Results 81 to 90 of about 7,247 (208)
A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology
JOR SPINE, Volume 9, Issue 2, June 2026.A literature‐based signaling network capturing the most relevant pathways in human nucleus pulposus cells was first constructed from curated biological evidence. The network was then translated into a system of ordinary differential equations to derive steady‐state solutions and define median baseline activity levels.
Sofia Tseranidou +11 more
wiley +1 more source
Cellular Localization of Gene Expression for Progranulin [PDF]
Journal of Histochemistry & Cytochemistry, 2000 Granulins, also called epithelins, are 6-kD peptides with growth modulatory effects on a variety of cells. The granulin/epithelin precursor supports tumorigenesis in appropriate cell models and is the only growth factor able to overcome the cell cycle block that occurs in murine fibroblasts after deletion of a functional IGF-1 receptor. However, little
R, Daniel +4 more
openaire +2 more sources
Patterns of Microglial Cell Activation in Frontotemporal Lobar Degeneration [PDF]
, 2013 AIMS: Pathological heterogeneity within patients with Frontotemporal lobar degeneration (FTLD) in general precludes the accurate assignment of diagnostic subtype in life.
Pickering-Brown, Stuart +10 more
core +1 more source
Cell Proliferation, Volume 59, Issue 6, June 2026.Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang +8 more
wiley +1 more source
Progranulin and its biological effects in cancer [PDF]
Medical Oncology, 2017 Cancer cells have defects in regulatory mechanisms that usually control cell proliferation and homeostasis. Different cancer cells share crucial alterations in cell physiology, which lead to malignant growth. Tumorigenesis or tumor growth requires a series of events that include constant cell proliferation, promotion of metastasis and invasion ...
Fabian Arechavaleta-Velasco +3 more
openaire +2 more sources
Progranulin: An emerging target for FTLD therapies [PDF]
Brain Research, 2012 Frontotemporal lobar degeneration (FTLD), a neurodegenerative disease primarily affecting the frontal and temporal lobes, is one of the most common types of dementia. While the majority of FTLD cases are sporadic, approximately 10-40% of patients have an inherited form of FTLD.
Jennifer, Gass +3 more
openaire +2 more sources
A novel oncogenic protein in the Progranulin\EphA2 axis: the role of Myoferlin in bladder cancer [PDF]
, 2022 reservedThe growth factor progranulin plays a key role in bladder cancer by promoting cell motility and invasion. Until recently, the progranulin signaling receptor remained unknown precluding a full comprehension of progranulin action in cancer.
RUGGIERO, VALENTINA
core
Expression of the growth factor progranulin in endothelial cells influences growth and development of blood vessels: a novel mouse model. [PDF]
PLoS ONE, 2013 Progranulin is a secreted glycoprotein that regulates cell proliferation, migration and survival. It has roles in development, tumorigenesis, wound healing, neurodegeneration and inflammation.
Huishi Toh +3 more
doaj +1 more source
Progranulin Biology: Small Molecule Enhancers of Progranulin Expression and Biochemical Analysis of Granulin Receptors [PDF]
, 2015 Frontotemporal dementia (FTD) is the second most common presenile dementia syndrome. Mutations in the GRN gene account for about 20% of patients with familial FTD.
Cenik, Basar 1981-
core
Progranulin as a biomarker and potential therapeutic agent [PDF]
, 2019 Progranulin is a cysteine-rich secreted protein with diverse pleiotropic actions and participates in several processes, such as inflammation or tumorigenesis.
Scotece, M +9 more
core +2 more sources