Results 81 to 90 of about 23,647 (218)

Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations. [PDF]

, 2019
Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotemporal dementia. Most pathogenic GRN mutations result in progranulin haploinsufficiency, which is thought to cause frontotemporal dementia in GRN mutation ...
Arrant, Andrew E, Boyle, Nicholas R, Grinberg, Lea T, Hoffmann, Madelyn Q, Kashyap, Shreya N, Miller, Bruce L, Murchison, Charles F, Nana, Alissa L, Ramos, Eliana Marisa, Roberson, Erik D, Roth, Jonathan R, Seeley, William W, Spina, Salvatore   +12 more
core  

The clinical spectrum of sporadic and familial forms of frontotemporal dementia [PDF]

, 2016
The term frontotemporal dementia (FTD) describes a clinically, genetically and pathologically diverse group of neurodegenerative disorders. Symptoms of FTD can present in individuals in their twenties through to their nineties, but the mean age at onset ...
Rohrer, JD, Woollacott, IO
core   +1 more source

Data‐driven thresholds for standardized classification of severe Alzheimer's disease neuropathology using digital neuropathology

Brain Pathology, EarlyView.
We generated digital pathologic algorithms (AI‐based modules that can be freely shared) to: optimize the sampling (ROI) for diagnosis of ADNC‐related tau pathology; compare/transition between Aperio and HALO platforms; and rationalize severe Braak NFT staging, so that all Braak‐VI cases had dementia, and all Braak‐V cases had MCI or dementia.
Ryan K. Shahidehpour, Allison M. Neltner, Mitchell A. Klusty, Cole Corbett, Angelique D. Gonzalez, David A. Gutman, David W. Fardo, Adam D. Bachstetter, Cody Bumgardner, Margaret E. Flanagan, Peter T. Nelson   +10 more
wiley   +1 more source

Biomarkers in frontotemporal lobar degeneration [PDF]

Current Opinion in Neurology, 2010
Recent findings assessing the utility of neuroimaging and biofluid biomarkers are reviewed that help identify patients with frontotemporal lobar degeneration (FTLD) spectrum abnormality.Neuroimaging studies using T1 structural MRI and diffusion tensor imaging (DTI) distinguish between patients with FTLD and Alzheimer's disease, although the reliability
openaire   +2 more sources

Is this a new type of primary prosopagnosia, both progressive and apperceptive?

Neuropsychiatric Disease and Treatment, 2012
Azusa Sugimoto1, Shinichi Koyama2, Akira Midorikawa3, Akinori Futamura1, Kiichi Ishiwata4, Kenji Ishii4, Michael W Miller5, Mitsuru Kawamura11Department of Neurology, Showa University School of Medicine, Tokyo, 2Design Psychology Unit, Department of ...
Sugimoto A, Koyama S, Midorikawa A, Futamura A, Ishiwata K, Ishii K, Miller MW, Kawamura M   +7 more
doaj  

Underdiagnosis of frontotemporal lobar degeneration in Brazil

Dementia & Neuropsychologia
Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disorder that involves the frontal and anterior temporal lobes. It is characterized by prominent behavioral and language disorders.
Valéria Santoro Bahia
doaj   +1 more source

Epidemiology of Frontotemporal Lobar Degeneration in Northern Finland

Dementia and Geriatric Cognitive Disorders Extra, 2015
Background: Frontotemporal lobar degeneration (FTLD) is responsible for as many as every fifth case of early-onset dementia. Very few epidemiological studies of FTLD have been conducted; there are no published epidemiological data of FTLD from Finland or
Laura Luukkainen, Risto Bloigu, Virpi Moilanen, Anne Marja Remes   +3 more
doaj   +1 more source

Combined Imaging Markers Dissociate Alzheimer's Disease and Frontotemporal Lobar Degeneration – An ALE Meta-Analysis [PDF]

, 2011
To compare and dissociate the neural correlates of Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD), we combine and synthesize here recent comprehensive meta-analyses.
Matthias L. Schroeter, Jane Neumann
core   +2 more sources

Mini social cognition and emotional assessment: Diagnostic performance and neural correlates in behavioural‐variant frontotemporal dementia

Journal of Neuropsychology, EarlyView.
Abstract We aimed at validating the Mini Social Cognition and Emotional Assessment (Mini‐SEA) in a German cohort of mildly impaired behavioural‐variant frontotemporal dementia (bvFTD) patients and healthy controls. The Mini‐SEA comprises the Facial Emotion Recognition Test (FERT) and the Faux Pas Test (FPT) measuring Theory of Mind (ToM) abilities in ...
Cem Doğdu, Neeraj Upadhyay, Ingo Frommann, Luca Kleineidam, Andreas Johnen, Melina Stark, Sandra Roeske, Annika Spottke, Anna Gamez, Gabor C. Petzold, Louise Droste zu Senden, Julian Hellmann‐Regen, Stefan Hetzer, Klaus Fliessbach, Carolin Miklitz, Emrah Düzel, Falk Lüsebrink, Wenzel Glanz, Stefan Teipel, Ingo Kilimann, Josef Priller, Eike Jakob Spruth, Johannes Prudlo, David Mengel, Klaus Scheffler, Matthis Synofzik, Anja Schneider, Michael Wagner   +27 more
wiley   +1 more source

Frontotemporal dementia is the leading cause of “true” A−/T+ profiles defined with Aβ42/40 ratio

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction Patients with positive tauopathy but negative Aβ42 (A−T+) in the cerebrospinal fluid (CSF) represent a diagnostic challenge. The Aβ42/40 ratio supersedes Aβ42 and reintegrates “false” A−T+ patients into the Alzheimer's disease spectrum ...
Hélène Pouclet‐Courtemanche, Tri‐Bao Nguyen, Emilie Skrobala, Claire Boutoleau‐Bretonnière, Florence Pasquier, Elodie Bouaziz‐Amar, Edith Bigot‐Corbel, Susanna Schraen, Julien Dumurgier, Claire Paquet, Thibaud Lebouvier   +10 more
doaj   +1 more source