Results 11 to 20 of about 1,747 (196)

Thiophene-Based Ligands: Design, Synthesis and Their Utilization for Optical Assignment of Polymorphic-Disease-Associated Protein Aggregates. [PDF]

Chembiochem, 2023
Conformation‐sensitive thiophene‐based ligands have emerged as a class of molecular tools for efficient optical imaging of disease‐associated protein aggregates. This review summarizes the design and chemical evolution of thiophene‐based ligands, as well as describes how this class of ligands has been used for fluorescent assignment of polymorphic ...
Björk L, Klingstedt T, Nilsson KPR.
europepmc   +2 more sources

Thiophene-Based Ligands for Histological Multiplex Spectral Detection of Distinct Protein Aggregates in Alzheimer's Disease. [PDF]

Chemistry, 2023
Multiple colors. A palette of fluorescent donor‐acceptor‐donor thiophene‐based ligands with distinct photo‐physical properties was synthesized. Ligands with specific chemical composition displayed selectivity towards distinct protein aggregates in tissue sections with Alzheimer's disease pathology and by applying different combination of ligands ...
Lantz L, Shirani H, Ghetti B, Vidal R, Klingstedt T, Nilsson KPR.   +5 more
europepmc   +2 more sources

The Uppsala APP Mutation Promotes Wild-Type Amyloid-β Aggregation and Deposition In Vivo. [PDF]

Adv Sci (Weinh)
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Ge J, Pagnon de la Vega M, Zampar S, Cerilli E, Koutarapu S, Wu L, Fraser P, Arkan S, Giedraitis V, Lannfelt L, Hultqvist G, Syvänen S, Ingelsson M, Hanrieder J, Sehlin D.   +14 more
europepmc   +2 more sources

Finnish Tattooists Express Concerns Over New REACH‐Compliant Tattoo Inks

JEADV Clinical Practice
JEADV Clinical Practice, Volume 4, Issue 4, Page 890-891, September 2025.
Nicolas Kluger, Jenni Kiiski, Laura Koski   +2 more
doaj   +2 more sources

Structural Properties Dictating Selective Optotracer Detection of Staphylococcus aureus. [PDF]

Chembiochem, 2022
Optotracers are conformation‐sensitive fluorescent tracer molecules that detect peptide‐ and carbohydrate‐based biopolymers. In this study, we investigated the structural properties providing optimal detection of Staphylococcus aureus. We show that the chemical structure and photophysics of these molecules are key tunable characteristics in the ...
Butina K, Lantz L, Choong FX, Tomac A, Shirani H, Löffler S, Nilsson KPR, Richter-Dahlfors A.   +7 more
europepmc   +2 more sources

ConvCGP: A convolutional neural network to predict genetic values of agronomic traits from compressed genome-wide polymorphisms. [PDF]

Plant Genome
Abstract The growing size of genome‐wide polymorphism data in animal and plant breeding has raised concerns regarding computational load and time, particularly when predicting genetic values for target traits using genomic prediction. Several deep learning and conventional methods, including dimensionality reduction techniques such as principal ...
Raihan T, Kim CH, Shimono H, Kimura A, Iwata H.   +4 more
europepmc   +2 more sources

Chemical traits of cerebral amyloid angiopathy in familial British-, Danish-, and non-Alzheimer's dementias. [PDF]

J Neurochem, 2022
MALDI mass spectrometry imaging, a novel biochemical imaging technique, was used to elucidate the differential aggregation pattern of amyloid peptide species in vascular deposits in familial British and Danish dementia (FBD/FDD). Cover Image for this issue: https://doi.org/10.1111/jnc.15424 Abstract Familial British dementia (FBD) and familial Danish ...
Michno W, Koutarapu S, Camacho R, Toomey C, Stringer K, Minta K, Ge J, Jha D, Fernandez-Rodriguez J, Brinkmalm G, Zetterberg H, Blennow K, Ryan NS, Lashley T, Hanrieder J.   +14 more
europepmc   +2 more sources

Electricity Services in the GATS and the FTAA

Energy Studies Review, 2004
International trade agreements are reshaping economies around the world by allowing freer flow of investments, goods and services. Energy and electricity products have the particular characteristic of ranging over both good and service classifications.
Pineau, Pierre-Olivier
openaire   +3 more sources

Cardiac genetic counseling services: Exploring downstream revenue in a pediatric medical center. [PDF]

J Genet Couns
Abstract Genetic counseling is an important component of pediatric cardiac care. The financial costs and benefits of this care have yet to be defined in the literature. Downstream revenue (DSR) analysis can be used to assess the economic impact of genetic counselors (GCs) at their institution beyond the initial patient contact.
Olson M, Anderson J, Knapke S, Kushner A, Martin L, Statile C, Shikany A, Miller EM.   +7 more
europepmc   +2 more sources

Distinct Heterocyclic Moieties Govern the Selectivity of Thiophene‐Vinylene‐Based Ligands towards Aβ or Tau Pathology in Alzheimer's Disease

European Journal of Organic Chemistry, Volume 26, Issue 41, November 2, 2023., 2023
Tau be or not tau be. A variety of fluorescent thiophene‐vinylene‐based ligands was synthesized. Ligands with specific chemical composition displayed selectivity towards distinct protein aggregates in tissue sections with Alzheimer's disease pathology and distinct heterocyclic moieties governed the selectivity of the ligand towards Aβ or tau pathology.
Linnea Björk, Hamid Shirani, Yogesh Todarwal, Mathieu Linares, Ruben Vidal, Bernardino Ghetti, Patrick Norman, Therése Klingstedt, K. Peter R. Nilsson   +8 more
wiley   +1 more source