Results 21 to 30 of about 8,915 (211)

Structural amyloid plaque polymorphism is associated with distinct lipid accumulations revealed by trapped ion mobility mass spectrometry imaging

Journal of Neurochemistry, Volume 160, Issue 4, Page 482-498, February 2022., 2022
Lipid species have long been implicated in Alzheimer’s disease pathology and beta‐amyloid (Aβ) plaque formation. Using trapped ion mobility spectrometry‐based mass spectrometry imaging (TIMS MSI) allowed us to resolve and unambiguously identify isobaric lipid species in situ that showed distinct localization patterns towards Aβ plaques.
Wojciech Michno, Patrick M. Wehrli, Srinivas Koutarapu, Christian Marsching, Karolina Minta, Junyue Ge, Sven W. Meyer, Henrik Zetterberg, Kaj Blennow, Corinna Henkel, Janina Oetjen, Carsten Hopf, Jörg Hanrieder   +12 more
wiley   +1 more source

Opportunities and Challenges: The Caribbean Involvement in the Free Trade Area of the Americas [PDF]

, 2003
This Article will examine the region\u27s participation in the process leading to the establishment of the FTAA, and the benefits and challenges associated with its involvement in this hemispheric undertaking.
Bishop, Myrtle D., Chandler, Samuel J.
core   +4 more sources

A Free Trade Area of the Americas: Status of Negotiations and Major Policy Issues [PDF]

, 2002
At the second Summit of the Americas in Santiago, Chile (April 1998), 34 Western Hemisphere nations agreed to initiate formal negotiations to create a Free Trade Area of the Americas (FTAA) by 2005.
Hornbeck, J. F.
core   +19 more sources

The Contribution of Entomological Surveillance to the Control of Chagas Disease in Endemic Regions: An Integrative Literature Review

Tropical Medicine &International Health, EarlyView.
ABSTRACT Chagas disease remains a significant public health challenge in various endemic regions of Latin America. The persistence of vector‐borne transmission highlights the complexity of the issue and the limitations of traditional strategies. In this context, entomological surveillance plays a strategic and multifaceted role, not only in the early ...
Daniel Rodrigo de Lima Gomes, Gilliard do Nascimento, Pedro Mariano da Silva Rodrigues, Ana Beatriz da Silva, Ysabele Yngrydh Valente Silva, Ekarinny Myrela Brito de Medeiros, Cléber de Mesquita Andrade, Thales Allyrio Araújo de Medeiros Fernandes, José Antonio da Silva Júnior, Ellany Gurgel Cosme do Nascimento   +9 more
wiley   +1 more source

El TLCAN y más allá de el: Retos en el libre comercio

Fórum Empresarial, 2004
El Tratado de Libre Comercio de Norte América (ALCA) parece haber logrado sus objetivos sin planes adicionales para continuar negociando otras provisiones para el tratado. Sin embargo, con la intención de seguir avanzando el comercio de Norte América, el
Maritza Soto
doaj   +1 more source

The Fluorescent Amyloid Ligand X34 Binding to Transthyretin (TTR) Tetramer and Fibrils: FRET and Binding Constants of a Sequential Two‐step Process

ChemPhotoChem, Volume 9, Issue 2, February 2025.
A secret of life is molecular recognition; the ability of one molecule to recognize another through weak bonding interactions. Here we investigate a fluorescent amyloid ligand X34 and its binding propensity to two apparently asymmetric binding sites of the amyloidogenic plasma protein transthyretin (TTR), both in its native tetrameric form and as an ...
Marikken Sundnes, Priyanka Swaminathan, Mikael Lindgren, Ganesh Mohite, Ebba Hellstrand, Sofie Nyström, Per Hammarström   +6 more
wiley   +1 more source

Beyond simplistic narratives: Dynamic farmers, precarity and the politics of agribusiness expansion

Journal of Agrarian Change, Volume 24, Issue 4, October 2024.
Abstract Agribusiness expansion is usually framed around two competing narratives. On the one hand, advocates present it as a promising vehicle to modernise agriculture and integrate small farmers into global value chains. On the other hand, critics denounce it as a top‐down corporate assault to monopolise agriculture and dispossess peasants of land ...
Enrique Castañón Ballivián
wiley   +1 more source

Mercosul

Meridiano 47, 2017
O presente artigo busca analisar a atual situação vivida pelo Mercosul, e suas principais dificuldades enfrentadas atualmente, especialmente em face à possibilidade de instauração da ALCA.
Marcos Costa Lima
doaj  

A América do Sul em movimento

Brazilian Journal of Political Economy, 2008
South America in movement. This paper discusses the prospects for the integration of South America, stressing that there are two competing projects.
Paulo Nogueira Batista Jr.
doaj   +1 more source

Amyloid beta 1‐40 and 1‐42 fibril ratios and maturation level cause conformational differences with minimal impact on autophagy and cytotoxicity

Journal of Neurochemistry, Volume 168, Issue 9, Page 3308-3322, September 2024.
The amyloid β (Aβ) peptide varies in length between 37 and 49 amino acids, with Aβ1‐42 being the most disease‐related and forms plaques in Alzheimer's disease. Aβ1‐40 also forms plaques and intertwines with Aβ1‐42, but their combined effect is still not clearly understood. Here, we fibrillized different Aβ1‐40:42 ratios and characterized both early and
Lovisa Johansson, Alexander Sandberg, Sofie Nyström, Per Hammarström, Martin Hallbeck   +4 more
wiley   +1 more source