Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia [PDF]
, 2016 [Background] Mutations in the progranulin gene (GRN) are the most common cause of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). TDP-43 pathology is characterized by the hyperphosphorylation of the protein at Serine
Carolina Alquezar +8 more
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Recent biomarker approaches in the diagnosis of frontotemporal lobar degeneration/Neurochemische Ansätze in der Diagnose der Frontotemporalen Lobärdegeneration [PDF]
, 2017 Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of syndromes with different symptoms. Frontotemporal lobar degeneration is mostly used as a clinical umbrella term for different diseases. In some clinical subtypes of the FTLD spectrum, a
Feneberg, Emily +4 more
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The clinical spectrum of sporadic and familial forms of frontotemporal dementia [PDF]
, 2016 The term frontotemporal dementia (FTD) describes a clinically, genetically and pathologically diverse group of neurodegenerative disorders. Symptoms of FTD can present in individuals in their twenties through to their nineties, but the mean age at onset ...
Rohrer, JD, Woollacott, IO
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Evaluation of progranulin and inflammatory markers in the diagnosis of acute cholecystitis
Medicine ScienceThis study aimed to investigate the role of inflammatory markers and progranulin levels in diagnosing cholecystitis, assessing their potential as diagnostic biomarkers. The research involved 54 patients diagnosed with acute cholecystitis in the emergency
Ali Ihsan Kilci +5 more
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Progranulin deficiency leads to reduced glucocerebrosidase activity
PLOS ONE, 2019 Mutation in the GRN gene, encoding the progranulin (PGRN) protein, shows a dose-dependent disease correlation, wherein haploinsufficiency results in frontotemporal lobar degeneration (FTLD) and complete loss results in neuronal ceroid lipofuscinosis (NCL).
Zhou, X. +9 more
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Nature CommunicationsHeterozygous loss-of-function mutations in the GRN gene are a major cause of hereditary frontotemporal dementia. The mechanisms linking frontotemporal dementia pathogenesis to progranulin deficiency are not well understood, and there is currently no ...
Rachel Tesla +13 more
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Mediators of Inflammation, 2013 Insulin resistance (IR) is considered to be one of the most important pathogenesis of glycolipid metabolism disorders. However, the molecular mechanism responsible for IR is not fully understood. Recently, the chronic inflammation has been proposed to be
Hua Qu, Huacong Deng, Zhenping Hu
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An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations [PDF]
, 2017 et al,, Fagan, Anne M
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Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice1,2,3
, 2015 Loss-of-function mutations in progranulin (GRN) are one of the most common genetic causes of frontotemporal dementia (FTD), a progressive, fatal neurodegenerative disorder with no available disease-modifying treatments. Through haploinsufficiency, these mutations reduce levels of progranulin, a protein that has neurotrophic and anti-inflammatory ...
Arrant, Andrew E. +2 more
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Progranulin and Vaspin as Potential Novel Markers in the Etiology of Type 1 Diabetes in Children
MedicinaBackground and Objectives: Diabetes is a significant health problem, prompting the search for new therapeutic strategies. Recently, researchers have focused on identifying novel markers for the progression of this condition.
Katarzyna Jakubek-Kipa +2 more
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