Results 71 to 80 of about 11,442 (213)

Progranulin Oncogenic Network in Solid Tumors

Cancers, 2023
Progranulin is a pleiotropic growth factor with important physiological roles in embryogenesis and maintenance of adult tissue homeostasis. While-progranulin deficiency is associated with a broad range of pathological conditions affecting the brain, such as frontotemporal dementia and neuronal ceroid lipofuscinosis, progranulin upregulation ...
Elisa Ventura, Giacomo Ducci, Reyes Benot Dominguez, Valentina Ruggiero, Antonino Belfiore, Elena Sacco, Marco Vanoni, Renato V. Iozzo, Antonio Giordano, Andrea Morrione   +9 more
openaire   +5 more sources

Progranulin and TMEM106B: when two become wan [PDF]

EMBO reports, 2020
Mutations in GRN, which encodes progranulin, are a common cause of familial frontotemporal dementia (FTD). FTD is a devastating disease characterised by neuronal loss in the frontal and temporal lobes that leads to changes in personality, behaviour and language. There are no effective treatments for this complex condition. TMEM106B is a well-recognised
Emma L Clayton, Adrian M Isaacs
openaire   +3 more sources

Mucosal Progranulin expression is induced by H. pylori, but independent of Secretory Leukocyte Protease Inhibitor (SLPI) expression

BMC Gastroenterology, 2011
Background Mucosal levels of Secretory Leukocyte Protease Inhibitor (SLPI) are specifically reduced in relation to H. pylori-induced gastritis. Progranulin is an epithelial growth factor that is proteolytically degraded into fragments by elastase (the ...
Treiber Gerhard, Schindele Daniel, Schönberg Cornelius, Kuester Doerthe, Wex Thomas, Malfertheiner Peter   +5 more
doaj   +1 more source

Serum progranulin level is associated with disease activity following orthopedic surgery in rheumatoid arthritis patients

Journal of International Medical Research, 2020
Background Few studies have focused on the ability of progranulin to predict postoperative disease activity in rheumatoid arthritis (RA) patients who have undergone surgery. This study evaluated serum progranulin levels in active RA patients and analyzed
Chunyu Kong, Yuquan Shi, Junhua Xu, Zijuan Xiu, Wufang Qi   +4 more
doaj   +1 more source

Increased circulating progranulin is not sufficient to induce cardiac dysfunction or supraventricular arrhythmia

Scientific Reports, 2023
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, and the incidence of new-onset AF has been increasing over the past two decades. Several factors contribute to the risk of developing AF including age, preexisting cardiovascular disease,
Kevin E. McElhanon, Tyler C. Huff, Dinesh Hirenallur-Shanthappa, Russell A. Miller, Nicolas Christoforou   +4 more
doaj   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Potential Mechanisms of Progranulin-deficient FTLD [PDF]

Journal of Molecular Neuroscience, 2011
Frontotemporal lobar dementia (FTLD) is the most common cause of dementia in patients younger than 60 years of age, and causes progressive neurodegeneration of the frontal and temporal lobes usually accompanied by devastating changes in language or behavior in affected individuals.
Michael Emmerson, Ward, Bruce L, Miller
openaire   +2 more sources

Peripheral Innate Immune Activation Correlates With Disease Severity in GRN Haploinsufficiency. [PDF]

, 2019
Objective: To investigate associations between peripheral innate immune activation and frontotemporal lobar degeneration (FTLD) in progranulin gene (GRN) haploinsufficiency. Methods: In this cross-sectional study, ELISA was used to measure six markers of
Allen, Isabel Elaine, Boxer, Adam L, Cobigo, Yann, Heuer, Hilary, Karydas, Anna, Kramer, Joel H, Ljubenkov, Peter A, McGrath, Michael S, Miller, Bruce, Miller, Zachary, Mitic, Laura, Mumford, Paige, Pearlman, Rodney, Rojas, Julio C, Rosen, Howard J, Staffaroni, Adam, Zhang, Jane   +16 more
core   +2 more sources

scRNA‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions

Journal of the European Academy of Dermatology and Venereology, EarlyView.
CCR4 was expressed in malignant clones and regulatory T cells in untreated CTCL, that were decreased in MAR. Malignant clones in MAR showed a silenced phenotype with decreases in central memory markers SELL and CCR7, and GTP‐binding member GIMAP7 and upregulation of MMP2 inhibitor TIMP2 and tumour suppressor gene RUNX3.
Shannon Meledathu, Agata Kurowski, Malini P. Naidu, Jonas Adalsteinsson, Shane A. Meehan, Natalia Alkon, Lauren R. Port, Sumanth Chennareddy, Emry R. Cohenour, Grace Christensen, Jonah Shulman, Nicholas Gulati, Constanze Jonak, Patrick M. Brunner   +13 more
wiley   +1 more source

Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice [PDF]

, 2016
Frontotemporal Dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two neurodegenerative diseases associated to mislocalization and aggregation of TAR DNA-binding protein 43 (TDP-43).
Alfieri, Julio Armando, Müller Igaz, Lionel Ivan, Silva Pinto, Pablo Roberto   +2 more
core   +2 more sources