Results 101 to 110 of about 11,442 (213)

Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer’s disease Ibero-American cohort [PDF]

, 2012
INTRODUCTION: Some familial Alzheimer's disease (AD) cases are caused by rare and highly-penetrant mutations in APP, PSEN1, and PSEN2. Mutations in GRN and MAPT, two genes associated with frontotemporal dementia (FTD), have been found in clinically ...
Benitez, Bruno A, Cervantes, Sebastian, Cooper, Breanna, Cruchaga, Carlos, Goate, Alison, Ibero-American Alzheimer Disease Genetics Group Researchers,, Jin, Sheng C, Pastor, Pau, Razquin, Cristina   +8 more
core   +2 more sources

An Impedimetric Immunosensor for Progranulin Detection Using Streptavidin‐Biotin Conjugation on Carbon Screen‐Printed Electrodes

Advanced Sensor Research, Volume 5, Issue 1, January 2026.
Glycoprotein 88 (GP88) is a secreted biomarker that is overexpressed in various cancers, neurological diseases such as Alzheimer's and Dementia, and inflammatory disorders. A disposable, rapid testing device for GP88 detection provides immediate marker‐level results, helping doctors monitor disease progression and therapy effectiveness. When optimized,
Elham Rezaee, Madeline Nowlan, Anna Ignaszak   +2 more
wiley   +1 more source

Antibody Characterization Report for Progranulin

, 2022
Head-to-head comparison of available commercial antibodies against Progranulin by immunoblot (Western blot), immunoprecipitation and immunofluorescence. The following study was funded in part by Genome Québec's Genomics Integration Program, awarded to the research laboratory of Peter S. McPherson. This work is supported by the ALS-Reproducible Antibody
Alshafie, Walaa, Fotouhi, Maryam, Ayoubi, Riham, McPherson, Peter S., Laflamme, Carl   +4 more
openaire   +1 more source

Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy.

PLoS ONE, 2010
Mislocalization, aberrant processing and aggregation of TAR DNA-binding protein 43 (TDP-43) is found in the neurons affected by two related diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal lobe dementia (FTLD).
Angela S Laird, Annelies Van Hoecke, Louis De Muynck, Mieke Timmers, Ludo Van den Bosch, Philip Van Damme, Wim Robberecht   +6 more
doaj   +1 more source

Primary Phagocytosis of Neurons by Inflamed Microglia: Potential Roles in Neurodegeneration [PDF]

, 2012
Microglial phagocytosis of dead or dying neurons can be beneficial by preventing secondary necrosis and release of pro-inflammatory intracellular components.
Jonas J. Neher, Urte Neniskyte, Guy C. Brown   +2 more
core   +2 more sources

Cover Feature: An Impedimetric Immunosensor for Progranulin Detection Using Streptavidin‐Biotin Conjugation on Carbon Screen‐Printed Electrodes (Adv. Sensor Res. 1/2026)

Advanced Sensor Research, Volume 5, Issue 1, January 2026.
Electrochemical Immunosensor Glycoprotein 88 (GP88) is a secreted biomarker that is overexpressed in various cancers, as well as in neurological and inflammatory diseases. In the Research Article (DOI: 10.1002/adsr.202500122), Anna Ignaszak and co‐workers introduce the first disposable electrochemical immunosensor built on a screen‐printed electrode ...
Elham Rezaee, Madeline Nowlan, Anna Ignaszak   +2 more
wiley   +1 more source

Serum progranulin levels are associated with frailty in middle-aged individuals.

PLoS ONE, 2020
Background and objectiveA recent study identified progranulin as a candidate biomarker for frailty, based on gene expression databases. In the present study, we investigated associations between serum progranulin levels and frailty in a population-based ...
Andrew D Nguyen, Theodore K Malmstrom, Michael L Niehoff, Asef Aziz, Douglas K Miller, John E Morley   +5 more
doaj   +1 more source

Alzheimer's disease polygenic risk in early‐ and late‐onset Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION The genetic basis of sporadic early‐onset Alzheimer's disease (EOAD) remains largely unknown, prompting evaluation of late‐onset Alzheimer's disease (LOAD) polygenic risk in EOAD. METHODS A LOAD polygenic score (PGS) was calculated in the Longitudinal Early‐onset Alzheimer's Disease Study (LEADS) and Alzheimer's Disease ...
Julian V. Pentchev, Trever Jackson, Naazneen Khan, Thea J. Rosewood, Yen‐Ning Huang, Kwangsik Nho, Andrew J. Saykin, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Meghan Riddle, Steven Salloway, Alireza Atri, Lawrence S. Honig, Erik C. B. Johnson, Raymond Scott Turner, Joseph C. Masdeu, Tatiana M. Foroud, David Clark, Dustin B. Hammers, Jeffrey L. Dage, Kala Kirby, Bernardino Ghetti, Kathy Newell, Chiadi U. Onyike, Gregory S. Day, Neill R. Graff‐Radford, Melissa E. Murray, David T. Jones, Clifford R. Jack Jr., Prashanthi Vemuri, Alexandra Touroutoglou, Ranjan Duara, Ian Grant, Sharon Sha, Thomas S. Wingo, Laurel A. Beckett, Emily Rogalski, Mario F. Mendez, Joel Kramer, Renaud La Joie, Ganna Blazhenets, Lea T. Grinberg, Robert Koeppe, David A. Wolk, Paul Aisen, Rema Raman, Arthur Toga, Walter A. Kukull, Erik Musiek, Kyle B. Womack, Maria C. Carrillo, Gil D. Rabinovici, Bradford C. Dickerson, Liana G. Apostolova, Kelly N. H. Nudelman, for the Longitudinal Early‐Onset Alzheimer's Disease Study Consortium and the Alzheimer's Disease Neuroimaging Initiative   +56 more
wiley   +1 more source

Correlating familial Alzheimer’s disease gene mutations with clinical phenotype [PDF]

, 2010
Alzheimer’s disease (AD) causes devastating cognitive impairment and an intense research effort is currently devoted to developing improved treatments for it.
Rossor, M.N., Ryan, N.S.
core   +1 more source

Effects of sex hormone treatment on the metabolic syndrome in transgender individuals : focus on metabolic cytokines [PDF]

, 2018
Context: Hormonal treatment in transgender persons affects many components of the metabolic syndrome (MS). Objective: To determine the role of direct hormonal effects, changes in metabolic cytokines, and body composition on metabolic outcomes.
Auer, Matthias K, Defreyne, Justine, Ebert, Thomas, Fuss, Johannes, Pietzner, Maik, Stalla, Guenter K, T'Sjoen, Guy   +6 more
core   +2 more sources