Results 91 to 100 of about 7,909 (155)

The Role of Progranulin in Frontotemporal Dementia [PDF]

Frontotemporal dementia (FTD) is one of the most common forms of presenile dementia with a cost per patient per year greater than Alzheimer's disease.
Werthmann, Gordon Chandler
core   +1 more source

A novel oncogenic protein in the Progranulin\EphA2 axis: the role of Myoferlin in bladder cancer

, 2022
reservedThe growth factor progranulin plays a key role in bladder cancer by promoting cell motility and invasion. Until recently, the progranulin signaling receptor remained unknown precluding a full comprehension of progranulin action in cancer.
RUGGIERO, VALENTINA
core  

Progranulin and Vaspin as Potential Novel Markers in the Etiology of Type 1 Diabetes in Children

Medicina
Background and Objectives: Diabetes is a significant health problem, prompting the search for new therapeutic strategies. Recently, researchers have focused on identifying novel markers for the progression of this condition.
Katarzyna Jakubek-Kipa, Sabina Galiniak, Artur Mazur   +2 more
doaj   +1 more source

Elevated plasma progranulin levels in the acute phase are correlated with recovery of left ventricular function in the chronic phase in patients with acute myocardial infarction.

PLoS ONE
BackgroundProgranulin is a secreted glycoprotein that regulates inflammation and wound healing. However, plasma progranulin levels in the acute phase and their clinical significance in patients with acute myocardial infarction (AMI) remain to be ...
Shingo Minatoguchi, Atsushi Satake, Hirotaka Murase, Ryo Yoshizumi, Hisaaki Komaki, Shinya Baba, Shinji Yasuda, Shinsuke Ojio, Toshiki Tanaka, Hiroyuki Okura, Shinya Minatoguchi   +10 more
doaj   +1 more source

Another piece in the progranulin puzzle: special binding between progranulin and prosaposin creates additional lysosomal access

, 2017
Loss-of-function mutations in the gene encoding the growth factor progranulin cause degeneration of the ageing brain in a dose-dependent manner. While heterozygous mutations result in adult onset frontotemporal dementia, the much rarer homozygous null ...
Van Damme, Philip, Philip Van Damme
core   +1 more source

The adipokines progranulin and omentin – novel regulators of basic ovarian cell functions

Reproductive Biology and Endocrinology
The present study aimed to examine the effects of progranulin and omentin on basic ovarian cell functions. For this purpose, we investigated the effects of the addition of progranulin and omentin (0, 0.1, 1, or 10 ng/ml) on the viability, proliferation ...
Alexander V Sirotkin, Zuzana Fabová, Barbora Loncová, Maria Bauerová, Abdel Halim Harrath   +4 more
doaj   +1 more source

Functional characterization of progranulin in wound healing and tumorigenesis

, 2001
The human progranulin gene encodes a 593 amino acid secreted glycoprotein, progranulin (also called PC cell-derived growth factor, acrogranin or granulin/epithelin precursor). The biological activities of this protein were poorly defined at the beginning
He, Zhiheng, 1971-
core  

Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin. [PDF]

, 2016
We have recently demonstrated a critical role for progranulin in bladder cancer. Progranulin contributes, as an autocrine growth factor, to the transformed phenotype by modulating Akt-and MAPK-driven motility, invasion and anchorage-independent growth ...
Morcavallo, Alaide, Peiper, Stephen C., Gomella, Leonard G., Genua, Marco, Moskalev, Igor, Xu, Shi-Qiong, Stefanello, Manuela, Birbe, Ruth, Belfiore, Antonino, Iozzo, Renato V., Tanimoto, Ryuta, Black, Peter C., Buraschi, Simone, Morrione, Andrea   +13 more
core  

AZP2006 in Parkinson's disease models: A promising new neuroprotective treatment involving lysosomal homeostasis and the Progranulin/Prosaposin complex. [PDF]

PLoS One
Callizot N, Culley G, Flower G, Rouvière L, De Conto V, Wojcinski A, Botto C, Estrella C, Henriques A, Verwaerde P.   +9 more
europepmc   +1 more source

Diagnostic accuracy of synovial fluid progranulin vs. C-reactive protein in septic arthritis: a comparative biomarker study. [PDF]

Adv Rheumatol
Savaş T, Koçer İ, Albayrak F, Savaş NY, Karabulut Ç, Kısacık B.   +5 more
europepmc   +1 more source