Results 61 to 70 of about 11,442 (213)

Association of Progranulin Gene Expression from Dyspeptic Patients with Virulent Helicobacter pylori Strains; In Vivo Model

Microorganisms, 2022
(1) Background: Gastric cancer, the fourth most common cause of death from tumors in the world, is closely associated with Helicobacter pylori. Timely diagnosis, therefore, is essential to achieve a higher survival rate.
Claudia Troncoso, Mónica Pavez, Álvaro Cerda, Victor Manríquez, Aurora Prado, Edmundo Hofmann, Eddy Ríos, Armando Sierralta, Luis Copelli, Leticia Barrientos   +9 more
doaj   +1 more source

Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients [PDF]

, 2011
The progranulin gene (PGRN) encodes a pleiotropic molecule with anti-inflammatory actions and neuronal protective effects. Accordingly, PGRN-deficient mice have been demonstrated to develop enhanced inflammation and progressive neurodegeneration. Loss of
Paola Bossù, Francesca Salani, Antonella Alberici, Silvana Archetti, Giuseppe Bellelli, Daniela Galimberti, Elio Scarpini, Gianfranco Spalletta, Carlo Caltagirone, Alessandro Padovani, Barbara Borroni   +10 more
core   +1 more source

Exploring pathways leading to drug‐resistant epilepsy for patients with cryptogenic new onset refractory status epilepticus

Epilepsia, EarlyView.
Abstract Objective Cryptogenic new onset refractory status epilepticus (cNORSE) carries high risks of long‐term disability and post‐NORSE epilepsy, but mechanisms remain unclear. We aimed to assess the predictive value of inflammatory and brain injury biomarkers and determine whether immune disturbances persist in the chronic phase. Methods We enrolled
Aurélie Hanin, Clémence Marois, Martin Guillemaud, Mario Chavez, Léa Cosme, Zineb Hayatou, Aurore Besnard, Gwen Goudard, Véronique Masson, Louis Cousyn, Margaux Cheval, Jérôme A. Denis, Rana Alkouri, Foudil Lamari, Francesca Bisulli, Krista Eschbach, Raquel Farias‐Moeller, Nicolas Gaspard, Elizabeth E. Gerard, Giada Giovannini, Teneille Gofton, Margaret T. Gopaul, Marissa Kellogg, Stefano Meletti, Lorenzo Muccioli, Elena Pasini, Olga Taraschenko, Nathan Torcida, Mark S. Wainwright, Ji Yeoun Yoo, Nora Wong, Dominique Bonnefont‐Rousselot, Sophie Demeret, Lawrence J. Hirsch, Vincent Navarro   +34 more
wiley   +1 more source

Association Between Progranulin and Gaucher Disease [PDF]

EBioMedicine, 2016
Gaucher disease (GD) is a genetic disease caused by mutations in the GBA1 gene which result in reduced enzymatic activity of β-glucocerebrosidase (GCase). This study identified the progranulin (PGRN) gene (GRN) as another gene associated with GD.Serum levels of PGRN were measured from 115 GD patients and 99 healthy controls, whole GRN gene from 40 GD ...
Jian, J., Zhao, S., Tian, Q.-Y., Liu, H., Zhao, Y., Chen, W.-C., Grunig, G., Torres, P.A., Wang, B.C., Zeng, B., Pastores, G., Tang, W., Sun, Y., Grabowski, G.A., Kong, M.X., Wang, G., Chen, Y., Liang, F., Overkleeft, H.S., Saunders-Pullman, R., Chan, G.L., Liu, C.-J.   +21 more
openaire   +5 more sources

Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation

Journal of Neuroinflammation, 2017
Background Progranulin deficiency due to heterozygous null mutations in the GRN gene are a common cause of familial frontotemporal lobar degeneration (FTLD), while homozygous loss-of-function GRN mutations are thought to be a rare cause of neuronal ...
Terri L. Petkau, Natalia Kosior, Kathleen de Asis, Colúm Connolly, Blair R. Leavitt   +4 more
doaj   +1 more source

The effect of non‐surgical periodontal treatment on progranulin levels

Journal of Periodontology, EarlyView.
Abstract Background The aim of this study was to study the effect of non‐surgical periodontal therapy (NSPT) on gingival crevicular fluid (GCF) and serum progranulin (PGRN) levels in the early healing phases. Methods The study included periodontitis (test) (n = 24) and periodontal health (control) (n = 24) groups.
Aysegul Sari, Pasquale Santamaria, Luigi Nibali   +2 more
wiley   +1 more source

Transcriptome-pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS. [PDF]

, 2018
Sporadic amyotrophic lateral sclerosis (sALS) is the most common form of ALS, however, the molecular mechanisms underlying cellular damage and motor neuron degeneration remain elusive.
Batra, Ranjan, Baughn, Michael W, Diaz-Garcia, Sandra, Hutt, Kasey, Kohl, Zacharias, Krach, Florian, Libby, Ryan T, Madrigal, Assael A, Pirie, Elaine, Rabin, Stuart J, Ravits, John, Rodriguez, Maria, Saberi, Shahram, Stauffer, Jennifer, Vu, Anthony Q, Wang, Ruth, Wheeler, Emily C, Winner, Beate, Yeo, Gene W   +18 more
core   +1 more source

Next‐Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS

Cell Proliferation, EarlyView.
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang, Jinrui Li, Xingjia Mao, Wanyu Wang, Yansong Li, Xuefei Hu, Jinjie Zhong, Fengdong Zhao, Linlin Wang   +8 more
wiley   +1 more source

Moxibustion upregulates hippocampal progranulin expression

Neural Regeneration Research, 2016
In China, moxibustion is reported to be useful and has few side effects for chronic fatigue syndrome, but its mechanisms are largely unknown. More recently, the focus has been on the wealth of information supporting stress as a factor in chronic fatigue syndrome, and largely concerns dysregulation in the stress-related hypothalamic-pituitary-adrenal ...
Tao Yi, Li Qi, Ji Li, Jing-jing Le, Lei Shao, Xin Du, Jing-cheng Dong   +6 more
openaire   +3 more sources

rs5848 polymorphism and serum progranulin level [PDF]

Journal of the Neurological Sciences, 2011
To assess the influence of rs5848 polymorphism in serum progranulin (PGRN) level in a cohort of subjects with Alzheimer and related dementias from a tertiary referral clinic.Mutations in the GRN gene cause autosomal dominant frontotemporal dementia (FTD) with TDP-43 pathology (FTLD-TDP) through haploinsufficiency.
Ging-Yuek R, Hsiung, Alice, Fok, Howard H, Feldman, Rosa, Rademakers, Ian R A, Mackenzie   +4 more
openaire   +2 more sources