Results 61 to 70 of about 7,909 (155)

Co‐ and Multi‐Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review

Movement Disorders, Volume 41, Issue 8, Page 1979-1992, August 2026.
Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo, Per Borghammer, Inas Elsayed, Jennifer G. Goldman, Yue Huang, Katja Lohmann, Per Svenningsson, Lorraine V. Kalia, Daniela Berg, Jeffrey H. Kordower, the MDS Scientific Issues Committee   +10 more
wiley   +1 more source

Relationships of CSF biomarkers to cortical atrophy in early‐onset Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Although cerebrospinal fluid (CSF) biomarkers reflect neurodegeneration in Alzheimer's disease (AD), it remains unclear whether these biomarkers track neurodegeneration in early‐onset Alzheimer's disease (EOAD). METHODS In 80 EOAD patients, we examined correlations between eight CSF biomarker levels and cortical thickness ...
Alexandra Touroutoglou, Yuta Katsumi, Jennifer Hensel, Suzanne E. Schindler, Laura Ibanez, Michael Brickhouse, Ani Eloyan, Ryan Eckbo, Alexander Zaitsev, Renaud La Joie, Maryanne Thangarajah, Alexander Taurone, Prashanthi Vemuri, Clifford R. Jack Jr., Dustin B. Hammers, Tatiana Foroud, Paul Aisen, Laurel Beckett, Robert Koeppe, Walter A. Kukull, Arthur Toga, Alireza Atri, David Clark, Gregory S. Day, Ranjan Duara, Neill R. Graff‐Radford, Ian M. Grant, Lawrence S. Honig, Erik C. B. Johnson, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon Sha, R. Scott Turner, Thomas S. Wingo, David A. Wolk, Kyle Womack, Maria C. Carrillo, Gil D. Rabinovici, Liana G. Apostolova, Jeffrey L. Dage, Bradford C. Dickerson, Mark C. Eldaief, the LEADS Consortium   +48 more
wiley   +1 more source

Sortilin Regulates Progranulin Action in Castration-Resistant Prostate Cancer Cells [PDF]

, 2016
The growth factor progranulin is as an important regulator of transformation in several cellular systems. We have previously demonstrated that progranulin acts as an autocrine growth factor and stimulates motility, proliferation, and anchorage ...
Morcavallo, Alaide, Gomella, Leonard G., Lu, Kuojung G., Stefanello, Manuela, Scotlandi, Katia, Belfiore, Antonino, Bagley, Demetrius H., Iozzo, Renato V., Tanimoto, Ryuta, Buraschi, Simone, Morrione, Andrea, Terracciano, Mario, Xi, Shi-Qiong, Morrione|   +13 more
core   +1 more source

Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neurodegenerative pathologies

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION The impact of different neuropathologies on deep brain structures remains to be understood. We examine subcortical and limbic volumetry in neurodegenerative diseases involving phosphorylated tau (p‐tau), α‐synuclein, and transactive response DNA binding protein 43 (TDP‐43).
Pulkit Khandelwal, Michael Tran Duong, Lisa M. Levorse, Winifred Trotman, Alejandra Bahena, Sydney A. Lim, Amanda E. Denning, Eunice Chung, Christopher A. Olm, Hamsanandini Radhakrishnan, Ranjit Ittyerah, Karthik Prabhakaran, Gabor Mizsei, Theresa Schuck, Sheina Emrani, Joaquin A. Vizcarra, John Robinson, Daniel T. Ohm, Jeffrey S. Phillips, Jesse Cohen, Laura E. M. Wisse, John A. Detre, Ilya M. Nasrallah, Christopher A. Brown, Sandhitsu R. Das, Edward B. Lee, M. Dylan Tisdall, David J. Irwin, Corey T. McMillan, David A. Wolk, Paul A. Yushkevich   +30 more
wiley   +1 more source

Biochemical and Immunohistochemical Associations of TDP‐43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer's Disease

Annals of Neurology, Volume 100, Issue 1, Page 193-205, July 2026.
Objective Immunohistochemically (IHC) measured transactive response DNA‐binding protein 43 (TDP‐43) inclusions are observed in Alzheimer's disease (AD) and are associated with medial temporal lobe atrophy. Accumulation of cryptic exons occurs in AD in response to TDP‐43 pathology.
Hossam Youssef, Rodolfo G. Gatto, Nikhil B. Ghayal, Virginia Estades Ayuso, Karen R. Jansen‐West, Judith A. Dunmore, Yuping Song, Mei Yue, Casey N. Cook, Michael DeTure, Bailey D. Rawlinson, Monica Castanedes‐Casey, Clifford R. Jack Jr, Ronald C. Petersen, Dennis W. Dickson, Leonard Petrucelli, Jennifer L. Whitwell, Mercedes Prudencio, Keith A. Josephs   +18 more
wiley   +1 more source

Expression of the growth factor progranulin in endothelial cells influences growth and development of blood vessels: a novel mouse model. [PDF]

PLoS ONE, 2013
Progranulin is a secreted glycoprotein that regulates cell proliferation, migration and survival. It has roles in development, tumorigenesis, wound healing, neurodegeneration and inflammation.
Huishi Toh, Mingju Cao, Eugene Daniels, Andrew Bateman   +3 more
doaj   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, Volume 293, Issue 13, Page 3788-3813, July 2026.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

The role of progranulin in the brain

, 2014
Frontotemporal lobar degeneration (FTLD) is a devastating, late-onset neurodegenerative disorder that causes profound behavioral abnormalities, language impairment, and alterations in personality in affected patients.
Petkau, Terri Lynn
core   +1 more source

The Evolution of the Secreted Regulatory Protein Progranulin. [PDF]

PLoS ONE, 2015
Progranulin is a secreted growth factor that is active in tumorigenesis, wound repair, and inflammation. Haploinsufficiency of the human progranulin gene, GRN, causes frontotemporal dementia.
Roger G E Palfree, Hugh P J Bennett, Andrew Bateman   +2 more
doaj   +1 more source

Neural Organoid Models as a Platform for Studying Disease Mechanisms in Amyotrophic Lateral Sclerosis

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Amyotrophic lateral sclerosis (ALS) involves widespread cortical pathology beyond the motor cortex. Human‐induced pluripotent stem cell‐derived neural organoids model cortical tissue in vitro and provide a physiologically relevant platform to study disease mechanisms in ALS.
Kristel N. Eigenhuis, Roberto Montoro Ferrer, R. Jeroen Pasterkamp   +2 more
wiley   +1 more source