Results 71 to 80 of about 7,909 (155)
Advanced Healthcare Materials, Volume 15, Issue 24, 25 June 2026.Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni +13 more
wiley +1 more source
Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy
Neurobiology of Disease, 2016 Peripheral or central nerve injury is a frequent cause of chronic pain and the mechanisms are not fully understood. Using newly generated transgenic mice we show that progranulin overexpression in sensory neurons attenuates neuropathic pain after sciatic
Christine Altmann +15 more
doaj +1 more source
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) recently celebrated its 20th anniversary, reflecting two decades of major contributions to Alzheimer's research through open data sharing and longitudinal multimodal assessments. This review synthesizes 122 high‐impact studies using ADNI data or biospecimens from 2023 to mid‐2025 to ...
Dallas P. Veitch +22 more
wiley +1 more source
Data in Brief, 2016 Progranulin deficiency in humans is associated with neurodegeneration. Its mechanisms are not yet fully understood. We performed a Yeast-2-Hybrid screen using human full-length progranulin as bait to assess the interactions of progranulin.
Irmgard Tegeder
doaj +1 more source
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION Women are increasingly entering the dementia research workforce, but they frequently fail to attain senior leadership positions in academia. Discrepancies in academic research outputs were investigated to guide equity‐focused policy recommendations.
Jayalakshmi Viswanathan +18 more
wiley +1 more source
A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology
JOR SPINE, Volume 9, Issue 2, June 2026.A literature‐based signaling network capturing the most relevant pathways in human nucleus pulposus cells was first constructed from curated biological evidence. The network was then translated into a system of ordinary differential equations to derive steady‐state solutions and define median baseline activity levels.
Sofia Tseranidou +11 more
wiley +1 more source
The zebrafish progranulin gene family /
, 2003 Granulins are small cysteine-rich peptide growth factors that, in mammals, are derived from a common glycoprotein precursor (progranulin) containing one half and seven non-identical tandemly repeated granulin domains.
Cadieux, Benoît
core
Serum progranulin levels are associated with frailty in middle-aged individuals.
PLoS ONE, 2020 Background and objectiveA recent study identified progranulin as a candidate biomarker for frailty, based on gene expression databases. In the present study, we investigated associations between serum progranulin levels and frailty in a population-based ...
Andrew D Nguyen +5 more
doaj +1 more source
Analysis of Progranulin-Mediated Akt and MAPK Activation
, 2018 Progranulin has emerged in recent years as an important regulator of various biological functions including cell proliferation, wound healing, motility, and protection from apoptosis.
Renato V. Iozzo +13 more
core +1 more source
, 2015 Frontotemporal dementia (FTD) is the second most common presenile dementia syndrome. Mutations in the GRN gene account for about 20% of patients with familial FTD.
Cenik, Basar 1981-
core +1 more source