Results 111 to 120 of about 7,247 (208)

Functional characterization of progranulin in wound healing and tumorigenesis [PDF]

, 2001
The human progranulin gene encodes a 593 amino acid secreted glycoprotein, progranulin (also called PC cell-derived growth factor, acrogranin or granulin/epithelin precursor). The biological activities of this protein were poorly defined at the beginning
He, Zhiheng, 1971-
core  

Prävalenz der Progranulin-Autoantikörper bei seropositiver und seronegativer rheumatoider Arthritis [PDF]

, 2017
In dieser Studie wurde eine repräsentative Kohorte von Patienten mit rheumatoider Arthritis auf Serum Progranulin-Antikörper untersucht und ausführlich charakterisiert.
Gerling, Moritz
core   +1 more source

A novel role for drebrin in regulating progranulin bioactivity in bladder cancer. [PDF]

, 2015
We recently established a critical role for the growth factor progranulin in bladder cancer insofar as progranulin promotes urothelial cancer cell motility and contributes, as an autocrine growth factor, to the transformed phenotype by modulating ...
Morcavallo, Alaide, Peiper, Stephen C., Gomella, Leonard G., Peiper, Stephen C, Genua, Marco, Xu, Shi-Qiong, Gomella, Leonard G, Shirao, Tomoaki, Birbe, Ruth, Iozzo, Renato V, Genua, Maro, Belfiore, Antonino, Iozzo, Renato V., Buraschi, Simone, Morrione, Andrea, Xi, Shi-Qiong, Morrione|   +16 more
core   +2 more sources

Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin. [PDF]

, 2016
We have recently demonstrated a critical role for progranulin in bladder cancer. Progranulin contributes, as an autocrine growth factor, to the transformed phenotype by modulating Akt-and MAPK-driven motility, invasion and anchorage-independent growth ...
Morcavallo, Alaide, Peiper, Stephen C., Gomella, Leonard G., Genua, Marco, Moskalev, Igor, Xu, Shi-Qiong, Stefanello, Manuela, Birbe, Ruth, Belfiore, Antonino, Iozzo, Renato V., Tanimoto, Ryuta, Black, Peter C., Buraschi, Simone, Morrione, Andrea, Xi, Shi-Qiong, Morrione|   +15 more
core   +2 more sources

Evaluation of progranulin and inflammatory markers in the diagnosis of acute cholecystitis

Medicine Science
This study aimed to investigate the role of inflammatory markers and progranulin levels in diagnosing cholecystitis, assessing their potential as diagnostic biomarkers. The research involved 54 patients diagnosed with acute cholecystitis in the emergency
Ali Ihsan Kilci, Muhammed Seyithanoglu, Erhan Kaya, Hakan Hakkoymaz, Muhammed Semih Gedik, Omer Faruk Kucuk   +5 more
doaj   +1 more source

Progranulin and Granulin Titration Modulates Animal Fitness through Lysosomal Regulation [PDF]

, 2023
Progranulin is an evolutionarily conserved protein. Insufficient levels have been implicated in frontotemporal lobar degeneration with TDP-43 aggregates.
Wang, Austin
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Progranulin mutations as risk factors for Alzheimer disease. [PDF]

, 2013
ImportanceMutations in the progranulin gene are known to cause diverse clinical syndromes, all attributed to frontotemporal lobar degeneration. We describe 2 patients with progranulin gene mutations and evidence of Alzheimer disease (AD) pathology.
Lehmann, Manja, Coppola, Giovanni, Grinberg, Lea T, Lee, Jason Jiyong, Geschwind, Dan, Karydas, Anna, Seeley, William W, Yokoyama, Jennifer S, Rabinovici, Gil, Rosen, Howard, Perry, David C, Miller, Bruce L   +11 more
core   +1 more source

Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency

Nature Communications
Heterozygous loss-of-function mutations in the GRN gene are a major cause of hereditary frontotemporal dementia. The mechanisms linking frontotemporal dementia pathogenesis to progranulin deficiency are not well understood, and there is currently no ...
Rachel Tesla, Charlotte Guhl, Gordon C. Werthmann, Danielle Dixon, Basar Cenik, Yesu Addepalli, Jue Liang, Daniel M. Fass, Zachary Rosenthal, Stephen J. Haggarty, Noelle S. Williams, Bruce A. Posner, Joseph M. Ready, Joachim Herz   +13 more
doaj   +1 more source

The Role of Progranulin in Frontotemporal Dementia [PDF]

Frontotemporal dementia (FTD) is one of the most common forms of presenile dementia with a cost per patient per year greater than Alzheimer's disease.
Werthmann, Gordon Chandler
core   +1 more source

Plasma Progranulin Concentrations Are Increased in Patients with Type 2 Diabetes and Obesity and Correlated with Insulin Resistance

Mediators of Inflammation, 2013
Insulin resistance (IR) is considered to be one of the most important pathogenesis of glycolipid metabolism disorders. However, the molecular mechanism responsible for IR is not fully understood. Recently, the chronic inflammation has been proposed to be
Hua Qu, Huacong Deng, Zhenping Hu
doaj   +1 more source