that promotes proliferation, migration, invasion, and chemoresistance of various cancer cells. These mechanisms mainly depend on the protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) pathway.
Kuniaki Yabe +7 more
doaj +1 more source