Results 21 to 30 of about 7,909 (155)

Progranulin is an FMRP target that influences macroorchidism but not behaviour in a mouse model of Fragile X Syndrome

Current Research in Neurobiology, 2023
A growing body of evidence has implicated progranulin in neurodevelopment and indicated that aberrant progranulin expression may be involved in neurodevelopmental disease.
Benjamin Life, Luis E.B. Bettio, Ilse Gantois, Brian R. Christie, Blair R. Leavitt   +4 more
doaj   +1 more source

FTD-associated behavioural and transcriptomic abnormalities in ‘humanized’ progranulin-deficient mice: A novel model for progranulin-associated FTD

Neurobiology of Disease, 2023
Frontotemporal dementia (FTD) is an early onset dementia characterized by neuropathology and behavioural changes. A common genetic cause of FTD is haploinsufficiency of the gene progranulin (GRN).
Benjamin Life, Terri L. Petkau, Giuliano N.F. Cruz, Erick I. Navarro-Delgado, Ning Shen, Keegan Korthauer, Blair R. Leavitt   +6 more
doaj   +1 more source

Progranulin protects vascular endothelium against atherosclerotic inflammatory reaction via Akt/eNOS and nuclear factor-κB pathways. [PDF]

PLoS ONE, 2013
OBJECTIVE: Atherosclerosis is considered a chronic inflammatory disease, initiated by activation and dysfunction of the endothelium. Recently, progranulin has been regarded as an important modulator of inflammatory processes; however, the role for ...
Hwan-Jin Hwang, Tae Woo Jung, Ho Cheol Hong, Hae Yoon Choi, Ji-A Seo, Sin Gon Kim, Nan Hee Kim, Kyung Mook Choi, Dong Seop Choi, Sei Hyun Baik, Hye Jin Yoo   +10 more
doaj   +1 more source

Progranulin depletion inhibits proliferation via the transforming growth factor beta/SMAD family member 2 signaling axis in Kasumi-1 cells

Heliyon, 2021
Progranulin is an autocrine growth factor that promotes proliferation, migration, invasion, and chemoresistance of various cancer cells. These mechanisms mainly depend on the protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) pathway.
Kuniaki Yabe, Yasuko Yamamoto, Masao Takemura, Takeshi Hara, Hisashi Tsurumi, Ginette Serrero, Toshitaka Nabeshima, Kuniaki Saito   +7 more
doaj   +1 more source

Progranulin signaling in sepsis, community-acquired bacterial pneumonia and COVID-19: a comparative, observational study

Intensive Care Medicine Experimental, 2021
Background Progranulin is a widely expressed pleiotropic growth factor with a central regulatory effect during the early immune response in sepsis. Progranulin signaling has not been systematically studied and compared between sepsis, community-acquired ...
Florian Brandes, Melanie Borrmann, Dominik Buschmann, Agnes S. Meidert, Marlene Reithmair, Markus Langkamp, Lutz Pridzun, Benedikt Kirchner, Jean-Noël Billaud, Nirav M. Amin, Joseph C. Pearson, Matthias Klein, Daniela Hauer, Clarissa Gevargez Zoubalan, Anja Lindemann, Alexander Choukér, Thomas W. Felbinger, Ortrud K. Steinlein, Michael W. Pfaffl, Ines Kaufmann, Gustav Schelling   +20 more
doaj   +1 more source

Is Serum Progranulin Level a Biomarker in Autism and Cognitive Development Disorders?

, 2022
Objective: Cognitive developmental delay is a picture of the group of early-onset chronic diseases that affect 1.5-10% of children. Autism spectrum disorders are neurodevelopmental diseases with a genetic basis and abnormal brain development ...
Atilla Cayir, Kurt, Nezahat, Ilknur Ibili Ucuz, Kubra Kocak Yilmaz, ÖZGERİŞ, FATMA BETÜL, Onur Burak Dursun, Mevlut Sait Keles, Betül Özgeriş, Fatma, Fatma Betul Ozgeris, Çayir, Atilla, Sait Keleş, Mevlüt, Ibili Ucuz, Ilknur, Burak Dursun, Onur, UCUZ, İLKNUR, Nezahat Kurt, DURSUN, ONUR BURAK, Koçak Yilmaz, Kübra, KELEŞ, MEVLÜT SAİT   +17 more
core   +1 more source

Human progranulin-expressing mice as a novel tool for the development of progranulin-modulating therapeutics

Neurobiology of Disease, 2021
The granulin protein (also known as, and hereafter referred to as, progranulin) is a secreted glycoprotein that contributes to overall brain health. Heterozygous loss-of-function mutations in the gene encoding the progranulin protein (Granulin Precursor,
Terri L. Petkau, Benjamin Life, Ge Lu, Jasmine Yang, Oriol Fornes, Wyeth Wasserman, Elizabeth M. Simpson, Blair R. Leavitt   +7 more
doaj   +1 more source

Learning and memory with neuropathic pain : impact of old age and progranulin deficiency [PDF]

, 2013
Persistent neuropathic pain is a frequent consequence of peripheral nerve injuries, particularly in the elderly. Using the IntelliCage we studied if sciatic nerve injury obstructed learning and memory in young and aged mice, each in wild type and ...
Irmgard eTegeder, Vannoni, Elisabetta, Annett eHäussler, Irmgard Tegeder, Wolfer, David P., Elisabetta Vannoni, David P. Wolfer, Tegeder, Irmgard, Wolfer, David P, Elisabetta eVannoni, Annett Häussler, Häussler, Annett, Boris eAlbuquerque, Boris Albuquerque, Albuquerque, Boris, David P Wolfer, Wolfer, David Paul; id_orcid   +16 more
core   +1 more source

Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice [PDF]

, 2012
Progranulin haploinsufficiency is associated with frontotemporal dementia in humans. Deficiency of progranulin led to exaggerated inflammation and premature aging in mice.
Annett Häussler, Häussler, Annett, Irmgard Tegeder, Lim, Hee-Young, Hee-Young Lim, Aihao Ding, Boris Albuquerque, Albuquerque, Boris, Myrczek, Thekla, Tegeder, Irmgard, Ding, Aihao, Thekla Myrczek   +11 more
core   +1 more source

Anti-mouse progranulin antibody detects both wild-type progranulin and R493X truncation mutant.

, 2023
Immunoblot analysis of progranulin using conditioned medium from HeLa cells transfected with plasmids encoding GFP, wild-type (WT) progranulin, or R493X truncation mutant. mPGRN, mouse progranulin. (PDF)
Frank Rigo (700999), Karen Ling (11034309), Paymaan Jafar-Nejad (440920), Denise M. Smith (14768974), Michael L. Niehoff (9344697), Miles F. Wilkinson (14768977), Susan A. Farr (6580736), Andrew D. Nguyen (9344694)   +7 more
core   +1 more source