Results 11 to 20 of about 7,247 (208)
C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking. [PDF]
PLoS ONE, 2011 Progranulin haplo-insufficiency is a main cause of frontotemporal lobar degeneration (FTLD) with TDP-43 aggregates. Previous studies have shown that sortilin regulates progranulin trafficking and is a main determinant of progranulin level in the brain ...
Yanqiu Zheng +4 more
doaj +4 more sources
Complexity of progranulin mechanisms of action in mesothelioma [PDF]
Journal of Experimental & Clinical Cancer Research, 2022 Background Mesothelioma is an aggressive disease with limited therapeutic options. The growth factor progranulin plays a critical role in several cancer models, where it regulates tumor initiation and progression.
Elisa Ventura +6 more
doaj +8 more sources
Neurobiology of Disease, 2021 The granulin protein (also known as, and hereafter referred to as, progranulin) is a secreted glycoprotein that contributes to overall brain health. Heterozygous loss-of-function mutations in the gene encoding the progranulin protein (Granulin Precursor,
Terri L. Petkau +7 more
doaj +3 more sources
Low plasma progranulin levels in children with autism [PDF]
Journal of Neuroinflammation, 2011 Background Autoimmunity to brain may play a pathogenic role in autism. In autoimmune disorders, the formation of antigen-antibody complexes triggers an inflammatory response by inducing the infiltration of neutrophils. Local administration of recombinant
Mostafa Gehan A, AL-Ayadhi Laila Y
doaj +2 more sources
Cerebrospinal Fluid Progranulin, but Not Serum Progranulin, Is Reduced in GRN-Negative Frontotemporal Dementia. [PDF]
Neuro-degenerative diseases, 2017 Reduced progranulin levels are a hallmark of frontotemporal dementia (FTD) caused by loss-of-function (LoF) mutations in the progranulin gene (GRN). However, alterations of central nervous progranulin expression also occur in neurodegenerative disorders unrelated to GRN mutations, such as Alzheimer's disease.
Wilke, Carlo +10 more
openaire +6 more sources
Progranulin protects vascular endothelium against atherosclerotic inflammatory reaction via Akt/eNOS and nuclear factor-κB pathways. [PDF]
PLoS ONE, 2013 OBJECTIVE: Atherosclerosis is considered a chronic inflammatory disease, initiated by activation and dysfunction of the endothelium. Recently, progranulin has been regarded as an important modulator of inflammatory processes; however, the role for ...
Hwan-Jin Hwang +10 more
doaj +3 more sources
The role of progranulin in the brain [PDF]
, 2014 Frontotemporal lobar degeneration (FTLD) is a devastating, late-onset neurodegenerative disorder that causes profound behavioral abnormalities, language impairment, and alterations in personality in affected patients. As many as 40% of cases have a family history, and of these approximately 25% are due to loss-of-function mutations in the progranulin ...
Petkau, Terri Lynn
openaire +2 more sources
Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers [PDF]
Frontiers in Endocrinology, 2016 The growth factor progranulin has emerged in recent years as a critical regulator of transformation in several cancer models, including breast cancer, glioblastomas, leukemias and hepatocellular carcinomas. Several laboratories, including ours, have also
Ryuta Tanimoto +6 more
doaj +3 more sources
The Evolution of the Secreted Regulatory Protein Progranulin. [PDF]
PLoS ONE, 2015 Progranulin is a secreted growth factor that is active in tumorigenesis, wound repair, and inflammation. Haploinsufficiency of the human progranulin gene, GRN, causes frontotemporal dementia.
Roger G E Palfree +2 more
doaj +3 more sources
Progranulin Oncogenic Network in Solid Tumors [PDF]
, 2023 Progranulin is a pleiotropic growth factor with important physiological roles in embryogenesis and maintenance of adult tissue homeostasis. While-progranulin deficiency is associated with a broad range of pathological conditions affecting the brain, such
Renato V. Iozzo +9 more
core +7 more sources