Results 11 to 20 of about 7,909 (155)

Selective neuronal restoration of progranulin does not prevent the frontotemporal dementia like-phenotype of progranulin knockout mice [PDF]

Journal of Neuroinflammation
Progranulin (PGRN) is a neurotrophic and anti-inflammatory factor produced mainly by neurons and microglia in the central nervous system. Progranulin haploinsufficiency causes frontotemporal dementia (FTD).
Marc-Philipp Weyer, Lisa Hahnefeld, Luisa Franck, Carlo Angioni, Matthias Klein, Gerd Geisslinger, Michael K.E. Schäfer, Irmgard Tegeder   +7 more
doaj   +3 more sources

C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking.

PLoS ONE, 2011
Progranulin haplo-insufficiency is a main cause of frontotemporal lobar degeneration (FTLD) with TDP-43 aggregates. Previous studies have shown that sortilin regulates progranulin trafficking and is a main determinant of progranulin level in the brain ...
Yanqiu Zheng, Owen A Brady, Peter S Meng, Yuxin Mao, Fenghua Hu   +4 more
doaj   +2 more sources

Complexity of progranulin mechanisms of action in mesothelioma [PDF]

Journal of Experimental & Clinical Cancer Research, 2022
Background Mesothelioma is an aggressive disease with limited therapeutic options. The growth factor progranulin plays a critical role in several cancer models, where it regulates tumor initiation and progression.
Elisa Ventura, Christopher Xie, Simone Buraschi, Antonino Belfiore, Renato V. Iozzo, Antonio Giordano, Andrea Morrione   +6 more
doaj   +6 more sources

Low plasma progranulin levels in children with autism

Journal of Neuroinflammation, 2011
Background Autoimmunity to brain may play a pathogenic role in autism. In autoimmune disorders, the formation of antigen-antibody complexes triggers an inflammatory response by inducing the infiltration of neutrophils. Local administration of recombinant
Mostafa Gehan A, AL-Ayadhi Laila Y
doaj   +2 more sources

Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers [PDF]

Frontiers in Endocrinology, 2016
The growth factor progranulin has emerged in recent years as a critical regulator of transformation in several cancer models, including breast cancer, glioblastomas, leukemias and hepatocellular carcinomas. Several laboratories, including ours, have also
Ryuta Tanimoto, Koujung G Lu, Shi-Qiong Xu, Simone Buraschi, Antonino Belfiore, Renato V Iozzo, Andrea Morrione   +6 more
doaj   +3 more sources

Plasma Proteomic Changes in GRN and C9orf72 Frontotemporal Dementia. [PDF]

Eur J Neurol
Multiplex plasma profiling of 124 CNS‐related proteins in genetic frontotemporal dementia (FTD) identified NfL and NfH as the most consistently altered biomarkers in both GRN‐ and C9orf72‐associated disease. Distinct protein changes emerged across genotypes, including changes in GFAP and VCAM1 in GRN‐FTD, and reduced NPTXR as well as nominally altered ...
Simrén J, Benedet AL, Di Molfetta G, Pola I, Tan K, Cantoni V, Libri I, Rivolta J, Ghidoni R, Zetterberg H, Borroni B, Ashton NJ.   +11 more
europepmc   +2 more sources

Progranulin Oncogenic Network in Solid Tumors [PDF]

, 2023
Progranulin is a pleiotropic growth factor with important physiological roles in embryogenesis and maintenance of adult tissue homeostasis. While-progranulin deficiency is associated with a broad range of pathological conditions affecting the brain, such
Ruggiero, Valentina, Sacco, Elena, Iozzo, Renato V, Dominguez, Reyes Benot, Belfiore, Antonino, Vanoni, Marco, Ducci, Giacomo, Giordano, Antonio, Ventura, Elisa, Morrione, Andrea   +9 more
core   +5 more sources

Progranulin Maintains Blood Pressure and Vascular Tone Dependent on EphrinA2 and Sortilin1 Receptors and Endothelial Nitric Oxide Synthase Activation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The mechanisms determining vascular tone are still not completely understood, even though it is a significant factor in blood pressure management. Many circulating proteins have a significant impact on controlling vascular tone.
Ariane Bruder‐Nascimento, Wanessa M. C. Awata, Juliano V. Alves, Shubhnita Singh, Rafael M. Costa, Thiago Bruder‐Nascimento   +5 more
doaj   +1 more source

Can serum progranulin level be used as a prognostic biomarker in non-small cell lung cancer?

Monaldi Archives for Chest Disease, 2022
Progranulin has been considered to be a poor prognostic biomarker for some types of malignancies. However, the clinical significance of serum progranulin level and the prognostic value are still not explored in advanced stages of lung cancer.
Nevin Taci Hoca, Ebru Ünsal, Koza Murat, Arzu Ertürk, Nermin Çapan   +4 more
doaj   +1 more source

The impact of the progranulin-sortilin axis on breast cancer stem cell activity and patient outcome [PDF]

, 2021
Breast cancer is the most common cancer in women worldwide. Still today, despite current breast cancer therapies, many patients experience treatment resistance and relapse, which are believed to be due to failure in targeting treatment-resistant cancer ...
Berger, Karoline
core   +1 more source