Results 121 to 130 of about 232,959 (351)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Results of the Mariner 6 and 7 Mars occultation experiments [PDF]

Final profiles of temperature, pressure, and electron density on Mars were obtained for the Mariner 6 and 7 entry and exit cases, and results are presented for both the lower atmosphere and ionosphere.
Hogan, J. S., Rasool, S. I., Russell, L. H., Stewart, R. W.   +3 more
core   +1 more source

Frost modelling and pavement temperatures : summer pavement temperatures and frost modelling: licentiate thesis

, 2001
Temperatur och fuktighet är mycket väsentliga parametrar vid beskrivning av tillståndet i en vägkropp. Hög fuktighet innebär oftast nedsatt bärighet med kortare livslängd för konstruktionen som följd. En frusen vägkropp har större bärighet än motsvarande konstruktion under vår eller sen höst.
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Thermal modeling of Anchorage driveway culvert with addition of insulation to prevent frost heaving [PDF]

, 2017
A predominate problem in cold regions, and specifically in Anchorage, Alaska, is frost heaving pavement above culverts in residential driveways. The culvert increases heat loss in the subgrade materials during winter months and allows the soils below ...
Banzhaf, Clinton J.
core  

Temperatures and frost damage: Measurements of temperature inversions and blossom counts show extent of frost damage in tests in deciduous orchards

California Agriculture, 1956
The effectiveness of all frost protection depends primarily on the temperature inversion—ceiling—but adequate measurements had not been made until an extensive field program was undertaken in northern California in the spring of 1956. Six thermographs equipped with 50' extensions were installed with other spot-climate recording stations in selected ...
F Brooks, A Leonard
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Resilient Modulus Characterization of Alaskan Granular Base Materials [PDF]

, 2010
INE/AUC 11 ...
Li, Lin, Liu, Juanyu, Zhang, Xiong
core