Results 61 to 70 of about 803 (166)

Targeting Ferroptosis With Natural Products for the Treatment of Skeletal System Disease: An Updated Review

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Skeletal system diseases, encompassing chronic disorders of the skeletal system which commonly include osteoarthritis, rheumatoid arthritis, osteoporosis and osteosarcoma. Their incidence rates have been increasing in recent years, resulting in significant social and economic burdens.
Qian Yi, Jinye Li, Guotian Luo, Jiachen Li, Dahang Yang, Wei Sun, Weichao Sun, Wei You, Lei Yang   +8 more
wiley   +1 more source

AIE‐Mediated In Situ Monitoring of Protein Aggregates During Coagulation and Screening of Anticoagulant Agents

Aggregate, Volume 7, Issue 1, January 2026.
The process of screening active monomers via BioSTAS technology. (A) Analyzing the properties and luminescence mechanism of an AIE molecule through density functional theory and MD simulation. (B) The establishment of a screening model, including biosensing and affinity chromatography. (C) Screening and identification of active substances.
Shuxian Zhang, Hui Yuan, Lingling Yang, Xiaoxuan Fan, Keshuai Liu, Rui Mai, Wangyan Zhao, Cheng Liu, Qiang Han, Yongjian Ai, Qionglin Liang, Xueqin Ma, Guoning Chen   +12 more
wiley   +1 more source

Metabolomics combined with proteomics analysis of femur provides a comprehensive interpretation of the changes in postmenopausal osteoporosis under salidroside treatment

Pharmacological Research - Modern Chinese Medicine, 2022
Ethnopharmacological relevance: Salidroside (SA), a primary biologically active compound in Fructus Ligustri Lucidi, has a definite effect on anti-aging, a physiological phenomenon that is directly related to postmenopausal osteoporosis (PMOP).
Yuanyuan Zhai, Xin Li, Yifei Wang, Mengting Gao, Li Feng, Jinjun Shan, Tong Xie, Yudan Cao, Fangfang Cheng, Beihua Bao, Li Zhang, Anwei Ding, Zhipeng Li, Weifeng Yao   +13 more
doaj   +1 more source

Comparative analysis of the influence of Fructus Ligustri Lucidi on a rat lumbar disc herniation model

Molecular Medicine Reports, 2012
Lumbar disc herniation (LDH) is a term used for a group of conditions, including back pain, femoral nerve pain and sciatica. Currently available treatments and surgical options are insufficient for patients with LDH. Fructus Ligustri Lucidi (FLL) is a herb that is used for treating age-associated diseases.
Ya-Xin, Han, Dong, Liang, Xiao-Rui, Han, De-Yong, Liang   +3 more
openaire   +3 more sources

Chinese Herbal Medicines for Diabetic Cardio‐Cerebrovascular Diseases: Key Bioactive Metabolites and Action Mechanisms

Journal of Nutrition and Metabolism, Volume 2026, Issue 1, 2026.
Currently, the global incidence of diabetes is increasing, particularly in populous developing regions. In China, over 290 million people are affected by diabetic cardio‐cerebrovascular diseases. These diseases account for more than 40% of deaths and impose a significant economic burden on both society and families.
Ying Su, Shuwen Luo, Wei Li, Cuicui Cheng, Wei Liu, Xinyu Yang, Zhen Xing, Eric Gumpricht   +7 more
wiley   +1 more source

Herbal Treatment for Osteoporosis: A Current Review

Journal of Traditional and Complementary Medicine, 2013
Osteoporosis is an aging problem. The declining bone mineral density (BMD) enhances the chances of fractures during minor falls. Effective pharmaceuticals are available for a rapid improvement of BMD.
Ping-Chung Leung, Wing-Sum Siu
doaj   +1 more source

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, Volume 58, Issue 10, October 2025.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

Jian Pi Hua Tan Fang Reverses Trastuzumab Resistance of HER2‐Positive Gastric Cancer Through PI3K/AKT/mTOR Pathway: Integrating Network Pharmacology, Molecular Docking and Experimental Validation

Immunity, Inflammation and Disease, Volume 13, Issue 2, February 2025.
Research methods of network pharmacology and molecular docking binding. Experimental validation was combined with network pharmacological analysis. In vitro study of NCI‐N87/TR cells in rat serum containing JPHTF. JPHTF reverses trastuzumab resistance in HER2‐positive GC through PI3K/AKT/mTOR pathway.
Jia Hu, Wenjing Bu, Yongfang Ding, Xin Li, Bo Zhang, Bo Shen, Cong Wu, Youqi Xu, Xiaoyang Zhang   +8 more
wiley   +1 more source

Fructus Ligustri Lucidi ethanol extract inhibits osteoclastogenesis in RAW264.7 cells via the RANKL signaling pathway

, 2016
Fructus ligustri Lucidi (FLL) is the fruit of Ligustrum lucidum Ait and a traditional Chinese medicine, primarily known for its role in osteoporosis prevention and treatment.
Xu, Dan, Zhu, Xiaoyu, Feng, Jinqiu, Xu, Yajun, Chen, Xiaowen, Lyu, Ying   +5 more
core   +1 more source

Neuroprotective Effect of Fructus Ligustri Lucidi in Spinal Cord Neuron Injury during H2O2‐Mediated Oxidative Stress

Journal of Food Biochemistry, Volume 2024, Issue 1, 2024.
Oxidative stress‐induced neuronal damage is a significant factor contributing to spinal cord injury. Although previous research has shown that Fructus Ligustri Lucidi (FLL) has neuroprotective benefits in SH‐SY5Y, BV2, and PC12 cells, its impact on primary spinal cord neurons, which more accurately reflect the characteristics of central nervous system ...
Junseon Lee, Hyunseong Kim, Wan-Jin Jeon, Changhwan Yeo, Hyun Kim, Jin Young Hong, Seung Ho Baek, Yoon Jae Lee, In-Hyuk Ha, Jae Young Je   +9 more
wiley   +1 more source