Results 91 to 100 of about 11,442 (213)

Graphene Triggers Inflammation in Murine Microglia via Phagocytosis

Small Science, Volume 6, Issue 3, March 2026.
Phagocytosis of single‐layer graphene by microglia triggers inflammatory activation without cytotoxicity. Small carbon nanotubes elicit similar responses, whereas larger graphene nanoplatelets do not. Proteomic analysis reveals effects on inflammation, cytoskeleton, and proliferation, highlighting the importance of graphene stability for safe neural ...
Pratika Rai, Robert Subirana Slotos, Ahmar Hasnain, Emma Walter, Marina Mantellatto Grigoli, Irini Petrou, Mario Dejung, Jia‐Xuan Chen, Oliver Tüscher, Alexey Tarasov, Kristina Endres   +10 more
wiley   +1 more source

The Evolution of the Secreted Regulatory Protein Progranulin. [PDF]

PLoS ONE, 2015
Progranulin is a secreted growth factor that is active in tumorigenesis, wound repair, and inflammation. Haploinsufficiency of the human progranulin gene, GRN, causes frontotemporal dementia.
Roger G E Palfree, Hugh P J Bennett, Andrew Bateman   +2 more
doaj   +1 more source

A novel role for drebrin in regulating progranulin bioactivity in bladder cancer. [PDF]

, 2015
We recently established a critical role for the growth factor progranulin in bladder cancer insofar as progranulin promotes urothelial cancer cell motility and contributes, as an autocrine growth factor, to the transformed phenotype by modulating ...
Belfiore, Antonino, Birbe, Ruth, Buraschi, Simone, Genua, Maro, Gomella, Leonard G., Iozzo, Renato V., Morcavallo, Alaide, Morrione, Andrea, Morrione|, Peiper, Stephen C., Shirao, Tomoaki, Xi, Shi-Qiong   +11 more
core   +3 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, Volume 20, Issue 2, Page 226-247, February 2026.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy

Neurobiology of Disease, 2016
Peripheral or central nerve injury is a frequent cause of chronic pain and the mechanisms are not fully understood. Using newly generated transgenic mice we show that progranulin overexpression in sensory neurons attenuates neuropathic pain after sciatic
Christine Altmann, Stefanie Hardt, Caroline Fischer, Juliana Heidler, Hee-Young Lim, Annett Häussler, Boris Albuquerque, Béla Zimmer, Christine Möser, Christian Behrends, Frank Koentgen, Ilka Wittig, Mirko H.H. Schmidt, Albrecht M. Clement, Thomas Deller, Irmgard Tegeder   +15 more
doaj   +1 more source

Glycans and glycosaminoglycans in neurobiology: key regulators of neuronal cell function and fate [PDF]

, 2018
The aim of the present study was to examine the roles of l-fucose and the glycosaminoglycans (GAGs) keratan sulfate (KS) and chondroitin sulfate/dermatan sulfate (CS/DS) with selected functional molecules in neural tissues.
Hayes, Anthony J., Melrose, James
core   +2 more sources

Astrocytic PYGM attenuates tau pathology by promoting lactate‐mediated neuroprotection

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Tauopathies are characterized by hyperphosphorylated tau accumulation and neurodegeneration. Although astrocytic metabolism is known to support neuronal health, the role of astrocytic glycogen metabolism, particularly the glycogenolytic enzyme PYGM (glycogen phosphorylase, muscle associated), in tauopathies remains unclear ...
Jing Cao, Jian Meng, Yiqing Chen, Ziqian Tang, Yong Wang, Kun Li, Xian Zhang, Hong Luo, Huihui Li, Zhanxiang Wang, Yun‐wu Zhang   +10 more
wiley   +1 more source

Gene expression profiling of cutaneous wound healing [PDF]

, 2007
Background Although the sequence of events leading to wound repair has been described at the cellular and, to a limited extent, at the protein level this process has yet to be fully elucidated.
Wang Ena, Norwood Christopher, Slade Herbert B, Smith Kina, Jin Ping, Stashower Mitchell E, Panelli Monica C, Deonarine Kavita, Marincola Francesco M, Stroncek David F   +9 more
core   +2 more sources

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source

Yeast-2-Hybrid data file showing progranulin interactions in human fetal brain and bone marrow libraries

Data in Brief, 2016
Progranulin deficiency in humans is associated with neurodegeneration. Its mechanisms are not yet fully understood. We performed a Yeast-2-Hybrid screen using human full-length progranulin as bait to assess the interactions of progranulin.
Irmgard Tegeder
doaj   +1 more source