Results 101 to 110 of about 45,723 (219)

Modeling and Simulation in Development and Regulatory Approval of Chimeric Antigen Receptor T‐Cell Therapies: An Analysis of European Medicines Agency Centralized Procedures From 2018 to 2024

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 4, April 2026.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapies represent a major advancement in oncology. These therapies have demonstrated therapeutic potential, particularly in hematological malignancies where patients have relapsed or are refractory to prior treatments.
Lisa Hanquet, Jean‐Michel Dogné, Flora T. Musuamba   +2 more
wiley   +1 more source

Antitumor effect of the Newcastle disease virus strain NDV/Altai/pigeon/777/2010 on a model of solid Lewis carcinoma

Юг России: экология, развитие
Aim. To evaluate the efficacy of intratumoral administrations of the Newcastle disease virus strain NDV/Altai/pigeon/777/2010, to compare progression of the tumor nodes after virotherapy and to analyse pathomorphological changes in the tumor tissue in ...
Yu. I. Karkavin, L. S. Adamenko, K. S. Yurchenko, A. V. Glushchenko   +3 more
doaj   +1 more source

Use of Modeling and Simulation to Inform the Development of Monoclonal Antibodies to Treat Moderate‐to‐Severe Asthma: A Retrospective Review of EMA Centralized Procedure From 2014 to 2024

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 4, April 2026.
ABSTRACT We present here a repository of key regulatory questions answered in centralized procedures and evaluate the place of modeling and simulation in marketing authorization process for biologics approved for the treatment of moderate‐to‐severe asthma from 2014 to 2024.
Hélène Haguet, Jean‐Michel Dogné, Flora T Musuamba   +2 more
wiley   +1 more source

Angiogenic potency evaluation of cell therapy candidates by a novel application of the in vitro aortic ring assay

Stem Cell Research & Therapy, 2017
Background Due to limitations of current angiogenesis assays, we aimed to develop a novel application of the rat aortic ring assay to assess the angiogenic potential of mesenchymal stromal cells (MSCs).
Farwah Iqbal, Peter Szaraz, Matthew Librach, Andrée Gauthier-Fisher, Clifford L. Librach   +4 more
doaj   +1 more source

Bottom‐up effects of female strategic leadership: Firm performance effects through employees

Strategic Management Journal, Volume 47, Issue 4, Page 947-973, April 2026.
Abstract Research Summary Scholars have found that female representation in strategic leadership is often positively associated with firm performance, though the underlying mechanisms remain unclear. Prior explanations emphasize top‐down effects, considering how female leaders shape strategic decision‐making or influence legitimacy.
Seung‐Hwan Jeong, Saehee Kang, Kris Byron   +2 more
wiley   +1 more source

Ferrocenium tetrachloromagnesate modified MWCNTs electrode for detection of bismuth(III) at the trace level in polluted aqueous solutions

Journal of Electrochemical Science and Engineering
This study presents the fabrication of a ferrocenium tetrachloromagnesate (FTM) modified multi-walled carbon nanotubes (MWCNTs) electrode for the voltammetric determination of bismuth ions (Bi3+) in aquatic environments. The FTM was synthesized from the
Rahadian Zainul, Alwi Nofriandi, Norhayati Hashim, Mohamad Idris Saidin, Mohamad Syahrizal Ahmad, Siti Nur Akmar Mohd Yazid, Sharifah Norain Mohd Sharif, Wan Rusmawati Wan Mahamod, Illyas Md Isa   +8 more
doaj   +1 more source

‘DIE WISSEN ALLE NOCH NICHT, WER DU BIST’: BODY NARRATIVE AND TRANS EMBODIMENT IN SABINE BERNARDI'S ROMEOS (2011)

German Life and Letters, Volume 79, Issue 2, Page 184-202, April 2026.
Abstract This article examines the narrative structure of Romeos (Sabine Bernardi, 2011) through the lens of body narrative. While traditional body narrative emphasises the felt discomfort of being trapped in the ‘wrong body’, Romeos challenges this essentialist framework by foregrounding Lukas's trans identification and trans masculinities through an ...
Mingyuan Wan
wiley   +1 more source

Quantifying Root Resorption on the Incisors After Clear Aligner and Fixed Appliance Therapy Using Artificial Intelligence Tool Based CBCT Surface Models: Randomized Clinical Trial

Orthodontics &Craniofacial Research, Volume 29, Issue 2, Page 366-374, April 2026.
ABSTRACT Objective To quantify external apical root resorption (EARR) on the incisors following non‐extraction treatment of Class I malocclusion patients with moderate crowding, comparing clear aligners and fixed appliances using a novel 3D analysis of Cone‐Beam Computed Tomography (CBCT) derived surface models.
Roberto Bespalez‐Neto, Claudia Trindade Mattos, Lucia Helena Soares Cevidanes, Thais Maria Freire Fernandes, Ana Cláudia de Castro Ferreira Conti, Renata Rodrigues de Almeida‐Pedrin, Paula Vanessa Pedron Oltramari   +6 more
wiley   +1 more source

Bridging the divide: Using metacognitive training to reduce hostility between the political left and right

Political Psychology, Volume 47, Issue 2, April 2026.
Abstract The study aimed at reducing the propensity for violence among supporters of left‐wing parties toward the right‐wing Alternative for Germany (AfD) as well as supporters of the AfD toward the German left‐wing Green Party (Die Grünen) using metacognitive training (MCT). A total of 1025 German participants were recruited online.
Steffen Moritz, Lisa Borgmann, Tanja M. Fritz, Anja S. Göritz, Klaus Michael Reininger   +4 more
wiley   +1 more source

Mixed‐Oxide Nanostructure‐Based Electrochemical Sensors for Environmental Pollutants

Analysis &Sensing, Volume 6, Issue 2, March 2026.
This review discusses the development of mixed‐oxide electrochemical sensors for detecting environmental pollutants, covering various work electrodes, combinations of nanomaterials for enhanced sensing, and real‐world diagnostic applications. Emerging environmental pollutants pose increasing risks to ecosystems and human health, creating a demand for ...
Cavour M. Neto, Camila C. Silva, Carlos W. Mendonça, Daniel Y. Tiba, João H. A. Ferreira, Laura C. Lieb, Octávio P. L. de Souza, Willian V. L. Belino, J. G. Manjunatha, Thiago C. Canevari   +9 more
wiley   +1 more source