Results 41 to 50 of about 11,442 (213)

Progranulin Regulates Inflammation and Tumor

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2020
Progranulin (PGRN) mediates cell cycle progression and cell motility as a pleiotropic growth factor and acts as a universal regulator of cell growth, migration and transformation, cell cycle, wound healing, tumorigenesis, and cytotoxic drug resistance as a secreted glycoprotein.
Chunxiao Liu, Jiayi Li, Wenjing Shi, Liujia Zhang, Shuang Liu, Yingcong Lian, Shujuan Liang, Hongyan Wang   +7 more
openaire   +3 more sources

Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice

Neurobiology of Disease, 2017
Progranulin deficiency due to heterozygous null mutations in the GRN gene is a common cause of familial frontotemporal lobar degeneration (FTLD), while homozygous loss-of-function GRN mutations cause neuronal ceroid lipofuscinosis (NCL). Aged progranulin-
Terri L. Petkau, Jake Blanco, Blair R. Leavitt   +2 more
doaj   +1 more source

Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice [PDF]

eneuro, 2015
AbstractLoss-of-function mutations in progranulin (GRN) are one of the most common genetic causes of frontotemporal dementia (FTD), a progressive, fatal neurodegenerative disorder with no available disease-modifying treatments. Through haploinsufficiency, these mutations reduce levels of progranulin, a protein that has neurotrophic and anti ...
Andrew E. Arrant, Aashka R. Patel, Erik D. Roberson   +2 more
openaire   +2 more sources

Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer disease [PDF]

, 2017
Alzheimer disease (AD), Frontotemporal lobar degeneration (FTD), Amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD) have a certain degree of clinical, pathological and molecular overlap.
Alexandra Medvedeva, Alison Goate, Ben Saef, Carlos Cruchaga, Joanne Norton, John C. Morris, John P. Budde, Jong Hun Kim, Jorge Del-Aguila, Kathleen Black, Laura Ibañez, Maria Victoria Fernández, null null, null null, Oscar Harari, Rachel Chasse, Umber Dube, Yuetiva Deming   +17 more
core   +4 more sources

Progranulin serum levels in human kidney transplant recipients: A longitudinal study. [PDF]

PLoS ONE, 2018
The adipokine progranulin has metabolic proprieties, playing a role in obesity and insulin resistance. Its levels seems to be dependent of renal function, since higher progranulin concentration is observed in patients with end-stage kidney disease ...
Bruna Bellincanta Nicoletto, Elis Forcellini Pedrollo, Larissa Salomoni Carpes, Natália Gomes Coloretti, Thaiana Cirino Krolikowski, Gabriela Corrêa Souza, Luiz Felipe Santos Gonçalves, Roberto Ceratti Manfro, Luis Henrique Canani   +8 more
doaj   +1 more source

Criteria for the diagnosis of corticobasal degeneration [PDF]

, 2013
Current criteria for the clinical diagnosis of pathologically confirmed corticobasal degeneration (CBD) no longer reflect the expanding understanding of this disease and its clinicopathologic correlations.
Armstrong, Melissa J, Bak, Thomas H, Bhatia, Kailash P, Borroni, Barbara, Boxer, Adam L, Dickson, Dennis W, Grossman, Murray, Hallett, Mark, Josephs, Keith A, Kertesz, Andrew, Lang, Anthony E, Lee, Suzee E, Litvan, Irene, Miller, Bruce L, Reich, Stephen G, Riley, David E, Tolosa, Eduardo, Tröster, Alexander I, Vidailhet, Marie, Weiner, William J   +19 more
core   +1 more source

Novel progranulin mutations with reduced serum-progranulin levels in frontotemporal lobar degeneration [PDF]

European Journal of Human Genetics, 2013
Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disease with an age at onset generally below 65 years. Mutations in progranulin (GRN) have been reported to be able to cause FTLD through haploinsufficiency. We have sequenced GRN in 121 patients with FTLD and detected six different mutations in eight patients: p.Gly35Glufs*19,
Huei-Hsin, Chiang, Charlotte, Forsell, Lena, Lilius, Linn, Öijerstedt, Steinunn, Thordardottir, Krishnan, Shanmugarajan, Marie, Westerlund, Inger, Nennesmo, Håkan, Thonberg, Caroline, Graff   +9 more
openaire   +2 more sources

Low plasma progranulin levels in children with autism

Journal of Neuroinflammation, 2011
Background Autoimmunity to brain may play a pathogenic role in autism. In autoimmune disorders, the formation of antigen-antibody complexes triggers an inflammatory response by inducing the infiltration of neutrophils. Local administration of recombinant
Mostafa Gehan A, AL-Ayadhi Laila Y
doaj   +1 more source

Progranulin deficiency exaggerates, whereas progranulin‐derived Atsttrin attenuates, severity of dermatitis in mice [PDF]

FEBS Letters, 2013
PGRN and its derived engineered protein, Atsttrin, were reported to antagonize TNFα and protect against inflammatory arthritis [Tang, W. et al. (2011) The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science 332 (6028) 478–484].
Zhao, Yun-Peng, Tian, Qing-Yun, Liu, Chuan-Ju   +2 more
openaire   +2 more sources

Peripheral Progranulin Levels Do Not Reflect Brain Progranulin Levels

Future Neurology, 2014
EVALUATION OF:  Nicholson AM, Finch NA, Thomas CS et al. Progranulin protein levels are differently regulated in plasma and CSF. Neurology 82(21), 1871–1878 (2014). Nicholson et al. report the first population-based comparative study of progranulin (GRN) levels in plasma and cerebrospinal fluid (CSF) in a large human cohort.
Louis De Muynck, Philip Van Damme
openaire   +1 more source