Results 61 to 70 of about 7,247 (208)

Biochemical and Immunohistochemical Associations of TDP‐43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer's Disease

Annals of Neurology, Volume 100, Issue 1, Page 193-205, July 2026.
Objective Immunohistochemically (IHC) measured transactive response DNA‐binding protein 43 (TDP‐43) inclusions are observed in Alzheimer's disease (AD) and are associated with medial temporal lobe atrophy. Accumulation of cryptic exons occurs in AD in response to TDP‐43 pathology.
Hossam Youssef, Rodolfo G. Gatto, Nikhil B. Ghayal, Virginia Estades Ayuso, Karen R. Jansen‐West, Judith A. Dunmore, Yuping Song, Mei Yue, Casey N. Cook, Michael DeTure, Bailey D. Rawlinson, Monica Castanedes‐Casey, Clifford R. Jack Jr, Ronald C. Petersen, Dennis W. Dickson, Leonard Petrucelli, Jennifer L. Whitwell, Mercedes Prudencio, Keith A. Josephs   +18 more
wiley   +1 more source

Peripheral Progranulin Levels Do Not Reflect Brain Progranulin Levels

Future Neurology, 2014
EVALUATION OF:  Nicholson AM, Finch NA, Thomas CS et al. Progranulin protein levels are differently regulated in plasma and CSF. Neurology 82(21), 1871–1878 (2014). Nicholson et al. report the first population-based comparative study of progranulin (GRN) levels in plasma and cerebrospinal fluid (CSF) in a large human cohort.
Louis De Muynck, Philip Van Damme
openaire   +1 more source

Progranulin deficiency exaggerates, whereas progranulin‐derived Atsttrin attenuates, severity of dermatitis in mice [PDF]

FEBS Letters, 2013
PGRN and its derived engineered protein, Atsttrin, were reported to antagonize TNFα and protect against inflammatory arthritis [Tang, W. et al. (2011) The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science 332 (6028) 478–484].
Zhao, Yun-Peng, Tian, Qing-Yun, Liu, Chuan-Ju   +2 more
openaire   +2 more sources

Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations

Acta Neuropathologica Communications, 2019
Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotemporal dementia. Most pathogenic GRN mutations result in progranulin haploinsufficiency, which is thought to cause frontotemporal dementia in GRN mutation ...
Andrew E. Arrant, Jonathan R. Roth, Nicholas R. Boyle, Shreya N. Kashyap, Madelyn Q. Hoffmann, Charles F. Murchison, Eliana Marisa Ramos, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Erik D. Roberson   +12 more
doaj   +1 more source

Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation

Journal of Neuroinflammation, 2017
Background Progranulin deficiency due to heterozygous null mutations in the GRN gene are a common cause of familial frontotemporal lobar degeneration (FTLD), while homozygous loss-of-function GRN mutations are thought to be a rare cause of neuronal ...
Terri L. Petkau, Natalia Kosior, Kathleen de Asis, Colúm Connolly, Blair R. Leavitt   +4 more
doaj   +1 more source

Plasma Proteomic Changes in GRN and C9orf72 Frontotemporal Dementia

European Journal of Neurology, Volume 33, Issue 7, July 2026.
Multiplex plasma profiling of 124 CNS‐related proteins in genetic frontotemporal dementia (FTD) identified NfL and NfH as the most consistently altered biomarkers in both GRN‐ and C9orf72‐associated disease. Distinct protein changes emerged across genotypes, including changes in GFAP and VCAM1 in GRN‐FTD, and reduced NPTXR as well as nominally altered ...
Joel Simrén, Andrea L. Benedet, Guglielmo Di Molfetta, Ilaria Pola, Kübra Tan, Valentina Cantoni, Ilenia Libri, Jasmine Rivolta, Roberta Ghidoni, Henrik Zetterberg, Barbara Borroni, Nicholas J. Ashton   +11 more
wiley   +1 more source

Progranulin: Functions and neurologic correlations [PDF]

Neurology, 2018
In the Clinical Implications of Neuroscience Research article “Progranulin: Functions and …
openaire   +3 more sources

The zebrafish progranulin gene family / [PDF]

, 2003
Granulins are small cysteine-rich peptide growth factors that, in mammals, are derived from a common glycoprotein precursor (progranulin) containing one half and seven non-identical tandemly repeated granulin domains.
Cadieux, Benoît
core  

Supplementary Material for: Cerebrospinal Fluid Progranulin, but Not Serum Progranulin, Is Reduced in GRN-Negative Frontotemporal Dementia [PDF]

, 2016
Background and Objective: Reduced progranulin levels are a hallmark of frontotemporal dementia (FTD) caused by loss-of-function (LoF) mutations in the progranulin gene (GRN).
Deuschle C. (3226044), Blauwendraat C. (3226038), Maetzler W. (3226059), Wilke C. (3226062), Metzger F.G. (3226041), Jansen I.E. (3226047), Synofzik M. (3226056), Hobert M.A. (3226065), Gillardon F. (3226053), Gasser T. (3226068), Heutink P. (3226050)   +10 more
core   +1 more source

Serum progranulin level is associated with disease activity following orthopedic surgery in rheumatoid arthritis patients

Journal of International Medical Research, 2020
Background Few studies have focused on the ability of progranulin to predict postoperative disease activity in rheumatoid arthritis (RA) patients who have undergone surgery. This study evaluated serum progranulin levels in active RA patients and analyzed
Chunyu Kong, Yuquan Shi, Junhua Xu, Zijuan Xiu, Wufang Qi   +4 more
doaj   +1 more source