Results 101 to 110 of about 7,247 (208)

Progranulin in neurodegenerative diseases

Postępy Higieny i Medycyny Doświadczalnej, 2018
Neurodegenerative diseases as a group of congenital or acquired diseases of the nervous system are currently more common in the aging societies, being one of the most severe diseases faced the healthcare services. Many scientific teams are searching for a better understanding of the mechanisms of these diseases, i.e.
Barbara Harmata, Halina Jędrzejowska-Szypułka, Katarzyna Pawletko, Joanna Lewin-Kowalik   +3 more
openaire   +1 more source

Cognitive dispersion profiles and prediction of cognitive change in early‐onset dementias: Results from LEADS

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Research into cognitive dispersion – a cognitive process score measuring the intra‐individual variability (IIV) across a single testing session – suggests utility in neurodegenerative populations. Given widespread deficits observed in sporadic early‐onset Alzheimer's disease (EOAD), however, it is unclear if examining cognitive ...
Dustin B. Hammers, Elodie Foster, Ani Eloyan, Maryanne Thangarajah, Alexander Taurone, Alexandra Touroutoglou, Renaud La Joie, Laurel Beckett, Sujuan Gao, Prashanthi Vemuri, Kelly N. Nudelman, Kala Kirby, Jeffrey L. Dage, Paul Aisen, Alireza Atri, David Clark, Gregory S. Day, Ranjan Duara, Neill R. Graff‐Radford, Ian Grant, Lawrence S. Honig, Erik C. B. Johnson, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Leila Parand, Kyle Womack, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon J. Sha, Raymond Scott Turner, Thomas S. Wingo, David A. Wolk, Bradford C. Dickerson, Gil D. Rabinovici, Maria C. Carrillo, Liana G. Apostolova, the LEADS Consortium   +40 more
wiley   +1 more source

Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy.

PLoS ONE, 2010
Mislocalization, aberrant processing and aggregation of TAR DNA-binding protein 43 (TDP-43) is found in the neurons affected by two related diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal lobe dementia (FTLD).
Angela S Laird, Annelies Van Hoecke, Louis De Muynck, Mieke Timmers, Ludo Van den Bosch, Philip Van Damme, Wim Robberecht   +6 more
doaj   +1 more source

Serum progranulin levels are associated with frailty in middle-aged individuals.

PLoS ONE, 2020
Background and objectiveA recent study identified progranulin as a candidate biomarker for frailty, based on gene expression databases. In the present study, we investigated associations between serum progranulin levels and frailty in a population-based ...
Andrew D Nguyen, Theodore K Malmstrom, Michael L Niehoff, Asef Aziz, Douglas K Miller, John E Morley   +5 more
doaj   +1 more source

Glucose metabolic reprogramming as a driver of immunosuppression in the tumour microenvironment

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Glucose metabolic reprogramming is a central driver of immunosuppression in the tumour microenvironment, orchestrating immune dysfunction through multiple interconnected mechanisms. Glucose competition establishes a selective bioenergetic hierarchy that constrains antitumour immunity, whereas lactate accumulation and its reciprocal crosstalk with ...
Yang Wang, Yijun Lu, Jian Zhou, Xinrong Yang   +3 more
wiley   +1 more source

Tweaking Progranulin Expression

Frontiers in molecular neuroscience, 2021
Frontotemporal dementia (FTD) is a neurodegenerative disease, leading to behavioral changes and language difficulties. Heterozygous loss-of-function mutations in progranulin (GRN) induce haploinsufficiency of the protein and are associated with up to one-third of all genetic FTD cases worldwide.
Terryn, Joke, Verfaillie, Catherine M., van Damme, Philip   +2 more
openaire   +1 more source

Serum progranulin levels are elevated in infertile women with obesity [PDF]

, 2018
Introduction: The aim of the present study was to investigate the changes in serum progranulin and sex hormone levels in infertile women with obesity.
Bostanci, Mehmet Omar; Department of Ophthalmology, Hitit University Medical School, Çorum, Türkiye, Gorkem, Umit; Department of Ophthalmology, Hitit University Medical School, Çorum, Türkiye, Inal, Zeynep Ozturk; Konya Education and Research Hospital, Konya, Türkiye, Inal, Hasan Ali; Konya Education and Research Hospital, Konya, Türkiye   +3 more
core   +2 more sources

Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice1,2,3

, 2015
Loss-of-function mutations in progranulin (GRN) are one of the most common genetic causes of frontotemporal dementia (FTD), a progressive, fatal neurodegenerative disorder with no available disease-modifying treatments. Through haploinsufficiency, these mutations reduce levels of progranulin, a protein that has neurotrophic and anti-inflammatory ...
Arrant, Andrew E., Patel, Aashka R., Roberson, Erik D.   +2 more
openaire   +1 more source

The perlecan-interacting growth factor progranulin regulates ubiquitination, sorting, and lysosomal degradation of sortilin [PDF]

, 2017
Despite extensive clinical and experimental studies over the past decades, the pathogenesis and progression to the castration-resistant stage of prostate cancer remains largely unknown.
Gomella, Leonard G., Peiper, Stephen C., Neill, Thomas, Belfiore, Antonino, Xu, Shi-Qiong, Tanimoto, Ryuta, Iozzzo, Renato V., Buraschi, Simone, Morrione, Andrea, Palladino, Chiara, Morrione|   +10 more
core   +1 more source

Another piece in the progranulin puzzle: special binding between progranulin and prosaposin creates additional lysosomal access [PDF]

, 2017
Loss-of-function mutations in the gene encoding the growth factor progranulin cause degeneration of the ageing brain in a dose-dependent manner. While heterozygous mutations result in adult onset frontotemporal dementia, the much rarer homozygous null ...
Van Damme, Philip, Philip Van Damme
core   +1 more source