Results 91 to 100 of about 7,247 (208)

Genetically programmed changes in transcription of the novel progranulin regulator [PDF]

, 2020
: Progranulin is a glycoprotein marking chronic inflammation in obesity and type 2 diabetes. Previous studies suggested PSRC1 (proline and serine rich coiled-coil 1) to be a target of genetic variants associated with serum progranulin levels. We aimed to
Keller, M., Schleinitz, D., Böttcher, Y., Keller, Maria,, Tönjes, Anke, Stumvoll, Michael,, Schleinitz, Dorit,, Heyne, H., Huth, Sandra, Scholz, M., Keller, Maria, Huth, Sandra,, Heyne, Henrike O., Gebhardt, C., Gebhardt, Claudia,, Tönjes, Anke,, Stumvoll, M., Huth, S., Böttcher, Yvonne, Kovacs, P., Scholz, Markus,, Gebhardt, Claudia, Scholz, Markus, Heyne, Henrike,, Kovacs, Peter,, Kovacs, Peter, Heyne, Henrike, Schleinitz, Dorit, Tönjes, A., Böttcher, Yvonne,, Stumvoll, Michael, Lund University.   +31 more
core   +1 more source

Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway [PDF]

, 2019
Deficient progranulin levels cause dose-dependent neurological syndromes: haploinsufficiency leads to frontotemporal lobar degeneration (FTLD) and nullizygosity produces adult-onset neuronal ceroid lipofuscinosis.
Mason, Amanda R, Finkbeiner, Steven, Elia, Lisa P, Alijagic, Amela   +3 more
core   +1 more source

Exploring the Potential of Calebin‐A in Targeting Obesity‐Related Genes and Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Obesity is a global health crisis affecting millions, associated with metabolic disorders such as type 2 diabetes and cardiovascular disease. Calebin‐A, a bioactive compound derived from Curcuma species, has shown promise in managing obesity and its complications.
Ali Mahmoudi, Ali Saeedi‐Boroujeni, Sercan Karav, Prashant Kesharwani, Amirhossein Sahebkar   +4 more
wiley   +1 more source

Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy

Neurobiology of Disease, 2016
Peripheral or central nerve injury is a frequent cause of chronic pain and the mechanisms are not fully understood. Using newly generated transgenic mice we show that progranulin overexpression in sensory neurons attenuates neuropathic pain after sciatic
Christine Altmann, Stefanie Hardt, Caroline Fischer, Juliana Heidler, Hee-Young Lim, Annett Häussler, Boris Albuquerque, Béla Zimmer, Christine Möser, Christian Behrends, Frank Koentgen, Ilka Wittig, Mirko H.H. Schmidt, Albrecht M. Clement, Thomas Deller, Irmgard Tegeder   +15 more
doaj   +1 more source

scRNA‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 6, Page 1078-1090, June 2026.
CCR4 was expressed in malignant clones and regulatory T cells in untreated CTCL, that were decreased in MAR. Malignant clones in MAR showed a silenced phenotype with decreases in central memory markers SELL and CCR7, and GTP‐binding member GIMAP7 and upregulation of MMP2 inhibitor TIMP2 and tumour suppressor gene RUNX3.
Shannon Meledathu, Agata Kurowski, Malini P. Naidu, Jonas Adalsteinsson, Shane A. Meehan, Natalia Alkon, Lauren R. Port, Sumanth Chennareddy, Emry R. Cohenour, Grace Christensen, Jonah Shulman, Nicholas Gulati, Constanze Jonak, Patrick M. Brunner   +13 more
wiley   +1 more source

Progranulin: normal function and role in neurodegeneration [PDF]

Journal of Neurochemistry, 2007
AbstractProgranulin (PGRN) is a multifunctional protein that has attracted significant attention in the neuroscience community following the recent discovery of PGRN mutations in some cases of frontotemporal dementia. Most of the pathogenic mutations result in null alleles, and it is thought that frontotemporal dementia in these families results from ...
Jason L, Eriksen, Ian R A, Mackenzie
openaire   +2 more sources

Optimization of Progranulin Gene Therapy, a Potential Treatment for Frontotemporal Dementia [PDF]

, 2023
Heterozygous loss of function mutations in the progranulin gene cause frontotemporal dementia, characterized by deficits in social behavior, language comprehension and motor function.
Kashyap, Shreya Natesh
core   +1 more source

Yeast-2-Hybrid data file showing progranulin interactions in human fetal brain and bone marrow libraries

Data in Brief, 2016
Progranulin deficiency in humans is associated with neurodegeneration. Its mechanisms are not yet fully understood. We performed a Yeast-2-Hybrid screen using human full-length progranulin as bait to assess the interactions of progranulin.
Irmgard Tegeder
doaj   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, Volume 13, Issue 28, 18 May 2026.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Reduction of Sphingomyelinases Associated with Progranulin Deficiency and Frontotemporal Dementia [PDF]

, 2023
Frontotemporal dementia (FTD) is a leading cause of early-onset dementia and has a significant socioeconomic burden due to difficulties in diagnosis and delay to diagnosis. FTD is a clinically, pathologically, and genetically heterogeneous disorder.
Boyle, Nicholas R
core   +1 more source