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<i>Mycobacterium</i> Transcriptional Factor BlaI Regulates Cell Division and Growth and Potentiates β-Lactam Antibiotic Efficacy Against <i>Mycobacteria</i>. [PDF]

Microorganisms
Xu J, Zhang M, Xie F, Zhen J, Abuliken Y, Gao C, Dai Y, Jiang Z, Li P, Xie J.   +9 more
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Ampicillin susceptibility testing of Haemophilus influenzae in the routine clinical laboratory by the EUCAST methodology compared to broth microdilution and the presence of ftsI gene mutations

Clinical Microbiology and Infection
To investigate the prevalence of ampicillin resistance in Haemophilus influenzae and the diagnostic accuracy of the EUCAST recommended disc diffusion method to detect the increasingly prevalent ampicillin resistance due to the presence of PBP3 alterations based on mutations in the ftsI gene.During a 6-month period all consecutive non-duplicate H ...
Adri G M Van Der Zanden
exaly   +3 more sources

Direct detection by real-time PCR of ftsI gene mutations affecting MICs of β-lactam agents for Haemophilus influenzae isolates from meningitis

Journal of Infection and Chemotherapy, 2011
One resistance mechanism of Haemophilus influenzae to ampicillin involves decreased affinity of penicillin-binding protein (PBP) 3 for β-lactam antibiotics reflecting amino acid substitutions in PBP3 encoded by the ftsI gene. Three amino acid substitutions, Ser385Thr, Arg517His, and Asn526Lys, are especially responsible for β-lactam resistance.
Miyuki Morozumi, Naoko Chiba
exaly   +3 more sources

A Far Upstream Region is Required for Expression of the ftsI Gene Coding for Penicillin-Binding Protein 3 of Escherichia coli

1993
The ftsI (pbpB) gene of Escherichia coli codes for penicillin-binding protein 3 (PBP 3), a cytoplasmic membrane protein that functions as DD-transpeptidase for the formation of a septum of the murein sacculus and is the principal lethal target of β-lactam antibiotics.
Hiroshi Hara
exaly   +2 more sources

Genetic Diversity of the ftsI Gene in β-Lactamase-Nonproducing Ampicillin-Resistant and β-Lactamase-Producing Amoxicillin-/Clavulanic Acid-Resistant Nasopharyngeal Haemophilus influenzae Strains Isolated from Children in South Korea [PDF]

Microbial Drug Resistance, 2013
Haemophilus influenzae frequently colonizes the nasopharynx of children and adults, which can lead to a variety of infections. We investigated H. influenzae carriage in the nasopharynx of 360 children, in terms of (1) the prevalence of strains with decreased susceptibility,
Chulmin Park, Kyung-Hyo Kim, Na-Young Shin, Ji-Hyun Byun, Eun-Young Kwon, Jae-Wook Lee, Hyo Jin Kwon, Eu Yoon Choi, Dong-Gun Lee, Woo Yun Sohn, Jin Han Kang   +10 more
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Influence of Haemophilus influenzae β-lactamase production and/or ftsI gene mutations on in vitro activity of and susceptibility rates to aminopenicillins and second- and third-generation cephalosporins

International Journal of Antimicrobial Agents, 2007
P Coronel, M J Giménez, Lorenzo Aguilar   +2 more
exaly   +3 more sources

Isolation of ftsI and murE genes involved in peptidoglycan synthesis from Corynebacterium glutamicum

Applied Microbiology and Biotechnology, 2001
Corynebacterium glutamicum is known to excrete large amounts of L-glutamic acid upon treatment by penicillin. However, the mechanism of L-glutamate overproduction by penicillin treatment is still unknown. A 5.3-kb HindIII fragment was isolated by directly introducing the C.
Wijayarathna, C. D., Wachi, M., Nagai, K.   +2 more
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Diverse mutations in the ftsI gene in ampicillin-resistant Haemophilus influenzae isolates from pediatric patients with acute otitis media

Journal of Infection and Chemotherapy, 2010
To clarify molecular changes in beta-lactamase-nonproducing, ampicillin-resistant (BLNAR) Haemophilus influenzae, which is increasing in pediatric patients with acute otitis media (AOM) in Japan, we identified amino acid (aa) substitutions in penicillin-binding protein 3 for the BLNAR strains. Of 191 H. influenzae strains isolated from middle ear fluid
Kozue, Kishii, Naoko, Chiba, Miyuki, Morozumi, Keiko, Hamano-Hasegawa, Iku, Kurokawa, Junko, Masaki, Kimiko, Ubukata   +6 more
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