Results 11 to 20 of about 11,442 (213)
Neurobiology of Disease, 2021 The granulin protein (also known as, and hereafter referred to as, progranulin) is a secreted glycoprotein that contributes to overall brain health. Heterozygous loss-of-function mutations in the gene encoding the progranulin protein (Granulin Precursor,
Terri L. Petkau +7 more
doaj +3 more sources
Neurology, 2018 Progranulin is a highly conserved secreted protein that is expressed in multiple cell types, both in the CNS and in peripheral tissues. Both directly and via its conversion to granulins, progranulin regulates cell growth, survival, repair, and inflammation. Progranulin has a major role in regulation of lysosomal function and microglial responses in the
Ryan A, Townley +2 more
openaire +3 more sources
Progranulin in neurodegenerative dementia [PDF]
Journal of Neurochemistry, 2021 AbstractLong‐term or severe lack of protective factors is important in the pathogenesis of neurodegenerative dementia. Progranulin (PGRN), a neurotrophic factor expressed mainly in neurons and microglia, has various neuroprotective effects such as anti‐inflammatory effects, promoting neuron survival and neurite growth, and participating in normal ...
Xiao‐Ming Wang +4 more
openaire +2 more sources
Can serum progranulin level be used as a prognostic biomarker in non-small cell lung cancer?
Monaldi Archives for Chest Disease, 2022 Progranulin has been considered to be a poor prognostic biomarker for some types of malignancies. However, the clinical significance of serum progranulin level and the prognostic value are still not explored in advanced stages of lung cancer.
Nevin Taci Hoca +4 more
doaj +1 more source
Current Research in Neurobiology, 2023 A growing body of evidence has implicated progranulin in neurodevelopment and indicated that aberrant progranulin expression may be involved in neurodevelopmental disease.
Benjamin Life +4 more
doaj +1 more source
Neurobiology of Disease, 2023 Frontotemporal dementia (FTD) is an early onset dementia characterized by neuropathology and behavioural changes. A common genetic cause of FTD is haploinsufficiency of the gene progranulin (GRN).
Benjamin Life +6 more
doaj +1 more source
Tweaking Progranulin Expression: Therapeutic Avenues and Opportunities [PDF]
Frontiers in Molecular Neuroscience, 2021 Frontotemporal dementia (FTD) is a neurodegenerative disease, leading to behavioral changes and language difficulties. Heterozygous loss-of-function mutations in progranulin (GRN) induce haploinsufficiency of the protein and are associated with up to one-third of all genetic FTD cases worldwide.
Joke Terryn +5 more
openaire +6 more sources
Progranulin protects vascular endothelium against atherosclerotic inflammatory reaction via Akt/eNOS and nuclear factor-κB pathways. [PDF]
PLoS ONE, 2013 OBJECTIVE: Atherosclerosis is considered a chronic inflammatory disease, initiated by activation and dysfunction of the endothelium. Recently, progranulin has been regarded as an important modulator of inflammatory processes; however, the role for ...
Hwan-Jin Hwang +10 more
doaj +1 more source
Heliyon, 2021 Progranulin is an autocrine growth factor that promotes proliferation, migration, invasion, and chemoresistance of various cancer cells. These mechanisms mainly depend on the protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) pathway.
Kuniaki Yabe +7 more
doaj +1 more source
Granulin Knock Out Zebrafish Lack Frontotemporal Lobar Degeneration and Neuronal Ceroid Lipofuscinosis Pathology [PDF]
, 2015 Loss of function mutations in granulin (GRN) are linked to two distinct neurological disorders, frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL).
Haass, C +4 more
core +9 more sources