Results 11 to 20 of about 23,647 (218)
Frontotemporal lobar degeneration
Nature Reviews Disease Primers, 2023 Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset dementia and presents with early social-emotional-behavioural and/or language changes that can be accompanied by a pyramidal or extrapyramidal motor disorder. About 20-25% of individuals with FTLD are estimated to carry a mutation associated with a specific FTLD ...
Murray Grossman +11 more
exaly +13 more sources
Genetics of Frontotemporal Lobar Degeneration [PDF]
Frontiers in Neurology, 2012 Frontotemporal Lobar Degeneration (FTLD) is the most frequent neurodegenerative disorder with a presenile onset. It presents with a spectrum of clinical manifestations, ranging from behavioural and executive impairment to language disorders and motor ...
Daniela eGalimberti, Elio eScarpini
doaj +4 more sources
Frontotemporal Lobar Degeneration and microRNAs [PDF]
Frontiers in Aging Neuroscience, 2016 Frontotemporal lobar degeneration (FTLD) includes a spectrum of disorders characterized by changes of personality and social behaviour and, often, a gradual and progressive language dysfunction.
Paola ePiscopo +4 more
doaj +3 more sources
Genetics of frontotemporal lobar degeneration
Annals of Indian Academy of Neurology, 2010 Frontotemporal lobar degeneration (FTLD) is a highly heterogenous group of progressive neurodegenerative disorders characterized by atrophy of prefrontal and anterior temporal cortices.
Aswathy P, Jairani P, Mathuranath P
doaj +3 more sources
Apathy and impulsivity in frontotemporal lobar degeneration syndromes [PDF]
Brain, 2017 Apathy and impulsivity are common and disabling consequences of frontotemporal lobar degeneration. They cause substantial carer distress, but their aetiology remains elusive.
Coyle-Gilchrist, ITS +8 more
core +5 more sources
Unpicking frontotemporal lobar degeneration [PDF]
Brain, 2011 Not so long ago, frontotemporal lobar degeneration (FTLD) seemed quite simple. Apart from rare variants of Alzheimer's disease and the occasional obscure neurodegenerative disease that could not be classified, FTLD was synonymous with Pick's disease, first described by Arnold Pick (1892) in a series of patients with ‘circumscribed atrophy’ and aphasia.
Love, Seth, Spillantini, Maria Grazia
openaire +3 more sources
Frontotemporal Lobar Degeneration Without Lobar Atrophy [PDF]
Archives of Neurology, 2006 Frontotemporal lobar degeneration with ubiquitin-only-immunoreactive neuronal inclusions (FTLD-U) is the most common form of frontotemporal dementia. Neuronal loss and gliosis in cornu ammonis 1 and the subiculum of the hippocampus are features of hippocampal sclerosis (HpScl), which occurs in many cases of FTLD-U.To determine if there were any ...
Keith A, Josephs +4 more
openaire +2 more sources
Response to: Clinical Imaging Features of Sporadic and Genetic Frontotemporal Lobar Degeneration TDP‐43 A and B [PDF]
Annals of Clinical and Translational NeurologySergi Borrego‐Écija +3 more
doaj +2 more sources
Persistent and Progressive Outer Retina Thinning in Frontotemporal Degeneration
Frontiers in Neuroscience, 2019 ObjectiveWhile Alzheimer’s disease is associated with inner retina thinning measured by spectral-domain optical coherence tomography (SD-OCT), our previous cross-sectional study suggested outer retina thinning in frontotemporal degeneration (FTD ...
Benjamin J. Kim +9 more
doaj +1 more source
A 43-kDa TDP-43 species is present in aggregates associated with frontotemporal lobar degeneration. [PDF]
PLoS ONE, 2013 The transactive response DNA-binding protein (TDP-43) is a major component of the abnormal intracellular inclusions that occur in two common neurodegenerative diseases of humans: (1) a subtype of frontotemporal lobar degeneration and (2) amyotrophic ...
Patrick J Bosque +2 more
doaj +1 more source