Results 41 to 50 of about 7,909 (155)
Outcomes of progranulin gene therapy in the retina are dependent on time and route of delivery
Molecular Therapy: Methods & Clinical Development, 2021 Neuronal ceroid lipofuscinosis (NCL) is a family of neurodegenerative diseases caused by mutations to genes related to lysosomal function. One variant, CNL11, is caused by mutations to the gene encoding the protein progranulin, which regulates neuronal ...
Emilia A. Zin +6 more
doaj +1 more source
Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies
MedComm, Volume 7, Issue 10, October 2026.The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao +7 more
wiley +1 more source
Progranulin, lysosomal regulation and neurodegenerative disease [PDF]
, 2017 The discovery that heterozygous and homozygous mutations in the gene encoding progranulin are causally linked to frontotemporal dementia and lysosomal storage disease, respectively, reveals previously unrecognized roles of the progranulin protein in ...
Andrew McKay +9 more
core +1 more source
EphA2 is a functional receptor for the growth factor progranulin. [PDF]
, 2016 Although the growth factor progranulin was discovered more than two decades ago, the functional receptor remains elusive. Here, we discovered that EphA2, a member of the large family of Ephrin receptor tyrosine kinases, is a functional signaling receptor
Neill, Thomas +17 more
core +2 more sources
Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.Abstract INTRODUCTION Intrinsic functional connectivity network abnormalities in C9orf72 hexanucleotide repeat expansion carriers emerge during the asymptomatic phase, yet longitudinal studies remain limited. We examined cross‐sectional abnormalities and longitudinal connectivity changes across clinical stages.
Liwen Zhang +23 more
wiley +1 more source
Immunity, Inflammation and Disease, 2019 Objective The present study aimed to investigate progranulin autoantibodies in systemic sclerosis and autoimmune connective tissue disorders. Progranulin is a physiologic tumor necrosis factor (TNF) antagonist. Progranulin antibodies decrease progranulin
Philipp Klemm +7 more
doaj +1 more source
American Journal of Reproductive Immunology, Volume 96, Issue 3, September 2026.ABSTRACT Problem Tokishakuyakusan (TSS) is a traditional Japanese Kampo medicine widely used to support pregnancy; however, its molecular mechanisms remain poorly understood. This study aimed to elucidate the progesterone‐related immunomodulatory mechanisms underlying the pregnancy‐supportive effects of TSS using a mouse model of progesterone ...
Takeshi Nagamatsu +8 more
wiley +1 more source
The Role of Progranulin in Frontotemporal Dementia
, 2023 Frontotemporal dementia (FTD) is one of the most common forms of presenile dementia with a cost per patient per year greater than Alzheimer's disease.
Werthmann, Gordon Chandler
core +1 more source
Acta Neuropathologica Communications, 2019 Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotemporal dementia. Most pathogenic GRN mutations result in progranulin haploinsufficiency, which is thought to cause frontotemporal dementia in GRN mutation ...
Andrew E. Arrant +12 more
doaj +1 more source
Journal of Neuroinflammation, 2017 Background Progranulin deficiency due to heterozygous null mutations in the GRN gene are a common cause of familial frontotemporal lobar degeneration (FTLD), while homozygous loss-of-function GRN mutations are thought to be a rare cause of neuronal ...
Terri L. Petkau +4 more
doaj +1 more source