Results 31 to 40 of about 128,601 (309)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Activation of NPY2R-expressing amygdala neurons inhibits itch behavior in mice without lateralization

open access: yesScientific Reports
The central amygdala (CeA) is a crucial hub in the processing of affective itch, containing a diverse array of neuronal populations. Among these components, Neuropeptide Y (NPY) and its receptors, such as NPY2R, affect various physiological and ...
Darya Pavlenko   +7 more
doaj   +1 more source

Melanoma on Chronically Sun-Damaged Skin: Deciphering Gene Expression Signatures

open access: yesDermatology Practical & Conceptual
Introduction: Melanoma of the skin is responsible for most skin cancer-related deaths. It is well known that exposure to ultraviolet radiation is the most common and modifiable risk factor for melanoma.  Melanomas arising on chronically sun-damaged skin
Alejandra Avila   +9 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Secondary frost heave in freezing soils

open access: yes, 1996
Frost heave describes the phenomenon whereby soil freezing causes upwards surface motion due to the action of capillary suction imbibing water from the unfrozen region below. The expansion of water on freezing is a small part of the overall surface heave
Noon, C.
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Frost Preparatory Program Advanced Piano Program Master Class

open access: yes, 2023
Dr. Roberta Rust, acclaimed musician and Artist Faculty, Professor and head of the piano department at the Lynn University Conservatory of Music, teaches a master class to the Frost Prep Advanced Piano Program students at the Frost School of Music at the
Rust, Roberta
core  

On the frost resistance of red clover with special attention to seed production

open access: yesAgricultural and Food Science, 1966
The frost-resistance of Finnish red clover has been studied by means of experiments in a cold cabinet and on the basis of samples taken from the field.
Arvi Valmari, Irja Valmari
doaj  

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