Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages [PDF]
, 2018 Background: As crucial regulators of the immune response against pathogens, macrophages have been extensively shown also to be important players in several diseases, including cancer. Specifically, breast cancer macrophages tightly control the angiogenic
Blandino, Giovanni +14 more
core +3 more sources
Progranulin concentration in relation to bone mineral density among obese individuals
Archives of Endocrinology and Metabolism, 2018 Objective Adipose tissue, particularly visceral adipose tissue, secretes a variety of cytokines, among which progranulin is a glycoprotein related to the immune system.
Alireza Milajerdi +4 more
doaj +1 more source
Outcomes of progranulin gene therapy in the retina are dependent on time and route of delivery
Molecular Therapy: Methods & Clinical Development, 2021 Neuronal ceroid lipofuscinosis (NCL) is a family of neurodegenerative diseases caused by mutations to genes related to lysosomal function. One variant, CNL11, is caused by mutations to the gene encoding the protein progranulin, which regulates neuronal ...
Emilia A. Zin +6 more
doaj +1 more source
Progranulin: Functions and neurologic correlations [PDF]
Neurology, 2018 In the Clinical Implications of Neuroscience Research article “Progranulin: Functions and …
openaire +3 more sources
Serum and Urinary Progranulin in Diabetic Kidney Disease. [PDF]
PLoS ONE, 2016 Progranulin has been recognized as an adipokine related to obesity, insulin resistance and type 2 diabetes mellitus (T2DM). There are scarce data regarding progranulin and kidney disease, but there are some data linking diabetic kidney disease (DKD) and ...
Bruna Bellincanta Nicoletto +3 more
doaj +1 more source
Immunity, Inflammation and Disease, 2019 Objective The present study aimed to investigate progranulin autoantibodies in systemic sclerosis and autoimmune connective tissue disorders. Progranulin is a physiologic tumor necrosis factor (TNF) antagonist. Progranulin antibodies decrease progranulin
Philipp Klemm +7 more
doaj +1 more source
Serum Adiponectin and Progranulin Level in Patients with Benign Thyroid Nodule or Papillary Thyroid Cancer [PDF]
Endocrinology and Metabolism, 2020 Background Obesity is associated with thyroid cancer risk. Adiponectin has insulin-sensitizing and anti-inflammatory effects, while progranulin is associated with inflammation and tumorigenesis. We investigated serum adiponectin and progranulin levels in
Hyemi Kwon +3 more
doaj +1 more source
Learning and memory with neuropathic pain: impact of old age and progranulin deficiency [PDF]
, 2013 Persistent neuropathic pain is a frequent consequence of peripheral nerve injuries, particularly in the elderly. Using the IntelliCage we studied if sciatic nerve injury obstructed learning and memory in young and aged mice, each in wild type and ...
Albuquerque, Boris +4 more
core +2 more sources
Annals of Neurology, EarlyView.Objective Immunohistochemically (IHC) measured transactive response DNA‐binding protein 43 (TDP‐43) inclusions are observed in Alzheimer's disease (AD) and are associated with medial temporal lobe atrophy. Accumulation of cryptic exons occurs in AD in response to TDP‐43 pathology.
Hossam Youssef +18 more
wiley +1 more source
Implication of progranulin and C1q/TNF-related protein-3 (CTRP3) on inflammation and atherosclerosis in subjects with or without metabolic syndrome. [PDF]
PLoS ONE, 2013 Progranulin and C1q/TNF-related protein-3 (CTRP3) were recently discovered as novel adipokines which may link obesity with altered regulation of glucose metabolism, chronic inflammation and insulin resistance.We examined circulating progranulin and CTRP3
Hye Jin Yoo +9 more
doaj +1 more source