Results 111 to 120 of about 232,959 (351)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Performance of a hypersonic hot fuselage structure with a carbon dioxide frost projected, nonintegral cryogenic tank [PDF]

open access: yes
A model which consisted of a hot structure and a nonintegral tank protected by a carbon dioxide frost thermal protection system was tested under the following conditions: (1) room temperature loading and (2) heating and loading corresponding to the Mach ...
Jackson, L. R., Sharpe, E. L.
core   +1 more source

Temperature calculation of soil foundation in geotechnical software packages

open access: yesАрхитектура, строительство, транспорт
A crucial step in addressing the challenge of constructing shallow foundations on seasonally freezing heaving soils is performing temperature calculations of the soil foundation.
D. S. Skvortsov   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Design study of an entry probe spectro-reflectometer [PDF]

open access: yes
A wind tunnel was built to simulate the rapid movement of an entry probe through the Jupiter atmosphere. Wind speeds range from 1 to 50 meters per second in a closed system.
Fink, U., Sill, G. T.
core   +1 more source

Home - About - Disclaimer - Privacy