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Progranulin Regulates Inflammation and Tumor
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2020 Progranulin (PGRN) mediates cell cycle progression and cell motility as a pleiotropic growth factor and acts as a universal regulator of cell growth, migration and transformation, cell cycle, wound healing, tumorigenesis, and cytotoxic drug resistance as a secreted glycoprotein.
Chunxiao Liu +7 more
openaire +3 more sources
Tumor co-expression of progranulin and sortilin as a prognostic biomarker in breast cancer
BMC Cancer, 2021 Background The growth factor progranulin has been implicated in numerous biological processes such as wound healing, inflammation and progressive tumorigenesis.
Karoline Berger +8 more
doaj +1 more source
Neurobiology of Disease, 2017 Progranulin deficiency due to heterozygous null mutations in the GRN gene is a common cause of familial frontotemporal lobar degeneration (FTLD), while homozygous loss-of-function GRN mutations cause neuronal ceroid lipofuscinosis (NCL). Aged progranulin-
Terri L. Petkau +2 more
doaj +1 more source
Novel progranulin mutations with reduced serum-progranulin levels in frontotemporal lobar degeneration [PDF]
European Journal of Human Genetics, 2013 Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disease with an age at onset generally below 65 years. Mutations in progranulin (GRN) have been reported to be able to cause FTLD through haploinsufficiency. We have sequenced GRN in 121 patients with FTLD and detected six different mutations in eight patients: p.Gly35Glufs*19,
Huei-Hsin, Chiang +9 more
openaire +2 more sources
Progranulin serum levels in human kidney transplant recipients: A longitudinal study. [PDF]
PLoS ONE, 2018 The adipokine progranulin has metabolic proprieties, playing a role in obesity and insulin resistance. Its levels seems to be dependent of renal function, since higher progranulin concentration is observed in patients with end-stage kidney disease ...
Bruna Bellincanta Nicoletto +8 more
doaj +1 more source
Progranulin, lysosomal regulation and neurodegenerative disease [PDF]
, 2017 The discovery that heterozygous and homozygous mutations in the gene encoding progranulin are causally linked to frontotemporal dementia and lysosomal storage disease, respectively, reveals previously unrecognized roles of the progranulin protein in ...
Andrew McKay +9 more
core +1 more source
Vorkommen von Progranulin-Autoantikörpern bei Morbus Crohn und Colitis ulcerosa [PDF]
, 2017 Progranulin ist ein Precursor-Glykoprotein, das vornehmlich von epithelialem Gewebe sowie myeloischen und lymphatischen Zellreihen exprimiert wird. Progranulin bindet mit hoher Affinität an die TNF-Rezeptoren 1 und 2 (TNFR1 und 2) und Death receptor 3
Stöger, Elisabeth
core +1 more source
Progranulin concentration in relation to bone mineral density among obese individuals
Archives of Endocrinology and Metabolism, 2018 Objective Adipose tissue, particularly visceral adipose tissue, secretes a variety of cytokines, among which progranulin is a glycoprotein related to the immune system.
Alireza Milajerdi +4 more
doaj +1 more source
Serum and Urinary Progranulin in Diabetic Kidney Disease. [PDF]
PLoS ONE, 2016 Progranulin has been recognized as an adipokine related to obesity, insulin resistance and type 2 diabetes mellitus (T2DM). There are scarce data regarding progranulin and kidney disease, but there are some data linking diabetic kidney disease (DKD) and ...
Bruna Bellincanta Nicoletto +3 more
doaj +1 more source
Analysis of Progranulin-Mediated Akt and MAPK Activation [PDF]
, 2018 Progranulin has emerged in recent years as an important regulator of various biological functions including cell proliferation, wound healing, motility, and protection from apoptosis.
Renato V. Iozzo +13 more
core +1 more source