Results 1 to 10 of about 39 (31)

How to Start a Food Business: Writing a Business Plan [PDF]

EDIS, 2014
Before starting a new food business, you should set a goal and have detailed plans to accomplish that goal. But writing a good business plan is often a challenge and it requires a great amount of effort.
Soohyoun Ahn, Lisa House, Renée Goodrich-Schneider   +2 more
doaj   +7 more sources

Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors : toward the development of novel therapies for African sleeping sickness [PDF]

, 2010
Trypanosoma brucei, the causative agent of human African trypanosomiasis, affects tens of thousands of sub-Saharan Africans. As current therapeutics are inadequate due to toxic side effects, drug resistance, and limited effectiveness, novel therapies are
Michael A. J. Ferguson, Durrant, Jacob D., Ferguson, Michael A. J., Jacob D. Durrant, Ferguson, Michael A. J.; id_orcid, Michael D. Urbaniak, McCammon, J. Andrew, Urbaniak, Michael D., J. Andrew McCammon   +8 more
core   +5 more sources

Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparum [PDF]

, 2012
Isothermal microcalorimetry is an established tool to measure heat flow of physical, chemical or biological processes. The metabolism of viable cells produces heat, and if sufficient cells are present, their heat production can be assessed by this method.
Sergio Wittlin, Trampuz Andrej, Brun, R., Andrej Trampuz, Brun Reto, Wenzler Tanja, Wenzler, T., Christian Scheurer, Scheurer Christian, Scheurer, C., Trampuz, A., Wittlin Sergio, Andrea Steinhuber, Tanja Wenzler, Reto Brun, Steinhuber Andrea, Steinhuber, A., Wittlin, S.   +17 more
core   +2 more sources

Natural and semisynthetic analogues of manadoperoxide B reveal new structural requirements for trypanocidal activity [PDF]

, 2013
Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3).
Calcinai, Barbara, Orazio Taglialatela Scafati, Henny A. Dien, Henny Dien, Dien, Henny, C. Cerrano, TAGLIALATELA SCAFATI, ORAZIO, Fernando Scala, Taglialatela-Scafati, Orazio, Kaiser, Marcel, M. Kaiser, Tasdemir, Deniz, Marcel Kaiser, Carlo Cerrano, Chianese, Giuseppina, Dien, Henny A., B. Calcinai, Deniz Tasdemir, D. Tasdemir, Scala, Fernando, Barbara Calcinai, Giuseppina Chianese, H. A. Dien, Orazio Taglialatela-Scafati, Cerrano, Carlo   +24 more
core   +1 more source

Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation [PDF]

, 2011
Background: The essential purine salvage pathway of Trypanosoma brucei bears interesting catalytic enzymes for chemotherapeutic intervention of Human African Trypanosomiasis.
Jason Greenwald, Perozzo Remo, Greenwald Jason, Dirk Kostrewa, Leonardo Scapozza, Remo Perozzo, Kuettel Sabine, Perozzo, Remo, Shaheen Ahmed, Kostrewa Dirk, Scapozza Leonardo, Kuettel, Sabine, Greenwald, Jason, Scapozza, Leonardo, Ahmed Shaheen, Kostrewa, Dirk, Sabine Kuettel, Ahmed, Shaheen   +17 more
core   +2 more sources

Invasive plants as catalysts for the spread of human parasites [PDF]

, 2011
To a degree not widely recognized, some naturalized and invasive plants increase the risks to human health by enhancing the proliferation of vectors of virulent human parasites. These potential risks are restricted by neither ecosystem nor geography. The
Mack, Richard N., Mack, Richard, Smith,Melissa, Melissa Smith, Richard Mack, Mack,Richard, Smith, Melissa C., Smith, Melissa   +7 more
core   +1 more source

Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent Trypanocidal compounds [PDF]

, 2010
RNAi and enzymatic studies have shown the importance of 6-phosphogluconate dehydrogenase (6-PGDH) in Trypanosoma brucei for the parasite survival and make it an attractive drug target for the development of new treatments against human African ...
Ruda, Gian Filippo, Norval, S., Read, Kevin D., Gian Filippo Ruda, Barrett, M.P., Michael P. Barrett, Norval, Suzanne, Pui Ee Wong, Vincent P. Alibu, Wong, P.E., Kevin D. Read, Suzanne Norval, Ian H. Gilbert, Alibu, V.P., Gilbert, I.H., Gilbert, Ian H., Read, K.D., Alibu, Vincent P., Barrett, Michael P., Ruda, G.F., Wong, Pui Ee   +20 more
core   +1 more source

Efficacy and safety of pafuramidine versus pentamidine maleate for treatment of first stage sleeping sickness in a randomized, comparator-controlled, international phase 3 clinical trial [PDF]

, 2016
Sleeping sickness (human African trypanosomiasis [HAT]) is a neglected tropical disease with limited treatment options that currently require parenteral administration.
Carol A. Olson (1807531), Mintwo, Alain Fukinsia, Deo, Gratias Kambau Manesa, Sonja C. Bernhard, Bilenge, Constantin Miaka Mia, Patrick Mangoni N'tombe, Pierre Nsele Mutantu (1807651), Gabriele Pohlig, Patrick Mangoni N’tombe (1807627), Sonja C Bernhard, Alain Fukinsia Mintwo, N'tombe, Patrick Mangoni, N’tombe, Patrick Mangoni, Stephen Macharia (1807624), Kuikumbi, Florent Mbo, Mpanya, Alain, Richard R. Tidwell, Alain Mpanya, Augustin Kayeye Munungi, Blum, Johannes, Gratias Kambau Manesa Deo, Alain Fukinsia Mintwo (1807636), Gabriele Pohlig, Richard R Tidwell, Pierre Nsele Mutantu, Constantin Miaka Mia Bilenge, Gratias Kambau Manesa Deo (1807630), Patrick Mangoni N’tombe, Alfred Mpoo Mpoto, Bernhard, Sonja C., Augustin Kayeye Munungi (1807645), Tidwell, Richard R., Christian Burri (141244), Carol A Olson, Ndinga Dieyi Dituvanga, Sonja C. Bernhard (1807537), Ndinga Dieyi Dituvanga (1807648), Blaise Fungula Munungu, Burri, Christian, Munungu, Blaise Fungula, Olson, Carol A., Macharia, Stephen, Dituvanga, Ndinga Dieyi, Victor Kande Betu Ku Mesu, Constantin Miaka Mia Bilenge (1807513), Blaise Fungula Munungu (1807519), Mpoto, Alfred Mpoo, Christian Burri, Jose Ramon Franco, Jean-Pierre Fina Lubaki (1807546), Mutantu, Pierre Nsele, Franco, Jose Ramon, Johannes Blum, Lubaki, Jean-Pierre Fina, Gabriele Pohlig (267149), Pohlig, Gabriele, Jose Ramon Franco (1807639), Carol A. Olson, Mesu, Victor Kande Betu Ku, Alfred Mpoo Mpoto (1807534), Stephen Macharia, Alain Mpanya (267142), Amadeu Dala, Johannes Blum (141240), Dala, Amadeu, Munungi, Augustin Kayeye, Victor Kande Betu Ku Mesu (1807510), Florent Mbo Kuikumbi (1807633), Amadeu Dala (1807642), Richard R. Tidwell (148409), Florent Mbo Kuikumbi, Jean-Pierre Fina Lubaki   +71 more
core   +1 more source

Efficacy, safety, and dose of Pafuramidine, a new oral drug for treatment of first stage sleeping sickness, in a phase 2a clinical study and phase 2b randomized clinical studies [PDF]

, 2016
Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death.
Carol A. Olson (1807531), Patrick D Yeramian, Bilenge, Constantin Miaka Mia, Pascal Lutumba, Manuel, F, Sonja C Bernhard, Allen, James L., Mpanya, Alain, Alain Mpanya, Blum, Johannes, Lubaki, J P, Richard R Tidwell, Gabriele Pohlig, Constantin Miaka Mia Bilenge, Yeramian, Patrick D., Kazadi Kyanza Serge, Tidwell, R R, Thompson, Mark, Alfred Mpoo Mpoto, Bernhard, Sonja C., Tidwell, Richard R., Christian Burri (141244), Carol A Olson, Sonja C. Bernhard (1807537), Blaise Fungula Munungu, Bernhard, S C, James L Allen, Burri, Christian, Munungu, Blaise Fungula, Olson, Carol A., Francisco Manuel (1807528), Victor Kande Betu Ku Mesu, Constantin Miaka Mia Bilenge (1807513), Lutumba, P, Pohlig, G, Mark Thompson, Francisco Manuel, Blaise Fungula Munungu (1807519), Merolle, Ada, Lutumba, Pascal, Ada Merolle, Mpoto, Alfred Mpoo, Mesu, V K, Christian Burri, Jean-Pierre Fina Lubaki (1807546), Allen, J L, Josenando, Théophilo, Ada Merolle (1807540), Johannes Blum, Josenando, T, Lubaki, Jean-Pierre Fina, Gabriele Pohlig (267149), Pohlig, Gabriele, Bilenge, C M, Blum, J, Manuel, Francisco, Merolle, A, Mesu, Victor Kande Betu Ku, Yeramian, P D, Alfred Mpoo Mpoto (1807534), Serge, K K, Munungu, B F, Alain Mpanya (267142), Mark Thompson (533940), James L. Allen (1807522), Olson, C A, Johannes Blum (141240), Mpoto, A M, Victor Kande Betu Ku Mesu (1807510), Théophilo Josenando (1807516), Mpanya, A, Thompson, M, Patrick D. Yeramian (1807543), Richard R. Tidwell (148409), Théophilo Josenando, Burri, C, Jean-Pierre Fina Lubaki, Serge, Kazadi Kyanza, Kazadi Kyanza Serge (1807525), Pascal Lutumba (116142)   +79 more
core   +2 more sources

Chemotherapy of second stage human African trypanosomiasis : comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys [PDF]

, 2015
Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central nervous system [CNS]) of ...
Wang, Michael Z., Shelley Ching, Bridges, Arlene S., Bridges, Arlene S, Wang, Michael Z, Gem, Charles O, Michael Z Wang, Wolf, Kristina K, Wang, Michael Zhuo, Wolf, Kristina K., Ching, Shelley, Mutuku, James N., Arlene S Bridges, Boykin, David W, Murilla, Grace A, Murilla, Grace A., Qiang Liu, Paine, Mary F., Boykin, David W., Grace A Murilla, Jones, Susan K, Charles O Gem, James N Mutuku, Mary F Paine, Susan K Jones, Richard R Tidwell, Mutuku, James N, Paine, Mary F, David W Boykin, Liu, Qiang, Tidwell, Richard R., John K Thuita, Gem, Charles O., Kristina K Wolf, Jones, Susan K., Brun, Reto, Thuita, John K., Boykin, David, Reto Brun, Piane, Mary F., Tidwell, Richard R, Thuita, John K   +41 more
core   +2 more sources