Results 81 to 90 of about 11,442 (213)
A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology
JOR SPINE, Volume 9, Issue 2, June 2026.A literature‐based signaling network capturing the most relevant pathways in human nucleus pulposus cells was first constructed from curated biological evidence. The network was then translated into a system of ordinary differential equations to derive steady‐state solutions and define median baseline activity levels.
Sofia Tseranidou +11 more
wiley +1 more source
Copy number gain of granulin-epithelin precursor (GEP) at chromosome 17q21 associates with overexpression in human liver cancer [PDF]
, 2015 BACKGROUND: Granulin-epithelin precursor (GEP), a secretory growth factor, demonstrated overexpression in various human cancers, however, mechanism remain elusive.
Carol YK Tong +10 more
core +4 more sources
Advanced Science, Volume 13, Issue 19, 2 April 2026.This review charts the evolution of corneal hydrogels from passive replacements to active and intelligent systems, evaluating natural and synthetic materials while addressing design challenges such as transparency and strength. Advanced applications such as scarless wound healing, three‐dimensional bioprinting, and smart wearables are highlighted to ...
Xinwei Wang +9 more
wiley +1 more source
Pathogenic or Likely Pathogenic GRN Variants Are Found in 0.1% of Parkinson's Disease Patients
Movement Disorders, Volume 41, Issue 4, Page 1020-1027, April 2026.Abstract Background Parkinsonism may be observed in multiple neurodegenerative diseases, including GRN‐associated frontotemporal dementia (FTD‐GRN), complicating the differential diagnosis of Parkinson's disease (PD). Objectives To investigate the presence of GRN variants in a large group of PD patients.
Christian A. Ganoza +31 more
wiley +1 more source
Alzheimer's disease drug development pipeline: 2026
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.Abstract INTRODUCTION Discovery and development of new therapies for Alzheimer's disease (AD) are urgently needed to address the world's growing population of individuals on the AD pathophysiological continuum. Clinicaltrials.gov is a resource for studying drugs in development for treatment of AD. RESULTS There are currently 158 drugs in 192 AD trials.
Jeffrey L. Cummings +6 more
wiley +1 more source
Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?
Arthritis &Rheumatology, Volume 78, Issue 3, Page 548-557, March 2026.Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin +11 more
wiley +1 more source
Progranulin in neurodegenerative diseases
Postępy Higieny i Medycyny Doświadczalnej, 2018 Neurodegenerative diseases as a group of congenital or acquired diseases of the nervous system are currently more common in the aging societies, being one of the most severe diseases faced the healthcare services. Many scientific teams are searching for a better understanding of the mechanisms of these diseases, i.e.
Barbara Harmata +3 more
openaire +1 more source
Progranulin Deficient Mice Develop Nephrogenic Diabetes Insipidus [PDF]
Aging and disease, 2018 Loss-of-function mutations of progranulin are associated with frontotemporal dementia in humans, and its deficiency in mice is a model for this disease but with normal life expectancy and mild cognitive decline on aging. The present study shows that aging progranulin deficient mice develop progressive polydipsia and polyuria under standard housing ...
Hardt, Stefanie +5 more
openaire +4 more sources
Expression of the growth factor progranulin in endothelial cells influences growth and development of blood vessels: a novel mouse model. [PDF]
PLoS ONE, 2013 Progranulin is a secreted glycoprotein that regulates cell proliferation, migration and survival. It has roles in development, tumorigenesis, wound healing, neurodegeneration and inflammation.
Huishi Toh +3 more
doaj +1 more source
Digital detection of exosomes by interferometric imaging [PDF]
, 2016 Exosomes, which are membranous nanovesicles, are actively released by cells and have been attributed to roles in cell-cell communication, cancer metastasis, and early disease diagnostics.
Benussi, Luisa +13 more
core +2 more sources