Results 81 to 90 of about 201,352 (177)

Cascaded multimodal deep learning in the differential diagnosis, progression prediction, and staging of Alzheimer's and frontotemporal dementia [PDF]

Dementia syndromes are complex sequelae whose multifaceted nature poses significant challenges in the diagnosis, prognosis, and treatment of patients. Despite the availability of large open-source data fueling a wealth of promising research, effective ...
Valk, S. ; https://orcid.org/, Castellaro, M., Molloy, E., Reinelt, J., Thierbach, K., Ugolini, M., Villringer, A. ; https://orcid.org/, Wu, Q., Scherf, N. ; https://orcid.org/, Mueller, K. ; https://orcid.org/, Guarnier, G., Babayan, A. ; https://orcid.org/, Schroeter, M. ; https://orcid.org/, Mihai, P., Modestino, A., Einaliyan, P.   +15 more
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Frontotemporal dementia in Hispanic populations: Regional and national comparisons

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Although Hispanic/Latine populations experience higher dementia rates, they remain underrepresented in frontotemporal dementia (FTD) research.
Shannon B. Lavigne, Gabrielle Hromas, Ashley LaRoche, Alicia S. Parker, Muhammad S. Abdullah, Roman A. Fernandez, Chen‐Pin Wang, Gabriel deErausquin, Arash Salardini, Jeremy Tanner, Tiffany F. Kautz, Julia Castro, Crystal Mendoza, Sudha Seshadri, A. Campbell Sullivan   +14 more
doaj   +1 more source

Underdiagnosis of frontotemporal lobar degeneration in Brazil

Dementia & Neuropsychologia
Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disorder that involves the frontal and anterior temporal lobes. It is characterized by prominent behavioral and language disorders.
Valéria Santoro Bahia
doaj   +1 more source

Epidemiology of Frontotemporal Lobar Degeneration in Northern Finland

Dementia and Geriatric Cognitive Disorders Extra, 2015
Background: Frontotemporal lobar degeneration (FTLD) is responsible for as many as every fifth case of early-onset dementia. Very few epidemiological studies of FTLD have been conducted; there are no published epidemiological data of FTLD from Finland or
Laura Luukkainen, Risto Bloigu, Virpi Moilanen, Anne Marja Remes   +3 more
doaj   +1 more source

Leukodystrophy in Tanzania: A Case Study Highlighting Diagnostic Dilemmas and Clinical Implications

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Leukodystrophies are rare inherited neurodegenerative disorders characterized by progressive white matter dysfunction and neurological decline. In low‐resource settings, limited access to advanced neuroimaging, biochemical investigations, and genetic testing often delays diagnosis and complicates differentiation from more common infectious ...
William Nkenguye, Mujaheed Suleman, Jay Lodhia   +2 more
wiley   +1 more source

Establishing robust cognitive dimensions for characterization and differentiation of patients with Alzheimer's disease, mild cognitive impairment, frontotemporal dementia and depression [PDF]

, 2014
The diagnosis of mild cognitive impairment (MCI) and dementia requires detailed neuropsychological examinations. These examinations typically yield a large number of outcome variables, which may complicate the interpretation and communication of results.
Beck, Irene R., Andreas U. Monsch, Schmid, Nicole S., Irene R. Beck, Nicole S. Schmid, Manfred Berres, Berres, Manfred, Monsch, Andreas U.   +7 more
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Elevated endogenous glucagon‐like peptide‐1 as a novel Alzheimer's disease biomarker associated with neuroinflammation and Aβ pathology

General Psychiatry, Volume 39, Issue 5, October 2026.
ABSTRACT Background Alzheimer's disease (AD), a neurodegenerative disorder, is pathologically defined by the accumulation of amyloid‐β (Aβ) plaques, hyperphosphorylated tau tangles and sustained neuroinflammation. Glucagon‐like peptide‐1 (GLP‐1), originally characterised as an incretin hormone, is also expressed endogenously in the brain.
Jianping Li, Chenhui Ji, Jintao Wang, Jinwen Xiao, Haixia Li, Xinyi Xie, Nan Zhi, Yaying Song, Wenwei Cao, Liling Wang, Jieli Geng, Rujing Ren, Gang Wang   +12 more
wiley   +1 more source

Frontotemporal dementia is the leading cause of “true” A−/T+ profiles defined with Aβ42/40 ratio

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction Patients with positive tauopathy but negative Aβ42 (A−T+) in the cerebrospinal fluid (CSF) represent a diagnostic challenge. The Aβ42/40 ratio supersedes Aβ42 and reintegrates “false” A−T+ patients into the Alzheimer's disease spectrum ...
Hélène Pouclet‐Courtemanche, Tri‐Bao Nguyen, Emilie Skrobala, Claire Boutoleau‐Bretonnière, Florence Pasquier, Elodie Bouaziz‐Amar, Edith Bigot‐Corbel, Susanna Schraen, Julien Dumurgier, Claire Paquet, Thibaud Lebouvier   +10 more
doaj   +1 more source

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

Poly‐GP in cerebrospinal fluid links C9orf72‐associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD [PDF]

, 2017
The C9orf72 GGGGCC repeat expansion is a major cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). Non‐conventional repeat translation results in five dipeptide repeat proteins (DPRs), but their clinical utility, overall ...
Edbauer, D., Otto, M., Lehmer, C., Fassbender, K., Ludolph, A., Landwehrmeyer, B., Steinacker, P., Schroeter, M.L., Kremmer, E., Diehl-Schmid, J., Schludi, M.H., Ludolph, A.C., Flatley, A., Volk, A., Kornhuber, J., Schludi, M., Arzberger, T., Volk, A.E., Weydt, P., Levin, J., Lauer, M., Weishaupt, J., Weishaupt, J.H., Oeckl, P., Feederle, R., Schroeter, M. ; https://orcid.org/   +25 more
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