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The development of type 2 diabetes amongst sibling pairs in the South‐South region of Nigeria: The effect of genetics, environment and lifestyle

Diabetic Medicine, Volume 43, Issue 6, June 2026.
Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye, Ibi Erekosima, Adrian H. Heald, Gesiye Bozimo, Simon G. Anderson, Samuel Seidu, Kariba Akhidue, Adaeze Ugwu, Chioma Unachukwu, Ibitrokoemi Korubo, Kingsley Chukwuemeka Patrick‐Iwuanyanwu, Victoria Gomba, Uwoma Batubo, Victoria Akanatei, Victor Ken‐Uba, Iyeopu Siminialayi, Sokiprim Akoko, Justin Ideozu, Hamilton Opurum   +18 more
wiley   +1 more source

Temperature-Dependent Atomic Layer Deposition of Passivating ZnO Nanolayers for Dye-Sensitized Solar Cells. [PDF]

Nanomaterials (Basel)
Addae EA, Szindler M, Sitek W, Matus K.
europepmc   +1 more source

FTO-Mediated Mitigation of Ferroptosis Occurs in an ACSL4-Dependent Manner in Diabetic Cardiomyopathy. [PDF]

Cardiovasc Toxicol
Chen XX, Gu Y, Yin Z, Li YT, Ma ZC, Wang W, Hou YQ, Wang X.   +7 more
europepmc   +1 more source

N⁶-Methyladenosine (m⁶A)-Mediated Regulation of Lipid Metabolism: Molecular Mechanisms, Pathological Implications, and Therapeutic Perspectives. [PDF]

Biomolecules
Zhu Q, Hu Y, Li M, Yang H, Zhao L, Zhao Y.   +5 more
europepmc   +1 more source

Emerging roles of RNA m⁶A modification in multiple myeloma pathogenesis and treatment resistance (Review). [PDF]

Int J Oncol
Maimaitiyiming Y, Hu S, Bai D, Guan Y, Bu N, Hao W, Maimaiti M.   +6 more
europepmc   +1 more source

Targeting the m⁶A RNA demethylase FTO enhances UVB-induced DNA damage repair and suppresses skin tumor growth. [PDF]

Photochem Photobiol
Yang Z, Verghese M, Cui YH, Wei J, Yang S, He C, He YY.   +6 more
europepmc   +1 more source

FTO-mediated m6A modification regulates the osteogenic differentiation of ADSCs by targeting FOXO1. [PDF]

Stem Cell Res Ther
Wang Z, Wen S, Li H, Wang X, Guo S, Yang S.   +5 more
europepmc   +1 more source

Association of FTO rs9939609 with Obesity.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2018
Sora, Yasri, Viroj, Wiwanitkit
openaire   +1 more source

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FTO – Friend or Foe?

Hormone and Metabolic Research, 2009
Fat mass and obesity associated gene ( FTO) is the most relevant polygene for obesity to date. It has been identified by genome wide association studies concerning body weight regulation. However, its functional relevance for the pathogenesis of obesity remains elusive.
D, Tews, P, Fischer-Posovszky, M, Wabitsch   +2 more
openaire   +2 more sources