Results 51 to 60 of about 7,247 (208)
Outcomes of progranulin gene therapy in the retina are dependent on time and route of delivery
Molecular Therapy: Methods & Clinical Development, 2021 Neuronal ceroid lipofuscinosis (NCL) is a family of neurodegenerative diseases caused by mutations to genes related to lysosomal function. One variant, CNL11, is caused by mutations to the gene encoding the protein progranulin, which regulates neuronal ...
Emilia A. Zin +6 more
doaj +1 more source
Immunity, Inflammation and Disease, 2019 Objective The present study aimed to investigate progranulin autoantibodies in systemic sclerosis and autoimmune connective tissue disorders. Progranulin is a physiologic tumor necrosis factor (TNF) antagonist. Progranulin antibodies decrease progranulin
Philipp Klemm +7 more
doaj +1 more source
Serum Adiponectin and Progranulin Level in Patients with Benign Thyroid Nodule or Papillary Thyroid Cancer [PDF]
Endocrinology and Metabolism, 2020 Background Obesity is associated with thyroid cancer risk. Adiponectin has insulin-sensitizing and anti-inflammatory effects, while progranulin is associated with inflammation and tumorigenesis. We investigated serum adiponectin and progranulin levels in
Hyemi Kwon +3 more
doaj +1 more source
Movement Disorders, EarlyView.Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo +10 more
wiley +1 more source
Progranulin Resolves Inflammation [PDF]
Science, 2011 A molecule binds to a cytokine receptor and limits the cytokine from eliciting inflammatory responses by immune cells.
Hao Wu, Richard M. Siegel
openaire +1 more source
EphA2 is a functional receptor for the growth factor progranulin. [PDF]
, 2016 Although the growth factor progranulin was discovered more than two decades ago, the functional receptor remains elusive. Here, we discovered that EphA2, a member of the large family of Ephrin receptor tyrosine kinases, is a functional signaling receptor
Neill, Thomas +17 more
core +2 more sources
Scientific Reports, 2023 Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, and the incidence of new-onset AF has been increasing over the past two decades. Several factors contribute to the risk of developing AF including age, preexisting cardiovascular disease,
Kevin E. McElhanon +4 more
doaj +1 more source
Microorganisms, 2022 (1) Background: Gastric cancer, the fourth most common cause of death from tumors in the world, is closely associated with Helicobacter pylori. Timely diagnosis, therefore, is essential to achieve a higher survival rate.
Claudia Troncoso +9 more
doaj +1 more source
Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.Abstract INTRODUCTION The impact of different neuropathologies on deep brain structures remains to be understood. We examine subcortical and limbic volumetry in neurodegenerative diseases involving phosphorylated tau (p‐tau), α‐synuclein, and transactive response DNA binding protein 43 (TDP‐43).
Pulkit Khandelwal +30 more
wiley +1 more source
Implication of progranulin and C1q/TNF-related protein-3 (CTRP3) on inflammation and atherosclerosis in subjects with or without metabolic syndrome. [PDF]
PLoS ONE, 2013 Progranulin and C1q/TNF-related protein-3 (CTRP3) were recently discovered as novel adipokines which may link obesity with altered regulation of glucose metabolism, chronic inflammation and insulin resistance.We examined circulating progranulin and CTRP3
Hye Jin Yoo +9 more
doaj +1 more source