Results 31 to 40 of about 23,647 (218)

Clinical, Genetic and Neuropathological Features of Frontotemporal Dementia: An Update and Guide

Acta Médica Portuguesa, 2013
Introduction: Frontotemporal Lobar Degeneration encompasses a group of heterogeneous disorders with shared behavioural and cognitive symptoms, as well as gross pathological features.
Jorge Pelicano Paulos, João Massano
doaj   +1 more source

Hexanucleotide Repeat Expansion in C9ORF72 Is Not Detected in the Treatment-Resistant Schizophrenia Patients of Chinese Han. [PDF]

PLoS ONE, 2015
Hexanucleotide (GGGGCC) repeat expansion in C9ORF72 (HRE) causes frontotemporal lobar degeneration, frontotemporal dementia-amyotrophic lateral sclerosis, and amyotrophic lateral sclerosis.
Xijia Xu, Shiping Xie, Xiaomeng Shi, Jie Lv, Xiaowei Tang, Xiaolan Wang, Shuiping Lu, Mingzhong Wang, Xiaobing Zhang, Jing Sun, Hui Yao   +10 more
doaj   +1 more source

Clinicopathological evaluation of chronic traumatic encephalopathy in players of American football [PDF]

, 2017
IMPORTANCE: Players of American football may be at increased risk of long-term neurological conditions, particularly chronic traumatic encephalopathy (CTE).
Abdolmohammadi, Bobak, Alosco, Michael L., Alvarez, Victor E., Baugh, Christine M., Cantu, Robert C., Chaisson, Christine E., Cormier, Kerry A., Daneshvar, Daniel H., Goldstein, Lee E., Huber, Bertrand R., Katz, Douglas I., Kiernan, Patrick T., Kowall, Neil W., Kubilus, Caroline A., Martin, Brett M., McClean, Michael D., McHale, Lisa, McKee, Ann C., Mez, Jesse, Montenigro, Phillip H., Murphy, Lauren, Nowinski, Christopher J., Solomon, Todd M., Stein, Thor D., Stern, Robert A., Tripodis, Yorghos, Weuve, Jennifer   +26 more
core   +1 more source

Terra incognita—cerebellar contributions to neuropsychiatric and cognitive dysfunction in behavioral variant frontotemporal dementia [PDF]

, 2015
Although converging evidence has positioned the human cerebellum as an important relay for intact cognitive and neuropsychiatric processing, changes in this large structure remain mostly overlooked in behavioral variant frontotemporal dementia (bvFTD), a
Emma eDevenney, Emma eDevenney, Glenda M Halliday, Glenda M Halliday, John R Hodges, John R Hodges, John R Hodges, Matthew C Kiernan, Matthew C Kiernan, Michael eHornberger, Michael eHornberger, Michael eHornberger, Rachel H Tan, Rachel H Tan   +13 more
core   +2 more sources

Validation of the German Revised Addenbrooke's Cognitive Examination for Detecting Mild Cognitive Impairment, Mild Dementia in Alzheimer's Disease and Frontotemporal Lobar Degeneration [PDF]

, 2010
Background/Aims: The diagnostic accuracy of the German version of the revised Addenbrooke's Cognitive Examination (ACE-R) in identifying mild cognitive impairment (MCI), mild dementia in Alzheimer's disease (AD) and mild dementia in frontotemporal lobar ...
Aguilar, C. A., Alexopoulos, P., Danek, Adrian, Diehl-Schmid, J., Ebert, A., Foerstl, H., Gourzis, P., Kneib, T., Kornhuber, J., Kurz, A., Natale, B., Perneczky, R., Richter-Schmidinger, T., Schoell, E., Weih, M.   +14 more
core   +1 more source

Delusions in frontotemporal lobar degeneration [PDF]

Journal of Neurology, 2009
We assessed the significance and nature of delusions in frontotemporal lobar degeneration (FTLD), an important cause of young-onset dementia with prominent neuropsychiatric features that remain incompletely characterised. The case notes of all patients meeting diagnostic criteria for FTLD attending a tertiary level cognitive disorders clinic over a ...
Omar, R., Sampson, E.L., Loy, C.T., Mummery, C.J., Fox, N.C., Rossor, M.N., Warren, J.D.   +6 more
openaire   +4 more sources

Characterization of Movement Disorder Phenomenology in Genetically Proven, Familial Frontotemporal Lobar Degeneration: A Systematic Review and Meta-Analysis.

PLoS ONE, 2016
BackgroundMutations in granulin (PGRN) and tau (MAPT), and hexanucleotide repeat expansions near the C9orf72 genes are the most prevalent genetic causes of frontotemporal lobar degeneration.
Carmen Gasca-Salas, Mario Masellis, Edwin Khoo, Binit B Shah, David Fisman, Anthony E Lang, Galit Kleiner-Fisman   +6 more
doaj   +1 more source

PRNP P39L variant is a rare cause of frontotemporal dementia in Iialian population [PDF]

, 2016
The missense P39L variant in the prion protein gene (PRNP) has recently been associated with frontotemporal dementia (FTD). Here, we analyzed the presence of the P39L variant in 761 patients with FTD and 719 controls and found a single carrier among ...
Arcaro, Marina, Arighi, Andrea, Arosio, Beatrice, Benussi, Luisa, Binetti, Giuliano, Bruno, Giuseppe, Bursey, Devan, Cioffi, Sara Mg, Confaloni, Annamaria, Fenoglio, Chiara, Fumagalli, Giorgio G, Galimberti, Daniela, Ghidoni, Roberta, Grande, Giulia, Kauwe, John S, Mari, Daniela, Mariani, Claudio, Nacmias, Benedetta, Oldoni, Emanuela, Pinessi, Lorenzo, Piscopo, Paola, Rainero, Innocenzo, Rubino, Elisa, Scarioni, Marta, Scarpini, Elio, Serpente, Maria, Sorbi, Sandro, Talarico, Giuseppina   +27 more
core   +2 more sources

Deletion of the progranulin gene in patients with frontotemporal lobar degeneration or Parkinson disease

Neurobiology of Disease, 2008
Progranulin gene (PGRN) mutations cause ubiquitin-positive frontotemporal lobar degeneration linked to chromosome 17 (FTLDU-17). The spectrum of known mutations strongly suggests that neurodegeneration results from a partial loss of PGRN function and ...
Anne Rovelet-Lecrux, Vincent Deramecourt, Solenn Legallic, Claude-Alain Maurage, Isabelle Le Ber, Alexis Brice, Jean-Charles Lambert, Thierry Frébourg, Didier Hannequin, Florence Pasquier, Dominique Campion   +10 more
doaj   +1 more source

Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis

Communications Biology, 2021
Jin et al use dynamic molecular network analysis to characterise the phosphoproteome in mouse models of neurodegenerative disease. Analyzing four models of frontotemporal lobar degeneration and four models of Alzheimer’s disease, they observe conserved ...
Meihua Jin, Xiaocen Jin, Hidenori Homma, Kyota Fujita, Hikari Tanaka, Shigeo Murayama, Hiroyasu Akatsu, Kazuhiko Tagawa, Hitoshi Okazawa   +8 more
doaj   +1 more source