Results 61 to 70 of about 49,918 (245)

AORTIC PULSE WAVE VELOCITY AS ADDITIONAL PROGNOSTIC CRITERIA IN ABDOMINAL OBESITY

Кардиоваскулярная терапия и профилактика, 2015
Aim. To evaluate the opportunities for application of pulse wave velocity measurements (PWV) in aorta as prediction instrument as additional method in cardiovascular risk (CVR) stratification in patients with abdominal obesity (AO).Material and methods ...
M. A. Druzhilov, O. Yu. Druzhilova, V. V. Otmakhov, T. Yu. Kuznetsova   +3 more
doaj   +1 more source

Lipid‐Facilitated Opening of the ADAM10 Sheddase Revealed by Enhanced Sampling Simulations

Advanced Science, EarlyView.
Phosphatidylserine acts as a lipid trigger to enhance activation of the sheddase ADAM10. By integrating fluorescence spectroscopy assays with enhanced sampling molecular dynamics simulations, this study shows that phosphatidylserine promotes ADAM10 catalytic activity along with expansion of its extracellular domains, enhancing accessibility to scaffold
Adrien Schahl, Nandan Haloi, Marta Carroni, Shengpan Zhang, Quentin James Sattentau, Erdinc Sezgin, Lucie Delemotte, Rebecca J. Howard   +7 more
wiley   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

La didascalia, olvidada función esencial de la Iglesia

Revista de Educación Religiosa, 2019
Para demostrar que la didascalia o educación de cristianos es olvidada función esencial de la Iglesia en la normativa pastoral actual, se tratan los temas siguientes: 1) Minusvaloración de la función educativa de la Iglesia en la normativa pastoral ...
Enrique García Ahumada, fsc
doaj   +1 more source

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Hermanos de La Salle destacados en Chile en la educación de la fe

Revista de Educación Religiosa, 2019
Los Hermanos de las Escuelas Cristianas llegaron en 1877 a Chile como misioneros mediante la educación. Se califican en catequesis, no exclusivamente, porque forman a la vida cristiana con todos los medios de la escuela.
Enrique García Ahumada, fsc
doaj   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Đánh giá tác động của trồng rừng theo tiêu chuẩn của hội đồng quản lý rừng (FSC) đến hiệu quả kinh tế của rừng trồng tại Việt Nam

Tạp chí Khoa học Đại học Cần Thơ
Nghiên cứu được thực hiện nhằm đánh giá tác động việc trồng rừng theo tiêu chuẩn của hội đồng quản lý rừng (FSC) đến hiệu quả kinh tế của các hộ trồng rừng tại 04 huyện Yên Sơn thuộc tỉnh Tuyên Quang, huyện Lương Sơn thuộc tỉnh Hòa Bình, huyện Thạch ...
Trương Quang Hoàng, Hồ Lê Phi Khanh   +1 more
doaj   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source